🚨UBC TI Therapeutics Letter 161

Appropriate hemoglobin A1c testing frequency to monitor patients with #T2DM

www.ti.ubc.ca/2026/03/31/1...

"For patients with stable type 2 diabetes meeting glycemic goals, monitoring HbA1c every 6 months is as effective as every 3 months" #MedEd

🆕 UBC TI Therapeutics Letter 161 🆕

Appropriate hemoglobin A1c testing frequency to monitor patients with #T2DM

www.ti.ubc.ca/2026/03/31/1...

"For patients with stable type 2 diabetes meeting glycemic goals, monitoring HbA1c every 6 months is as effective as every 3 months" #MedEd

UBC TI #BestEvidence Webinar

1/ Appropriate HbA1c testing frequency to monitor patients with #T2DM

✅ Practical tips on optimal frequency of A1c testing
✅ Using TI #PrescribingPortaits to optimize your ordering of these tests

REGISTER t.co/ZGq1BfCXVm

#MedEd #diabetes

Immune checkpoint inhibitors → autoimmune diabetes risk, especially with pre-existing T2DM. Rapid C-peptide loss makes management tough. 🎨 Sketchnotes from Dr. Huda Al-Bahadili, MD's WashU lecture #ICI #Endocrinology #DiabetesAwareness #Oncology #T2DM

🧬 Gut–Barrier–Metabolism Axis: Transforming Metabolic Health!

Microbiome-targeted therapies (pro-, pre-, syn-, and pos) help restore gut balance, strengthen the barrier, reduce inflammation, and improve insulin function—key for #T2DM management.

🔗 microbiomecongress.org/registrations/

🧵 UBC TI #BestEvidence Webinar

1/ Appropriate HbA1c testing frequency to monitor patients with #T2DM

⏰ Weds 8 April @ Noon PDT
Speaker: The TI's Dr. Wade Thompson

✅ Practical tips on optimal frequency of A1c testing

REGISTER: www.ti.ubc.ca/2026/03/24/a...

#MedEd #LabTests #diabetes #HbA1c

Estimating prevalence and predictors of glucose-lowering overtreatment among older adults with type 2 diabetes in long-term care and community settings: a machine learning–based cohort study Objective To estimate the prevalence of potential overtreatment of type 2 diabetes mellitus (T2DM) among older adults and to develop and compare predictive models to identify patient and physician cha...

🆕 UBC TI publication:

Nearly 30% of older adults with type 2 #diabetes in BC may be over-treated, despite already having A1C ≤7% 😮 ⚠️
bmjopen.bmj.com/content/16/3...

#OverTreatment #T2DM #LTC #prescribing

RCT data showing that canagliflozin reduces myocardial fibrosis in high-risk #T2DM, providing imaging evidence for its cardioprotection #DiabetesResearch #SGLT2i

Canagliflozin attenuates CMR-quantified myocardial fibrosis in individuals with type 2 diabetes mellitus at high cardiovascular risk: a randomised open-label controlled trial - Diabetologia Aims/hypothesis We aimed to investigate canagliflozin’s effects on myocardial fibrosis, cardiac structure and function, and microcirculation in high-cardiovascular-risk type 2 diabetes mellitus throug...

Novel RCT: Canagliflozin reduces myocardial fibrosis (by CMR) in high-risk #T2DM, providing imaging evidence for its cardioprotection. A mechanism beyond glycaemic management. #SGLT2i #CardioDiabetes #HeartFailure #DiabetesResearch link.springer.com/article/10.1... 🔓

Pharmacovigilance analysis of the association between SGLT-2 inhibitors and diabetic foot infections using the FAERS database: An observational study Sodium-glucose cotransporter-2 (SGLT-2) inhibitors are widely used for the management of type 2 diabetes mellitus (T2DM) and heart failure (HF). SGLT-…

#health #publichealth #agedcare #diabetes #NCDs #geriatrics #primaryhealthcare #healthliteracy #aging #T2D #T2DM #healthinformatics

Canagliflozin shows a
163-fold higher diabetic foot infection signal
in adverse events data
than other SGLT-2 inhibitors.
.
www.sciencedirect.com/science/arti...

