Here you can see a cryoEM structure of human Apolipoprotein B 100 bound to LDL receptor (PDB code: 9BDT)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #apolipoprotein #cholesterol #membrane #receptor #LDL #cryoem

Scientists discover why the flu is more deadly for older people Scientists have discovered why older people are more likely to suffer severely from the flu, and can now use their findings to address this risk.

Reason the #flu is more deadly for older people ...

| #Influenza | #infection | #apolipoprotein | #inflammation | By @uniofnottingham.bsky.social via @sciencex.bsky.social

✨Closing Day 1 of ISMND NextGen 2025...
S2: #Apolipoprotein and lipid contribution to #AlzheimersDisease

Host: Julia TCW & Margareta Kurkela

Speakers:
🔹 Akhil Pallerla
🔹 Amanda McQuade
🔹 Sascha Koppes-den Hertog
🔹 Xu Chen
🔹 Georgia Nolt
🔹 Isaiah O. Stephens

Structural analyses define the molecular basis of clusterin chaperone function Nature Structural & Molecular Biology - The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions...

Curious about the structure and functional analysis of one of the most abundant and enigmatic extracellular #chaperones and one of the highest genetic risk factor for developing late onset #Alzheimer’s disease? Check out our paper on Clusterin/ApoJ!
#proteostasis #apolipoprotein
rdcu.be/ezRLv

Who knew #cholesterol transport could look this cool?

Rendered in @blender3d.bsky.social using #MolecularNodes
Featuring #Apolipoprotein B-100 (PDB: 9BDT @rcsbpdb.bsky.social) hugging a #lipid droplet, with #LDL receptors hitching all over.
April 2025 Molecule of the Month #illustration #SciArt

Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors - Nature Nanotechnology In this study, the authors present optimization and efficacy testing of apolipoprotein-based lipid nanoparticles for delivering various nucleic acid therapeutics in vivo to immune cells and their prog...

New Paper Online:

Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors.

www.nature.com/articles/s41...

#Apolipoprotein #Nanotechnology #RNA

Apolipoprotein B-containing lipoproteins in atherogenesis - Nature Reviews Cardiology In this Review, Borén and colleagues present insights into the role of apolipoprotein B-containing lipoproteins in atherogenesis, with an emphasis on the mechanisms leading to atherosclerotic plaque i...

#apob and atherogenesis

'Subendothelial retention of LDL and other #apolipoprotein B-containing lipoproteins is the primary trigger for the development of atherosclerosis'

#lipids #LDL #lipidology #lipoprotein #cvprev #medsky #lpa

apob < 45 seems appealing

www.nature.com/articles/s41...

🙌🏾@ISMMSKidney co-leads one of 13 network hubs of @ApolloNetwork13, a national observational study assessing impact of #apolipoprotein L1 (#APOL1) genetic variants on #kidneytransplant outcomes
• Mount Sinai is proud to display badge🏅to honor #APOLLO ▶️

bit.ly/3Lc0JJO