🌍Learn more and apply www.rarefind-cofund.eu

👇 RAREFIND Supervisors cover a wide range of research topics — explore them below and on the website to find the one that sparks your curiosity the most.

Join a vibrant scientific community and play an active role in shaping the next discoveries of field!

🎓Are you looking to pursue a #PhD and make real impact in science?
The new RAREFIND #MSCA-COFUND PhD Program offers a unique opportunity to dive into cutting-edge #genetherapy and #celltherapy research with top-tier, interdisciplinary training across 22 leading labs at TIGEM and SR-Tiget.

🚀 Launch your career in advanced gene and cell therapies! 🚀

RAREFIND #MSCA-COFUND #PhD Programme opens its call for applications!

👉Know more and apply now: www.rarefind-cofund.eu

#RAREFINDPhD

Join our lab dibernardo.tigem.it for the #ERC-funded project DIMERCIRCUITS at @tigem.bsky.social. We are building synthetic gene circuits to power next-generation gene and cell therapies. We are looking for candidates with a PhD in #SyntheticBiology or related. Apply by email: dibernardo@tigem.it

#genetherapy #celltherapy #geneediting #genomics #molecularmedicine #proteindesign #syntheticbiology #AI-basedproteinengineering #computationalbiology #molecularimmunology

👉 Group Leader positions at TIGEM: www.tigem.it/newsroom/car...

👉 Group Leader positions at San Raffaele Telethon Institute for Gene Therapy (SR-Tiget): back.fondazionetelethon.it/uploads/2025...

👉 Postdoctoral Fellowships at TIGEM & SR-Tiget : back.fondazionetelethon.it/uploads/2025...

📢 Global Call for Scientific Talent – Join the #FondazioneTelethon Institutes!
We're looking for exceptional scientists to join #TIGEM and #SR-Tiget, two world-class research centers at the forefront of innovation in #genetherapy, #celltherapy, #geneediting, #genomics, and #molecularmedicine.

Back From #ASGCT!!!
TIGEM was pleased to take part in the ASGCT Conference 2025, where we had the opportunity to present our latest research and engage with the gene and cell therapy community!

@asgct.bsky.social

🌍 Attending #ASGCT2025 in #NewOrleans?
Don’t miss this Scientific Symposium hosted by the Coalition of International Gene Therapy Societies:

📌 Clinical Trials Around the Globe
🗓️ [Today, May 16th]
🕗 8:00 AM – 9:45 AM
📍 Room 293–296

#GeneTherapy #ASGCT #AAV #Retina #LiverGeneTherapy #RareDisease

#MPSAwarenessDay #MPSVI #GeneTherapy #RareDiseases #LysosomalDisorders #TIGEM #FondazioneTelethon #MEUSIX #ClinicalTrials #TranslationalResearch #HopeForRare

📈 Thanks to Fondazione Telethon, a new trial phase is underway — testing a higher dose and pushing us closer to real impact.

🙏 Deep gratitude to the MPS community for their strength and partnership.

🧬 Through the MEUSIX project with @biomarinpharma.bsky.social and @ec.europa.eu funding, we launched the first AAV-based gene therapy trial for MPS VI — showing promising safety and efficacy. Why gene therapy?
Because current treatments fall short. We aim for a one-time, lasting solution.

🎗️ It’s MPS Awareness Day.

At TIGEM, we stand with patients — especially those with MPS VI (Maroteaux-Lamy syndrome), a rare lysosomal disorder caused by ARSB gene mutations.

📢Applications for SEMM PhD program are now open! 🎉

We have 2 open positions at TIGEM in the PhD program in Systems Medicine.

Deadline: June 9th – don’t miss it!

Apply here: www.semm.it/education/ho...

#PhD #SystemsMedicine #TIGEM #SEMM #PhDOpportunity #BiomedicalResearch #CallForApplications

2025 International Mammalian Synthetic Biology Workshop (mSBW) The International Mammalian Synthetic Biology Workshop (mSBW) brings together leaders in synthetic biology with experts from other relevant fields to highlight and inspire cutting-edge synthetic biolo...

🗓️ August 11–12, 2025 | Irvine, California
🧠 Abstract submissions open until April 28!

👉 Info & registration: www.aiche.org/sbe/conferen...