Biomarker Liver Fibrosis

Indian #T2DM + #MASLD cohort n=789

FIB-4 & NAFLD Fibrosis Score performed poorly (sensitivity ~22%) vs FibroScan/Vibration-controlled transient elastography for advanced fibrosis (LSM≥9.7 kPa)

#DiabetesMetabSyndr 2026
www.sciencedirect.com/science/arti...

Orforglipron offers greater weight loss for people with diabetes than oral semaglutide Novel weight-loss pill orforglipron (Emgality; Eli Lilly) offers patients with type 2 diabetes mellitus (T2DM) better blood sugar control and more weight loss than semaglutide — the only other GLP-1…

Patients with #type2diabetes taking weight-loss pill #orforglipron achieved better blood sugar control and more weight loss than those on #semaglutide in pill form, research shows

#weightloss #Emgality #EliLilly #diabetesmellitus #T2DM

buff.ly/vRMS2ir

Congrats to Yolanda, Ayush and Isha Jain’s lab. Really cool work that may revolutionize a variety of disease processes including #T2DM and possibly cancer.

Co-existing T2DM and MASLD: A cardiovascular high-risk phenotype. | Predictive Health Intelligence In Practice with Dr Denver: Co-existing T2DM and MASLD: A cardiovascular high-risk phenotype. Public health systems are facing a tsunami of metabolic disease, and the downstream impact is stark. Car...

Co-existing #T2DM + #MASLD is a cardiovascular high-risk phenotype, and often missed until too late.

~2x higher #MACE risk vs T2DM alone, even beyond traditional risk factors.

Katie Denver breaks down why and what it means for earlier identification.

Read: www.linkedin.com/posts/predic...

Working on my health. In 3 months my A1C went from 7.6 down to 6.5. Trying to be here for my grandsons graduation! Walking every day 😁
#a1c #diabetes #T2DM #T2D #walking

3🧵Prof William S Yancy has spent years researching how elevated #carbohydrate intake drives #metabolic risk, setting the stage for #T2DM, #obesity, #reflux & #cardiovascular disease.

Risk accumulates across systems 🧨🔥not in isolation.

#ReclaimingHealth #NewZealand

Environmental Endocrine‐Disrupting Chemicals, Pancreatic β‐Cells, and Type 2 Diabetes Mellitus Objective To clarify the link between environmental pollution and diabetes risk by focusing on pancreatic β-cells as key targets of environmental insults, with emphasis on the role of endocrine-disr...

#ecology #health #gerontology #SDGs #endocrinology #diabetes #nephrology #CKD #publichealth #histology #healthequity #NCDs #healthliteracy #T2D #T2DM #ecotoxicology #ESRD

Environmental pollutants
play a significant role in

β-cell dysfunction
and diabetes.
.
onlinelibrary.wiley.com/doi/full/10....

Mitonuclear Discordance and Gout, Type 2 Diabetes and Chronic Kidney Disease in Aotearoa New Zealand Indigenous Māori and Pacific People Background Mitochondrial proteins are encoded by both mitochondrial- and nuclear-encoded genes. Because mitochondrial DNA (mtDNA) is maternally inherited, admixed individuals may have different ance...

An Early View: Mitonuclear discordance has been proposed to impair #mitochondrial function in admixed populations.

In 2,301 Māori and Pacific peoples in Aotearoa New Zealand, higher discordance was associated with lower risk of #gout and #T2DM, particularly in the prevalent B4a1a mtDNA haplogroup.

