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Posts by Rebsamen Lab @UNIL

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Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…

We're thrilled to share the lab's latest publication demonstrating how caspase-4 and the non canonical inflammasome recognize cytosolic LPS by preferentially binding to the convex portions of membranes - both bacterial and micelles @cp-immunity.bsky.social
www.sciencedirect.com/science/arti...

2 months ago 23 11 1 1

Join us!
Still few days to apply to the open PhD position in our lab @dib-unil.bsky.social Lausanne🇨🇭!
Deadline: 20.12.2025
More info👇 and www.rebsamenlab.org

4 months ago 4 2 0 1
Career Opportunities: Graduate assistant (PhD student) position Rebsamen Lab: Innate immunity and autoimmunity (22580)

🚨 Join our lab - we are recruiting a PhD student!

Application deadline: 20.12.2025
Starting date: from 1.04.2026

More info and application👇

Please share

@dib-unil.bsky.social @fbm-unil.bsky.social

#immunosky

5 months ago 4 3 0 2

Very happy to share that our research proposal has been funded by @snsf.ch ! 🎉
Grateful for the confidence in our work and excited for what this support will make possible. Big thanks to our amazing team and everyone who helped make it happen.

5 months ago 1 0 0 0

Happy to see our paper on the regulation of TLR biogenesis by CCDC134 featured in the JEM collection “Pattern Recognition Receptors and Beyond.” Check it out along with the other selected articles!

5 months ago 5 1 1 0
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Full room at the start of the 2nd Immunobiology symposium on pattern recognition receptors!
Looking forward to the great programme that we lined up for you together with @brozlab.bsky.social @martinon.bsky.social

#ImmunoSky

6 months ago 12 4 0 1

📣 Reminder 📣

There is still time to apply for this #job #opportunity in the field of #metabolic #diseases at the Department of Biomedical Sciences @fbm-unil.bsky.social @unil.bsky.social

👇👇👇

9 months ago 2 3 0 0
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Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters

11 months ago 15 10 1 1
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🚨 Abstract submission deadline: July 15th 2025🚨
Do not miss the opportunity to present your research: 10 selected short talks and an exciting poster session!
Register and submit your abstract here: wp.unil.ch/immunobiolog...

9 months ago 4 0 0 0
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Big congratulations to Cyrielle Hou (@dib-unil.bsky.social @fbm-unil.bsky.social) for receiving the Young Investigator Award at the 13th Meeting of the International Society of Systemic Autoinflammatory Diseases (ISSAID) in Paris! 🏆👏

And kudos to the organizers for a fantastic conference!

1 year ago 16 4 1 0
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The whole DIB would like to congratulate Pascal Schneider for his Lifetime Achievement Award!

More info: www.unil.ch/news/1749042...

9 months ago 11 4 0 0

We're looking forward to taking part in this meeting this October! JEM's Deputy Editor Gaia Trincucci (@gaiajexpmed.bsky.social‬) will be there – be sure to connect with Gaia to discuss your research and learn about publication 🔬💻✍️📄
#InnateImmunity #Immunobiology

10 months ago 4 2 0 0
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Le programme LEAF reconduit pour une nouvelle année 12 Laboratoires ont reçu une certification LEAF (Laboratory Efficiency Assessment Framework) pour leur participation au programme de mai 2024 à mai 2025.

🌿 Bravo aux 12 laboratoires certifiés LEAF @fbm-unil.bsky.social

👏 Arber Lab, Bagni Lab, Chatton Lab, Du Pasquier Lab, Jourdain Lab, LPA, M-Lab, Martinon Lab, Rebsamen Lab, Suter Lab, Thome Lab, Widmann Lab.
➡️ www.unil.ch/news/1747834...

#LEAF #recherche #durable

10 months ago 4 3 1 0

Register for this exciting meeting on Innate Immunity coming up in Switzerland! 🇨🇭

10 months ago 5 3 0 0

Interested in #InnateImmunity ? Register now to secure your spot — abstracts can be submitted later!
More info: wp.unil.ch/immunobiolog...

