Images in Rheumatology

Central Nervous System Vasculopathy in Systemic Sclerosis Resolved by Vasodilator Therapy

📖 doi.org/10.3899/jrhe...

#SystemicSclerosis

🧬 Excited to share our new preprint!

We characterized CD4+ T cells in #SystemicSclerosis using #SingleCellRNAseq, revealing IFN-driven activation, Treg dysregulation, and Th2/Th17 expansion in disease.

📄 www.biorxiv.org/content/10.6...

#scRNAseq #Immunology #SSc

A new study published in Nature Medicine shows that CD19×CD3 and BCMA×CD3 T cell engagers improve disease outcomes in patients with treatment-refractory #AntisynthetaseSyndrome and #SystemicSclerosis.

👉 Read the paper: https://go.nature.com/4cxHN92
👉 Listen to the discussion: https://bit.ly/3OVwMo6

New Study to Evaluate Tibulizumab in Systemic Sclerosis A randomized, double-blind, placebo-controlled study will assess the efficacy, safety, and tolerability of tibulizumab in adults with diffuse cutaneous SSc.

#SSWC2026: A randomized, double-blind, placebo-controlled study (TibuSURE, #NCT06843239) is looking to assess the efficacy, safety, and tolerability of #Tibulizumab in adults with diffuse cutaneous #SystemicSclerosis (SSc).

Learn more: https://bit.ly/4loDQFR

#RareDisease #SSc #TibuSURE

PHQ-8 Performs Comparably for People With Diffuse and Limited SSc An analysis of the Patient Health Questionnaire did not demonstrate substantial differences in SSc across factors such as sex, age, and language.

Findings from an analysis of the Patient Health Questionnaire did not demonstrate substantial differences in patients with #SystemicSclerosis (SSc) across factors such as sex, age, and language of administration. @acr-journals.bsky.social

Read more: https://bit.ly/4080DMA

#RareDisease #SSc

Quell takes new Treg into clinic after transplant study halt Quell Therapeutics changes tack, starting trials of a CAR-Treg in rheumatoid arthritis and systemic sclerosis and sidelining its transplant therapy.

UK biotech #QuellTherapeutics has started #humantrials of #autologousCARTreg therapy QEL-005 in #rheumatoidarthritis and #systemicsclerosis, after pressing pause on its former lead programme for organ transplant rejection.

Attending the World Congress on #SystemicSclerosis in Athens next week?

Anna Clark, Editor-in-Chief, invites you to reach out with enquiries.

Explore our scope, reach & impact, commitment to publishing excellence, & more: hubs.li/Q03BLchR0

A&R Research Review Possible Novel Biomarkers for Systemic Sclerosis Read the latest research summary from The Rheumatologist

Research published in Arthritis & Rheumatology highlights possible novel biomarkers and therapeutic targets for #SystemicSclerosis

The Rheumatologist summarizes the findings: https://ow.ly/mPia50YcTqZ

ACR Journals

Study Finds Patients With SSc at Increased Risk of Interstitial Lung Disease Recent research suggests that it is important for clinicians to identify the risk of ILD in patients with SSc so that relevant therapies can be initiated.

Because patients with #SystemicSclerosis (#SSc) are at risk of new-onset #InterstitialLungDisease (#ILD), screening should be regularly conducted. Study in @ard.eular.org

Read more: https://bit.ly/3Z7fzK

#RareDisease #MedSky

Research Article

Long-Term Epidemiology of Systemic Sclerosis in Western Australia: A Population-Level Linked Data Study

📖 www.jrheum.org/cgi/content/...

#Epidemiology #SystemicSclerosis

Fatigue a Prevalent Problem in SSc and Other Inflammatory Rheumatic Diseases Recent research found that fatigue continues to be a prevalent issue in systemic sclerosis and other inflammatory rheumatic and musculoskeletal diseases.

#Fatigue is a prevalent symptom across inflammatory rheumatic disease, including #SystemicSclerosis (SSc), according to a study published in Seminars in Arthritis and Rheumatism.

Read more: https://bit.ly/4poKKeJ

#RareDisease #SSc #Rheumatology

🧪📘 Welcoming 2026 with new research.

The January issue of @jrheumatol.bsky.social (Vol. 53, Issue 1) is now available.

📖 www.jrheum.org/content/53/1...

#RheumatoidArthritis #Spondyloarthritis #Lupus #SjögrenDisease #SystemicSclerosis #Vasculitis #Myositis

The Presence of Abnormal Septal Motion on Echocardiography Is a Predictor of Abnormal Cardiac Magnetic Resonance in Systemic Sclerosis Heart risks in SSc? Study finds 50%+ have CMR-detected myocardial fibrosis; ASM on ECHO predicts it—early screening tool. #SystemicSclerosis #CardiacHealth

Heart risks in SSc? Study finds 50%+ have CMR-detected myocardial fibrosis; ASM on ECHO predicts it—early screening tool. #SystemicSclerosis #CardiacHealth
www.rimpacts.com/rd/p?c=10045... 📄DOI: doi.org/10.1093/rheu...