GLP-1 Receptor Agonists and Risk of Optic Nerve or Vision-Threatening Events in Patients With Type 2 Diabetes or Cardiometabolic Diseases: A Meta-analysis of Randomized Controlled Trials BACKGROUND. Data concerning glucagon-like peptide 1 receptor agonists (GLP-1 RAs) on risk of ischemic optic neuropathy (ION) are conflicting.PURPOSE. We sy

In pts w #T2DM & cardiometabolic dz, GLP-1 RAs were not associated w increased risk of optic nerve/vision-threatening events #MedSky #GLP1 #OphthoSky
diabetesjournals.org/care/article-abstract/doi/10.2337/dc25-1929/164303/GLP-1-Receptor-Agonists-and-Risk-of-Optic-Nerve-or

In silico computational screening and molecular dynamics analysis unveil Moringa oleifera phytochemicals as a promising PPAR-γ receptor agonist for targeted diabetes management strategies

Screening 42 #Phytochemicals from #MoringaOleifera identified #Epicatechin and #Genistein as potent PPAR γ modulators with superior binding affinity to #Rosiglitazone, underscoring their promise as natural #Antidiabetic agents for #T2DM therapy.
Open Chemistry: doi.org/10.1515/chem...

Protective effects of methanolic broccoli (Brassica oleracea var. italica) extract on metabolic dysfunction and hypothalamo-hypophyseal axis oxidative stress in a rat model of diet-induced type 2 diabetes mellitus

Scientists show #MethanolicExtract of #BrassicaOleracea florets protects #cafeteria diet induced #T2DM rats by normalizing #glycemia, restoring lipid profiles, reducing #OxidativeStress, and safeguarding hypothalamo hypophyseal tissues.

Open Chemistry: doi.org/10.1515/chem...

Longitudinal associations of long-term exposure to ambient air pollution, residential greenness, and air temperature with type 2 diabetes subphenotypes: Results from the KORA cohort study To examine the association between environmental exposures and specific type 2 diabetes (T2D) subphenotypes.We categorized T2D participants from the K…

#endocrinology #diabetes #health #publichealth #T2D #T2DM #ecotoxicology #exposome #healthinformatics #environment

Association between
air pollution
and insulin resistance
.
www.sciencedirect.com/science/arti...

#health #agedcare #menopause #ecology #SDGs #gerontology #exposome #healthinformatics #publichealth #primaryhealthcare #T2D #T2DM #Alzheimers #ecotoxicology #NCDs

Robust dose-dependent positive association between

blood levels of cadmium (Cd)

and diabetes.
.
www.besjournal.com/fileSWYXYHJK...

What is the association between preoperative #GLP-1 receptor agonist use and periop #respiratory complications in #T2DM patients?

Read the full article here: www.bjanaesthesia.org.uk/article/S0007-0912(25)00...

❓Is #Anxiety hiding early #Dementia cases?🤯Misdiagnosis delays help!⏳ #T2DM = longer diagnosis time! @mdpiopenaccess.bsky.social #MentalHealthMatters #NeuroScience #EarlyDiagnosis
🧪 Dive deeper 📚
www.mdpi.com/2227-9059/13...

Born #OTD, Carl Cori was one of the first #LaskerAward winners. He was recognized for contributions to the knowledge of carbohydrate metabolism, which clarified the action of insulin in diabetes. #T2DM ow.ly/lMOa50CtPiw 🧪

❓Ever wondered why young minds fade too soon? 😨 Symptoms before 65 get mislabeled 🧩 Key risks: #T2DM & #TBI 🚨 @mdpiopenaccess.bsky.social #DementiaAwareness #YoungOnsetDementia #BrainHealth
Read + share 👉
www.mdpi.com/2227-9059/13...

TI Annual Course
ti.ubc.ca/annual-cours...

Speaking now: Dr. Guillaume Grenet

"Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors in type 2 diabetes"

👎 LOW evidence for primary CVD prevention

#DrugEvidence25 #CME #MedEd #T2DM #diabetes #GLP1

TI Annual Course
ti.ubc.ca/annual-cours...

Speaking now: Dr. Guillaume Grenet

"Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors in type 2 diabetes"

👎 LOW evidence for primary CVD prevention

#DrugEvidence25 #CME #MedEd #T2DM #diabetes #GLP1

TI Annual Course
ti.ubc.ca/annual-cours...

Speaking now: Dr. Guillaume Grenet

"Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors in type 2 diabetes"

#DrugEvidence25 #CME #MedEd #T2DM #diabetes #GLP1