New study in Nature shows #ImmuneAgeing starts early with T cell reprogramming and GATA3 activity. Adding antibody reactome profiling to these cohorts can reveal the extrinsic viral and environmental triggers of #Aging —a vital layer for the #MultiOmics stack.
rdcu.be/fcrJT
#HumanHealth
A new #HumanImmuneHealthAtlas published in Nature reveals that #ImmuneAgeing is a non-linear process starting earlier than we thought. By mapping these molecular transitions, we can better tailor vaccines and therapies to biological age, not just the clock.
rdcu.be/fcrJT
#Immunology #SystemsBiology
A new @cellcellpress.bsky.social study of 2,279 brain samples reveals deep molecular diversity in #Neurodegeneration. By mapping #Proteomics & PTMs, we move closer to #PrecisionMedicine and improved stratification between seemingly similar neurodegenerative diseases.
www.cell.com/cell/fulltex...
New research in @natmed.nature.com reveals IgG1 producing #Bcells are key to cancer #immunotherapy success. Data from 2k+ patients show these cells coordinate with T-cells to drive anti-tumor immunity. A shift toward humoral-cellular strategies could transform outcomes.
rdcu.be/e90xd
New study from #LifelinesNEXT cohort: a map of 31k+ gut viruses in mother-infant pairs. Key findings: vaginal birth & breastfeeding drive viral diversity, linked to future allergy risk. Large-scale longitudinal measurements generate unique findings for human health.
doi.org/10.64898/202...
Thrilled to welcome Brian McKelligon as the new CEO of Infinity Bio! Brian's leadership will accelerate the reach of our #MIPSA technology and the inSIGHTs it delivers to researchers worldwide. Welcome to the team, Brian!
#InfinityBio #AntibodyReactomics
www.businesswire.com/news/home/20...
#MultipleSclerosis progression insights via #proteomic profiling: New study on MS reveals anti-viral response as a continuous disease driver, implicating #EBV infection beyond just a trigger. Highlights include sex-specific pathways for injury, repair & resilience.
rdcu.be/e7ZWe
#MSResearch
Infinity Bio's Katy Shaw-Saliba & Ben Larman just published a new study screening 85 Ig batches against 283,000+ viral peptides, uncovering pandemic-driven immune shifts & autoantibody changes. Discoveries like this begin with decoding the antibody reactome. doi.org/10.1002/eji....
Researchers identified proteomic markers for #LymphoidCancer risk up to 10yrs before diagnosis. This large-scale discovery reveals how early molecular signatures like sCD23 can drive risk stratification & #EarlyDetection
rdcu.be/e6GBZ%E2%80%8B
#Proteomics #PrecisionMedicine #Biomarkers #Lymphoma
New research in #SjogrensDisease uses salivary & serum #Proteomics to link biomarkers with #HLA alleles and autoantibodies. Large-scale, multi-omic analysis like this reveals a dynamic immune record, paving the way for high-resolution patient stratification.
doi.org/10.1016/j.ar...
Groundbreaking study in @natmetabolism.nature.com uses #MultiOmics to reveal #genes & #proteins causal to #T2D. With 85% of effects tissue-specific, large-scale profiling across ancestries is key to unlocking #global therapeutic targets.
rdcu.be/e4zRC
#PrecisionMedicine #TranslationalResearch
New Cohort of the Week from @nataging.nature.com!
By analyzing nearly 1,000 human CSF samples, researchers mapped thousands of protein changes linked to #BrainAging and AD. #Proteomics on large human cohorts set the foundation for CNS markers of an aging brain.
pmc.ncbi.nlm.nih.gov/articles/PMC...
A new study in @natcomms.nature.com re-analyzed WGS data from ~750k individuals to find viral "dark matter". By mapping viral reads, researchers linked persistent #EBV to #chronicdiseases like Lupus and Dementia. Large-scale omics are key to unlocking new disease #biomarkers
Article: rdcu.be/e2cAt
New study in @natcomms.nature.com: A 29-protein blood signature predicts #cancer in patients with vague symptoms. Crucially, it distinguishes malignancy from #autoimmune & infectious diseases. A vital triage tool to prioritize life-saving diagnostics. #PrecisionMedicine
Read: rdcu.be/eZ6bE
A new study leverages a well characterized infant cohort to explore our #microbiome & immune health.
Researchers analyzed 647 infants in the #COPSAC cohort & found environmental exposure (daycare, siblings) reduced anellovirus abundance, consistent with immune "training."