#ImmunoSky

11 months ago 2 3 0 2
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Research Highlight ✨|TASL has a key role in SLE

Read the original articles: bit.ly/3XLPzUm and bit.ly/41FilqV 📖

@rebsamenlab.bsky.social
@dib-unil.bsky.social

1 year ago 10 4 0 0

🚨Registrations are open🚨

Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.

Attendance is limited to 150 participants!

1 year ago 15 7 0 2

What do Pablo Picasso and Charles Janeway have in common? Both were interested in patterns of life. Janeway was focused on pathogen associated molecular patterns (PAMPs) that are detected by our immune system. But what are these patterns he refers to?

1 year ago 27 10 3 4
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TASL has a key role in SLE Nature Reviews Rheumatology, Published online: 28 February 2025; doi:10.1038/s41584-025-01232-xTwo studies provide insights into the function of TASL in the pathogenesis of systemic lupus erythematosus and highlight the therapeutic potential of targeting…
1 year ago 5 2 0 0

Delighted to see our latest paper selected as “Research Highlight” by @natrevrheumatol.bsky.social !
Original study @naturecomms.bsky.social : rdcu.be/d7lK5
#lupus
#innateimmunity
#autoimmunity
#ImmunoSky

1 year ago 13 5 0 0

🚨Registrations are open🚨

Join us in Lausanne Switzerland October 1-2 for an exciting symposium on innate immunity with oustanding invited speakers, short talks selected from submitted abstracts and poster sessions.

Attendance is limited to 150 participants!

1 year ago 15 7 0 2

I'm really excited to join the University of Geneva as associate professor. I look forward to expanding our research program in systems immunology within the Department of Pathology and Immunology and contributing to advance the Faculty's data science capabilities!

JOB OPPORTUNITY👇

1 year ago 31 4 6 0
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Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...

#Macrophages literally eat and live of dead #bacteria, while live bacteria stimulate inflammation. 🦠 viability is sensed by an mTORC1 metabolic switch.

Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social

www.nature.com/articles/s41...

1 year ago 52 13 1 1
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Chaque franc investi par l’État de Vaud dans l’Université de Lausanne en génère 4,7 dans le canton | État de Vaud L’activité de l’Université de Lausanne et sa présence dans le canton génèrent près de 9200 emplois et des retombées économiques de 1,73 milliard de francs. Une étude réalisée par…

Chaque franc investi par @etatdevaud.bsky.social dans @unil.bsky.social en génère 4,7 dans le canton
www.vd.ch/actualites/c...

1 year ago 5 3 0 0
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No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis. Leslie Domínguez Cadena and Antje Blumenthal discuss new study from @lbernaleau.bsky.social et al. @@rebsamenlab.bsky.social (https://buff.ly/3ZrE70d in Insights: https://buff.ly/4gwjt5N

1 year ago 4 2 0 0
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💡 At a joint press conference, the #SNSF and its ERI partners called on the Federal Council to abandon the planned cuts to #education, #research and #innovation in the "relief package 27", as they would have far-reaching consequences for the #economy and society.
➡️ https://buff.ly/3CTR2AM

1 year ago 42 15 0 5

Check out the Insights piece from A Blumenthal & L Dominguez Cadena on our discovery of CCDC134’s role in Gp96 stability and TLR biogenesis.
Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.

1 year ago 10 3 0 0
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This report investigates the effect of 21 variants in the hSLC39A8 gene experimentally on protein expression, localization, and uptake of metal ions, and computationally on dimerization stability RESOLUTE and REsolution the @supertifurgalab.bsky.social at CeMM https://buff.ly/4aHOzG3

1 year ago 2 1 0 0

Thrilled to see our recent paper on CCDC134 highlighted in @jem.org !
Grateful for the opportunity to contribute to this field and engage in meaningful discussions!

1 year ago 4 2 0 0
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New preprint from the lab! 🚨

🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease

by @marcellharhai.bsky.social @fbm-unil.bsky.social

A short thread 1/5

www.biorxiv.org/content/10.1...

1 year ago 38 20 5 5