Hybrid Genome Assembly and Annotation of the Basidiomycete Fungus Candolleomyces candolleanus Strain CMU-8613 Using a Cost-Effective Iterative Pipeline

#Candolleomyces
#genome
#hybridassembly
#pipelineperformancecomparison
#BGCs
#CAZymes
#matingtype

www.mdpi.com/1422-0067/27...

Thank you @mmzdouc.bsky.social for detailing our work!
In this study we highlight conserved & unique #clusters and link 5 #lichen #metabolites to #BGCs.
Thank you @marnixmedema.bsky.social & all the collaborators 🥂!
#PKSs #RiPPs #secondaryMetabolism #depsides #fungi #MS #omics

Beautiful morning in London. Excited to attend the 2025 British Gyn Cancer Society #BGCS meeting.

Ultra-deep long-read metagenomics captures diverse taxonomic and biosynthetic potential of soil microbes Background Soil ecosystems have long been recognized as hotspots of microbial diversity, but most estimates of their complexity remain speculative, relying on limited data and extrapolation from shall...

New preprint: we sequenced one soil sample with ultra-deep hybrid metagenomics and found…
→ 800+ MAGs
→ 11,000+ BGCs
→ and still nowhere near saturation.
Soil is wild.
Preprint here: www.biorxiv.org/content/10.1...
#microbiome #metagenomics #BGCs #naturalproducts #secmet

Our paper on #biosynthetic genes coding for ribosomal #peptides is out now: rdcu.be/ekux7! We present the 1st report of #RiPP-BGCs presence & diversity in #lichens. Spoiler: they’re ubiquitous & make up ~15–20% of #BGCs. #secondarymetabolites #fungi #genomeMining

" #PacBio HiFi #longread sequencing offers comprehensive insights into deadwood decomposition processes by advancing the identification of functional features involving multiple genes. It represents a robust tool for unraveling novel #microbial genomes in complex ecosystems." #microbiome #MAGs #BGCs

Is your bacterial strain unique? New tools in zol let you easily check the conservation/novelty of prophages, plasmids, & BGCs in a focal sample's genome against a database of target genomes (e.g. all other genomes from the same species) #phages #plasmids #MGEs #BGCs github.com/Kalan-Lab/zol

New in zol v1.3.10: fai generates a XLSX spreadsheet with automatic formatting showing the closest hits of a query gene cluster in the target genomes database. This allows users to easily perform manual filtration before progressing to zol!

github.com/Kalan-Lab/zol

#secmet #bgcs #phages