Off-label #antipsychotic use is widespread among older adults, Finnish study finds
www.eurekalert.org/news-release...

CIHI | 24% or all long-term care residents in CAN received an #antipsychotic meds 𝚠̲𝚒̲𝚝̲𝚑̲𝚘̲𝚞̲𝚝̲ ̲𝚊̲ ̲𝚍̲𝚒̲𝚊̲𝚐̲𝚗̲𝚘̲𝚜̲𝚒̲𝚜̲ ̲𝚘̲𝚏̲ ̲𝚙̲𝚜̲𝚢̲𝚌̲𝚑̲𝚘̲𝚜̲𝚒̲𝚜̲ - rates higher than US, AUS and SWE. Best practice is < 15%.

Inappropriate use carries serious risks: adverse reactions, cognitive decline, falls and even death. #NotBestPractice

Use of antipsychotic meds in nursing homes remains flat Maine has the 12th highest rate of long-term nursing home residents on antipsychotics, which carry health risks.

One in five long-term nursing home residents in #Maine are still receiving #antipsychotic meds, despite statewide efforts to reduce reliance on them, which can come with health risks for older adults. Read more on how this affects seniors at the link👇

themainemonitor.org/antipsychoti...

New data reveal diagnosis-specific #antipsychotic prescribing patterns: SGAs dominate overall; clozapine and LAIs cluster in schizophrenia; quetiapine is favored in psychotic bipolar disorder and psychotic depression; risperidone in delusional disorders.

🔗Read more: journals.lww.com/psychopharma...

Integrated #Multiomics showed that higher phosphatidylcholine & sphingomyelin levels correlate with better #Antipsychotic efficacy, underscoring the role of phospholipid metabolism in anti-psychotic effect in #Schizophrenia. @pku1898.bsky.social

#OpenAccess: doi.org/10.1038/s413...

Xanomeline-trospium: defining its place among the current antipsychotic landscape | Acta Neuropsychiatrica | Cambridge Core Xanomeline-trospium: defining its place among the current antipsychotic landscape - Volume 37

🔗 Read the full paper: doi.org/10.1017/neu....
#Antipsychotic #Cobenfy #Xanomeline #CME

Prescriber-recorded indications for antipsychotic use in children and adolescents in Spain, 2015–2023: a population-based, real-world study - European Child & Adolescent Psychiatry The use of antipsychotics (APs) in children and adolescents has increased notably worldwide, often beyond approved indications. However, most real-world studies lack direct information on the clinical...

Just published online and #openaccess: Prescriber-recorded indications for #antipsychotic use in children and adolescents in Spain, 2015–2023: a population-based, real-world study by García-Sempere et al:
link.springer.com/article/10.1...
#childpsychiatry #adolescentpsychiatry #ECAP

Excited to share we’ve been awarded £215k from NIHR @nihr.bsky.social to continue our research on #antipsychotic use in #dementia 💡

Next up: analysing trial data, electronic health records & lived experiences to optimise safe prescribing.

We’ll be recruiting soon - watch this space for adverts!

Transcriptomic and proteomic analyses of SH-SY5Y neuroblastoma cells treated with amisulpride | Acta Neuropsychiatrica | Cambridge Core Transcriptomic and proteomic analyses of SH-SY5Y neuroblastoma cells treated with amisulpride

These findings provide a deeper mechanistic understanding of its clinical effects and reveal potential treatment targets for schizophrenia.

🔗Find more on: doi.org/10.1017/neu....
#MolecularBiology #antipsychotic

This is the largest systematic review to date examining disruptions in glycemic control associated with #antipsychotic drugs. We show that that antipsychotic drug treatment significantly disrupts glucose homeostasis independent of exposure time, dose, diagnosis, and weight gain.

#Medsky🧪 #neurosky #publichealth #Clozapine is the only Rx approved by FDA for #Trichotillomania . It is considered the gold standard & a 1st-line #antipsychotic for TRS in treatment guidelines, incl those published by the APA.

In discovery that could guide dvlpmnt of next-generation #Antidepressants & #Antipsychotic medications, @mountsinainyc.bsky.social researchers Daniel Wacker, et al. have dvlpd new insights into how a critical brain receptor works at molecular level. PRESS RELEASE 👉 www.mountsinai.org/about/newsro...

The Difference Between A Manic and A Psychotic Episode I realized that I trailed off in the middle of my last entry. I started talking about how I got triggered and just sort of ended the entry after that, ha!  Sorry y’all! So, now I want to pick …

#adelusionalpredisposition

#mentalillness #disability #handicapable #invisibleillness #schizoaffectivedisorder #schizophrenia #bipolar #mania #psychosis #episode #anxiety #hallucinations #difference #stigma #negative #symptoms #confusion #distressing #missingtime #antipsychotic #recklessspending

I've literally been babbling to myself so much more lately and lowkey starting to hallucinate again uwu thanks daddy Trump for making the cost of my previous #antipsychotic shoot up from $1500 to $4500 <3

&& friends. If you are on any #SSRI or #antipsychotic meds stay hydrated and stay cool!