#mSBW2025 #SyntheticBiology #GenomicMedicine

Excited for the International Mammalian Synthetic Biology Workshop (mSBW2025) — the only conference fully focused on mammalian synthetic biology! 🧬

Meet top experts, including @diegodibi.bsky.social, Genomic Medicine Program Coordinator at TIGEM and part of this year’s Organizing Committee.

#PompeDay #RareDiseaseResearch #GeneTherapy #Tigem #FondazioneTelethon #LisosomalStorageDisorder

Our journey began with science and compassion, inspired by the story of Rossella and a life-changing connection between Dr. Giancarlo Parenti and John Crowley in 2002 — a reminder that research, collaboration, and care can transform lives.

Read the full story here: www.tigem.it/newsroom/new...

from biomarkers discovery and lysosomal biology insights to innovative gene therapy and chaperone-based approaches.

Today we mark #InternationalPompeDiseaseDay, raising awareness for this rare genetic disorder. At TIGEM, supported by #FondazioneTelethon, we combine genetics, molecular biology, clinical research, and patient advocacy to advance new therapies —

Folliculin depletion results in liver cell damage and cholangiocarcinoma through MiT/TFE activation - Cell Death & Differentiation Cell Death & Differentiation - Folliculin depletion results in liver cell damage and cholangiocarcinoma through MiT/TFE activation

Excited to share the latest work of Pastore group!
Loss of Folliculin drives liver cell damage and cholangiocarcinoma via MiT/TFE activation.

👉 Read the full article: doi.org/10.1038/s414...

#StructuralBiology #AI #GeneTherapy #RareDiseases #ProteinDesign

AI, Biophysics & Rare Diseases: Andrea Pasquadibisceglie’s Mission at TIGEM

💡 "TIGEM gave me the chance to return to Italy and make a difference. I want to push the boundaries of research on rare diseases."

Big things ahead for Andrea and his mission to advance molecular therapies! 🚀

Read the interview here: www.tigem.it/newsroom/new...

🔬 From Sweden to Italy: @andpdb.bsky.social is bringing his expertise in Computational Structural Biology back home!

After working at #KTH (Stockholm), he’s now a Staff Scientist at TIGEM, using AI and physics-based models to design hyperactive enzymes that improve gene therapy for rare diseases.

#hydeparkcoroglio #research #biotechnology #technologytransfer… | Tigem 🎉 We are thrilled to share the success of the latest #HydeParkCoroglio event, featuring our esteemed Prof. Alberto Auricchio, Scientific Director at Tigem in…

A huge thank you to everyone who participated! Let’s keep building bridges between science, finance, and the future. 🌍✨

#HydeParkCoroglio #Innovation #ScienceAndFinance #Collaboration #Future

Read more here: www.linkedin.com/feed/update/...

He shared valuable insights on #research and #biotech, exploring the potential of innovation and the challenges ahead. The discussion also covered key financial strategies supporting cutting-edge research, demonstrating how #techtransfer can turn discoveries into real-world impact.

🚀 Exciting moments at #HydeParkCoroglio!

Our Prof. Alberto Auricchio, Scientific Director at Tigem in Pozzuoli, took the stage for an inspiring talk.

Retinal gene therapy for Stargardt disease with dual AAV intein vectors is both safe and effective in large animal models AAV-intein-based gene therapy for Stargardt disease proves to be safe and efficacious in large animal models.

🔬 AAV-based gene therapy for Stargardt disease is safe and effective in large animal models

A work of #IvanaTrapani and #AAVantgardeBio !!!

📄 #ScienceAdvances | doi.org/10.1126/sciadv.adt9354

#GeneTherapy #Ophthalmology #AAV #Stargardt #VisionResearch

Cortico-striatal circuit mechanisms drive the effects of D1 dopamine agonists on memory capacity in mice through cAMP/PKA signalling - Nature Communications D1 receptor agonists bidirectionally regulate working memory capacity (WMC). Here, the authors show that low doses enhance WMC by activating cAMP/PKA in the striatum, whereas high doses impair it via ...

Low doses? 🎯 Boost memory.
High doses? 🚫 Impair it.

A game-changer for cognitive enhancement strategies in schizophrenia and beyond!

🔗Read the full article here: doi.org/10.1038/s414...

#Neuroscience #Memory #Dopamine #Striatum #PKA #Schizophrenia #SystemsPharmacology