‍𝗖𝗶𝗿𝗰𝘂𝗹𝗮𝘁𝗶𝗻𝗴 𝗰𝗮𝗹𝗽𝗿𝗼𝘁𝗲𝗰𝘁𝗶𝗻 𝘀𝘂𝗽𝗽𝗼𝗿𝘁𝗶𝗻𝗴 𝗽𝗿𝗲𝗰𝗶𝘀𝗶𝗼𝗻 𝗺𝗲𝗱𝗶𝗰𝗶𝗻𝗲 𝗶𝗻 𝗽𝗻𝗲𝘂𝗺𝗼𝗻𝗶𝗮. The INSPIRE study highlights the potential of #calprotectin for risk stratification and treatment monitoring in patients hospitalised with pneumonia receiving Anakinra.

Read more👉 www.gentian.com/news/calprot...

AI generated: for illustartion only.

Serum #calprotectin identified as a promising biomarker for multiple sclerosis (MS). Levels are significantly higher in patients than healthy controls. Elevated levels specifically correlate with the relapsing-remitting (RRMS) subtype and lower disability scores.

journals.lww.com/md-journal/f...

📰𝗡𝗲𝘄𝘀𝗹𝗲𝘁𝘁𝗲𝗿 𝗼𝘂𝘁: 𝗖𝗶𝗿𝗰𝘂𝗹𝗮𝘁𝗶𝗻𝗴 𝗰𝗮𝗹𝗽𝗿𝗼𝘁𝗲𝗰𝘁𝗶𝗻 – 𝘁𝗵𝗲 𝗽𝗼𝘄𝗲𝗿 𝘁𝗼 𝗮𝘀𝘀𝗲𝘀𝘀 𝗶𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗶𝗼𝗻. Why is circulating hashtag#calprotectin gaining so much attention in rheumatology? In our latest GCAL® newsletter, we share insights from recent conferences, new literature, and real-world clinical experience showing how calprotectin is shaping inflammation monitoring in Inflammatory Rheumatic Diseases hashtag#IRDs

Last newsletter of the year.

𝗖𝗶𝗿𝗰𝘂𝗹𝗮𝘁𝗶𝗻𝗴 𝗰𝗮𝗹𝗽𝗿𝗼𝘁𝗲𝗰𝘁𝗶𝗻 – 𝘁𝗵𝗲 𝗽𝗼𝘄𝗲𝗿 𝘁𝗼 𝗮𝘀𝘀𝗲𝘀𝘀 𝗶𝗻𝗳𝗹𝗮𝗺𝗺𝗮𝘁𝗶𝗼𝗻.
#Calprotectin #RheumSky #IRD

www.linkedin.com/posts/gentia...

Left: Structure of the S100A8 (magenta)/S100A9 (cyan) heterodimer of calprotectin bound to zinc ion (sphere). Right: Close-up of the histidine residues (orange) coordinating zinc ion. PDB ID 8SJC. CC BY SBGRID.

How one protein tail helps starve bacteria of zinc: a publication highlight chosen by recent Ph.D. graduate @keandreyam.bsky.social , Ph.D. (congratulations KeAndreya!) from the laboratory of @chazinwalter.bsky.social to highlight.

Read more here: buff.ly/UNLUraF

#SBGrid #Calprotectin

Exploring the Relevance of S100A8 and S100A9 Proteins in Preeclampsia: A Narrative Review

#Calprotectin

www.mdpi.com/1422-0067/26...

The role of inflammation in acute coronary syndrome: A systematic review on biochemical inflammatory assessment and anti-inflammatory therapies Low-grade inflammation is a key driver of the pathogenesis and complications of acute coronary syndromes (ACS), playing a central role in plaque development and destabilization. This systematic review...

The role of inflammation in acute coronary syndrome: A systematic review on biochemical inflammatory assessment and anti-inflammatory therapies

#CardioSky #calprotectin

www.nmcd-journal.com/article/S093...

Calprotectin in neonatal infections - jENS Congress 2025 New evidence will be shared on the role of blood calprotectin in the early diagnosis of neonatal infections.

𝗡𝗲𝘄 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗶𝗻𝘁𝗼 𝗲𝗮𝗿𝗹𝘆 𝗱𝗶𝗮𝗴𝗻𝗼𝘀𝗶𝘀 𝗼𝗳 𝗻𝗲𝗼𝗻𝗮𝘁𝗮𝗹 𝗶𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻𝘀 At this year’s joint European Neonatal Societies #jENS2025 Congress, new evidence will be presented on the role of serum #calprotectin in improving early diagnosis of neonatal infections.

www.gentian.com/news/calprot...

The C‐terminal extension of calprotectin mediates zinc chelation and modulates Staphylococcus aureus biomass accumulation Calprotectin (CP) is an S100A8/S100A9 heterodimer that plays an important role in nutritional immunity at the host–microbe interface. CP combats Staphylococcus aureus growth by sequestration of zinc ...

My mentors @vubasicsciences.bsky.social encouraged the #CollaborativeScience behind this work from the Chazin and Skaar labs, with co-author Randy Perera. Excited to have published this work @proteinsociety.bsky.social studying #Calprotectin and #StaphAureus onlinelibrary.wiley.com/doi/full/10....

✨We welcome you to read the interesting article: Proteomic Analysis of Sputum from Patients with Active Tuberculosis, by Endrei Marcantonio et al.

🔗See more details at www.mdpi.com/2227-7382/13...