There are a bunch of meds that make you heat intolerant/unable to regulate body temperature. Check yours with a quick online search.

Be safe 💚✨

#Spoonie #ChronicIllness #Disabled #ChronicPain #Community

Started a new antipsychotic
Saw an awesome moth

#moth #antipsychotic

Fantastic clinical session with final panel discussion at #BAP2025 on “Myth-busting the (should not be) controversial treatments in psychiatry: A review of clinical evidence” chaired by @carminepariante.bsky.social

#valproate
#antipsychotic
#clozapine
#ECT
#livedexperience
@bapsych.bsky.social

Parts of My Verbal Auditory Hallucinations I had a difficult realization over this last week. That most of the “neighbors” that I hear talking amongst themselves on my walks are still hallucinations. *sigh* I had noticed that there’s usuall…

#adelusionalpredisposition

#verbalauditoryhallucinations #mentalillness #mentalhealth #psychosis #voices #delusions #episodic #schizoaffectivedisorder #growth #anosognosia #hallucinations #antipsychotic #therapy #delusions #stigma #schizophrenia #bipolar #invisibleillness #handicapable #disability

⚠️Recall Alert-Medication⚠️"JAMP "-Risperidone⚠️

PLEASE Share

View Recall-Health Canada's Website
tinyurl.com/4ykpwm9s

#Recall #RecallAlert #Medication #Risperidone #Risperdal #Antipsychotic #BipolorDisorder #Schizophrenia #Industry #HealthCare #Pharmacy #Pharmacists #Qubec #Psychiatrist #Canada

Cobenfy is a cholinergic for #schizophrenia, but what about other cholinergics (anti-dementia: donepezil, galantamine; anti-nicotine: varenicline)?

They didn't help psychosis in new analysis, but one in the pipeline has #antipsychotic potential: Emraclidine
pubmed.ncbi.nlm.nih.gov/40314158

Stahl's focus on these legacy medications is a quiet homage to efficacy—to drugs that may be complex to manage, but whose impact is unparalleled when used correctly.

#APA2025 #Psychiatry #Clozapine #MAOIs #StephenStahl #Schizophrenia #Psychopharmacology #psychiatrist #antipsychotic

Xanomeline/trospium (Cobenfy) is the first non-dopaminergic #antipsychotic.

Here we see its pivotal three trails in #schizophrenia reanalyzed, revealing a meaningful benefit in agitation:
ncbi.nlm.nih.gov/pubmed/40215379

But does it improve cognition? Find out in tomorrow's post.

Sparking Change in the Appropriate Use of Antipsychotics Awards Program

Learn more about how your LTC team can optimize care through the Sparking Change in the Appropriate Use of Antipsychotics Awards Program:
buff.ly/a76ncf1

It's not too late to register (deadline is Oct 1, 2025)!

Also check out our #antipsychotic deprescribing tools here:
buff.ly/Dbw1Oj3

So it turns out if you miss one (1) day of your #antipsychotic, you can have a #seizure. Found out the hard way. I also found out it makes me incredibly horny 😈 🤔

Don't worry I'm not out here missing meds on purpose. The pharmacy fucked up.

#Geodon

Research Assistant - QMUL Jobs ID: 5802. Title: Research Assistant . Application Deadline:

Research Assistant #job opportunity conducting a scoping review mapping out evidence regarding who could discontinue #antipsychotic medications with the lowest risk of relapse and with the greatest chance of benefit. Closes 5/5/25 Pls share! qmul-jobs.tal.net/vx/mobile-0/... @qmul-wiph.bsky.social

Original post on mastodon.social

It's disturbing to me how many people I meet who are on #antipsychotic drugs when they have absolutely no #disorder or #health condition that couldn't be treated in a different way.

Almost everyone I met who was #homeless or poor, who had state #insurance which didn't give access to great […]

💊 Several randomized controlled trials (RCTs) have compared the effectiveness, efficacy, and safety of #antipsychotic #monotherapy (APM) versus placebo in patients with major depressive disorder, this #review conducts a meta-analysis to examine this topic.

💻 www.thieme-connect.com/products/ejo...

Reducing health inequalities in antipsychotic reduction for people living with dementia in care homes at University of Bradford on FindAPhD.com PhD Project - Reducing health inequalities in antipsychotic reduction for people living with dementia in care homes at University of Bradford, listed on FindAPhD.com

Opportunity for a self-funded PhD @uniofbradford.bsky.social and working with
@yhpsrc.bsky.social on how to reduce #antipsychotic use in #dementia

www.findaphd.com/phds/project...

Original post on mastodon.social

You should really think twice about taking #Antipsychotic drugs unless you ABSOLUTELY need them.

Recent studies have shown that they caused brain damage, due to oxidative stress put on the brain by messing with dopamine, reducing gray matter, or otherwise, neurons for those unsure about what […]