#Virome #ImmuneSystem
New Nature Medicine research maps blood #biomarkers related to #aging.
By analyzing 54 biomarkers related to accumulated disease over 15 years, researchers identified key "biological signatures" predictive of aging. Large cohort studies are transformative for predictive health! #geroscience
New research reveals a link between Epstein-Barr virus (EBV) & Primary Sclerosing Cholangitis. Systematic #immuneprofiling shows that #PSC associated T & B cells target #EBV, suggesting it may drive pathogenesis.
www.nature.com/articles/s41...
#Omics #LiverDisease #Autoimmunity #Bcell #Tcell
Great news in neurodegeneration research! Hok-A-Hin et al. used large-scale CSF proteomics on a multicenter cohort to identify new biomarkers for Frontotemporal Dementia (FTD). Importantly, identified biomarker panels distinguish FTD from Alzheimer’s in presymptomatic cases.
lnkd.in/eatVVT6K
New research sheds light on the food allergy. Gill, et al. found that children with food sensitization have gE B-cells that are less mature, more diverse. This was abrogated (stopped) by having a pet dog in the first year of life, supporting the hygiene hypothesis. doi.org/10.1111/all....
Cohort of the Week: Exciting new study on a large cohort of Guillain-Barré syndrome patients. Glycolipid complex auto-antibody patterns cluster into groups linked to clinical features. A step towards personalized medicine for the diagnosis, prognosis, & treatment of GBS. doi.org/10.1093/brai...
Lupus (SLE) symptoms are notoriously varied. New research groups patients into 6 'serological subsets' based on autoantibody profiles. Links to genetic factors (NCF2, HLA) help predict specific outcomes, like blood disorders or lower rates of kidney disease.
www.translationalres.com/article/S193...
Diagnosing TB in children is a persistent challenge, as sputum-based tests are often ineffective. A new study used advanced plasma proteomics to identify a non-sputum-based biosignature for TB. The identified signatures meet WHO accuracy guidelines for a pediatric TB diagnostic.
Read: rdcu.be/eOtzp
Diagnosing Lyme disease in the nervous system is slow & often requires an invasive spinal tap. A new study in Nature Communications used proteomics & machine learning to identify a diagnostic protein signature in plasma, crucial progress toward a less invasive test.
www.nature.com/articles/s41...
Infinity Bio, Inc. is excited to join the LoCITT trial, powering advanced antibody reactome profiling to uncover key immune signatures & improve long COVID treatment. Proud to partner with Scripps Research for remote scientific progress.
#LongCovid #LoCITT #AntibodyProfiling #Immunology
A study by Ruberto et al. profiled immune responses to HERV-W retrovirus proteins in Multiple Sclerosis patients. The findings suggest pHERV-W could be a valuable biomarker for predicting MS disease progression.
www.frontiersin.org/journals/imm...
#MultipleSclerosis #Immunology #InfectiousDisease
A groundbreaking study in Science creates a pan-disease blood atlas using proteomic 'fingerprints.' Analyzing 8262 individuals, they identified signatures for 59 diseases, found common biological themes, & developed a model that predicted lung cancer years before diagnosis.
#Proteomics #Biomarkers
For our "Cohort of the Week," we are celebrating a study by Parodis and colleagues that tackles the challenge of diagnosing Systemic Lupus Erythematosus (SLE).
Read the full paper: ard.eular.org/article/S000...
#Lupus #SLE #Autoimmune #Biomarkers #Diagnostics
Immune responses to common viruses may lower dementia risk. Older adults with higher antibodies to HCoV-OC43 showed better cognition and brain health, with IGDCC4 identified as a promising target for neurodegeneration prevention.
www.science.org/doi/10.1126/...
#Neuroscience #Alzheimers #Immunology
his week, we are inspired by groundbreaking research from the IMPACC study, published in JCI. In their paper, “A multi-omics recovery factor predicts long COVID in the IMPACC study,”
Read here: www.jci.org/articles/vie...
#LongCOVID #LC #MultiOmics #Biomarkers #PrecisionMedicine #IMPACC
Our "Cohort of the Week" is a study on Lupus Nephritis (LN). Researchers used immunophenotyping to find distinct immune signatures in patients that traditional methods missed, linking them to treatment outcomes. A major step toward personalized medicine for LN. Read here: www.jci.org/articles/vie...