Botulinum Toxin for Refractory Digital Ischemia and Ulcers in Systemic Sclerosis This systematic review and meta-analysis examine the effectiveness and safety of botulinum toxin injections for ischemic digital complications.

Inyecciones con toxina botulínica son un adjunto seguro y efectivo para la isquemia digital refractaria en pacientes con esclerosis sistémica #botox #systemicsclerosis jamanetwork.com/journals/jam...

Our Jan 2026 issue is live!

Including #RheumatoidArthritis, #IgG4-related disease, and #SystemicSclerosis, plus much more! thelancet.com/journals/lan...
#Medsky #Rheumsky

And introducing our cover artist for 2026, Emma Cheng @emma-cheng.bsky.social

Our December issue is live!

Including #ILD in #RA, #Sjögrens disease, and #SystemicSclerosis, plus much more! thelancet.com/journals/lan...
Cover by Sara Gironi Carnevale #Medsky #Rheumsky

NEWS You Might Have Missed
@multiple_sclerosis_support
@systemicsclerosis
@systemicsclerosis_thru_my_eyes
@thetruthofmultiple_sclerosis
#usa #healthcare #systemicsclerosis #mmj #mmjpatient #education #community #health #well #patient #patientcare #global #care

#ACR25: Jessica Bloom, MD, who is assembling a pediatric rheumatology registry, speaking Oct. 26 at the 2025 ACR Convergence in Chicago.

Image and quote taken by Senior Correspondent, Larry Luxner

#RareDisease #Rheumatology #SystemicSclerosis #RheumSky #MedSky

🎙️ September 2025 Editor's Summary Podcast

🎧 Listen here: jrheum.org/audiorheum

#spondyloarthritis #lupus #vasculitis #systemicsclerosis #pediatric #osteoarthritis #rheumatology

Research Article

Outcomes in Systemic Sclerosis–Associated Interstitial Lung Disease Based on Serological Profiles With a Focus on Anticentromere and Anti-RNA Polymerase III Antibodies

📖 doi.org/10.3899/jrhe...
@uofcalifornia.bsky.social @cuimcmedicinedept.bsky.social

#systemicsclerosis

Editorial

Personalizing Management of Systemic Sclerosis–Associated Interstitial Lung Disease: Are Autoantibodies the Key for Risk Stratification?

📖 doi.org/10.3899/jrhe...

#interstitiallungdisease #systemicsclerosis

Welcome, September!

Read our latest issue here 🗞️: www.jrheum.org/content/52/9...

#sjögrendisease #rheumatoidarthritis #spondyloarthritis #lupus #vasculitis #systemicsclerosis #pediatric #osteoarthritis #rheumatology

Scientists Identify Immune Cells That Unlock Scleroderma Mysteries – Asian Scientist Magazine

...elevated levels of specific immune cells in systemic sclerosis patients and the development of conditions like scleroderma renal crisis and interstitial lung disease.

#kidneys #lungs #scleroderma #autoimmunediseases #SystemicSclerosis

www.asianscientist.com/2025/08/heal...

A study co-authored by Carrie Richardson, MD, reviewed the Genetics vs Environment in Scleroderma Outcomes Study and the Collaborative National Quality and Efficacy Registry cohort data to understand why #Raynaud's phenomenon is often the first sign of #SystemicSclerosis

t.co/NALcn6LUJH

🎙️ July 2025 Editor's Summary Podcast

🎧 jrheum.org/audiorheum

#rheumatoidarthritis #stilldisease #spondyloarthritis #psoriaticarthritis #systemicsclerosis #vasculitis #rheumatology

Universal stem cells reset immunity in a systemic sclerosis patient Research led by Naval Medical University's Changzheng Hospital in China reports that an off-the-shelf cell therapy built from induced pluripotent stem cells (iPSCs) loosened life-limiting skin and org...

medicalxpress.com/news/2025-07... #SystemicSclerosis #Health

Research Article

Characteristics of Overlap Syndrome in a Large Cohort of Brazilian Patients With Systemic Sclerosis: A Retrospective Analysis

📖 www.jrheum.org/cgi/content/...

#overlapsyndrome #prognosis #systemicsclerosis

Our July issue is now available!

Explore this month's articles:
📖 www.jrheum.org/content/52/7...

#rheumatoidarthritis #stilldisease #spondyloarthritis #psoriaticarthritis #systemicsclerosis #vasculitis #rheumatology

Our student rounded out the morning session:
🔬 Ifeoluwa Emmanuel Bamigbola on using #Multiomics to map #SystemicSclerosis
🧫 Callum Rimmer on the evolution of #StaphylococcusEpidermidis over six years
🧪 Ollie Megram on making #metabolomics more accessible via benchtop #NMR
#SHIMR_NTU

The TFIID complex is a new autoantibody target in systemic sclerosis Systemic sclerosis (SSc) is characterised by systemic fibrosis, vascular dysfunction, and the presence of antinuclear autoantibodies. The major SSc-associated antinuclear antibodies include anticentro...

The TFIID complex is a new autoantibody target in #systemicsclerosis.

Read about it in ARD ⬇️
ard.eular.org/article/S000...