#proteomics #proteomes #proteoform #tuberculosis #calprotectin #sputum #OpenAccess

Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy #calprotectin #MECFS #LongCovid

bsky.app/profile/rene...

Great depate at #PReS2025 between Dirk Föll and Joost Swart. Engaging and entertaining to follow those 2 outstanding speakers exchanging arguments.

The futures will hopefully be personalised medicine also for IRDs and biomarkers will play a crucial role.

#RheumSky #calprotectin

Year in review at #PReS2025 highlighting again the new Still's recommendations, endorsing biomarkers in diagnosis including #calprotectin

Visit us at booth 4 to learn about Gentian GCAL an automated calprotectin assay.

#RheumSky

👉 Visit Gentian at Booth 4 at #PReS2025 to discover how GCAL® #calprotectin improves early inflammation detection, flare prediction, and treatment monitoring in pediatric rheumatology.

💥 New biomarker insight for #pulmonaryembolism
#Calprotectin is up in PE and tracks with worse RV function (↓TAPSE, ↓RV-Sm). No link to D-dimer or troponin.

Potential new RV stress marker?

pmc.ncbi.nlm.nih.gov/articles/PMC...

New biomarkers (of the 2024 recommendations) remain underutilized. S100 proteins ( #calprotectin ) are used by only 27% and 40% of respondents indicated lack of access.

But calprotectin is available as automated assay for labs (Siemens, Beckman and open channel).

pubmed.ncbi.nlm.nih.gov/40629829/

My calprotectin is at 23 !!!!
23 ! Juts a 2 and a 3 !!!!!!!!!! 😃😃😃😃😃 I never ever had it so low. I’m happy today.
But I know everything can change in just months so I stay focus and prudent.

#crohns #crohn #rch #uc #ulcerativecolitis #mici #ibd #calprotectin

The role of S100A9 as a diagnostic and prognostic biomarker in septic shock Background Sepsis is a severe and potentially fatal systemic condition marked by excessive immune defense against infection. Within this research, we explored the serum concentration of S100A9 during ...

👉S100A9 (subunit of #calprotectin) showed high sensitivity in detecting septic shock and forecasting clinical outcomes.

journals.plos.org/plosone/arti...

Calprotectin shows potential as a biomarker for atherosclerotic CV disease risk Calprotectin could serve as a biomarker for atherosclerotic cardiovascular disease beyond the current traditional cardiovascular risk factors.

#MedNews - Calprotectin could serve as a biomarker for #ASCVD beyond the current traditional cardiovascular risk factors.

Read the full story 👉 buff.ly/GxJoGHM

#CardioSky #calprotectin

🔥 Sepsis study: Dual targeting of CitH3 & #Calprotectin slashes inflammation, NETosis, & lung damage in mice. 🧬 The combo boosts survival in P. aeruginosa sepsis—offering a novel path to immunomodulation without compromising defense.

journals.sagepub.com/doi/10.1177/...

🧬 New study shows circulating #calprotectin could be a key biomarker in systemic sclerosis. 📈 Strong links found with disease activity, digital ulcers, and interstitial lung disease. Suggesting a potential to help track #SSc progression and complications.

#RheumSky

www.mdpi.com/1422-0067/26...

Calprotectin and Atherosclerotic Cardiovascular Disease This population-based cohort study examines the prospective association between circulating calprotectin and atherosclerotic cardiovascular disease as well as the mechanistic contributions of calprote...

Calprotectina puede funcionar como un biomarcador mecanicistamente informado para la enfermedad CV aterosclerótica, independientemente de los factores de riesgo CV tradicionales y contemporáneos #calprotectin #ASCVD jamanetwork.com/journals/jam...

How Neutrophil Calprotectin Unmasks Future Atherosclerotic Heart Disease Risk | Newswise This hidden danger can cause ischemic strokes as well as cardiovascular-related deaths

“The team’s work showed that #calprotectin negatively impacts blood vessel cell #health, reducing the production of nitric oxide (which keeps #arteries flexible) & likely promoting scarring & damage in #coronary arteries.”: buff.ly/yXkQbOD

via @newswise.bsky.social
#cardiovascular

Calprotectin and Atherosclerotic Cardiovascular Disease This population-based cohort study examines the prospective association between circulating calprotectin and atherosclerotic cardiovascular disease as well as the mechanistic contributions of calprote...

🤔New #CirculatingCalprotectin Publication: ''Calprotectin has the potential to be a mechanistically informed biomarker for ASCVD, independent of traditional and contemporary cardiovascular risk factors and biomarkers.''

jamanetwork.com/journals/jam...

#RheumSky #Calprotectin

Can we improve how to monitor Inflammatory Bowel Disease? Researchers at University of Glasgow are looking for people living with IBD and who have undergone poo testing as part of their clinical care to complete a short online survey to help them develop way...

Our group have studied whether stool #calprotectin vs. #QFIT (that can detect blood used as screening for bowel cancer) to monitor #IBD . 💩

We are looking for the 'patient voice' in our study, so very grateful for your time, share and RT!
crohnsandcolitis.org.uk/get-involved...

Excited to announce the relaunch of www.calprotectin.com – our dedicated resource hub on circulating #calprotectin for healthcare and laboratory professionals working in the field of inflammatory #rheumaticdiseases.

#RheumSky

Serum Calprotectin (S100A8/A9) in Diagnosis, Monitoring, and Prognosis of Rheumatic Diseases <p><strong>Available On-Demand</strong></p> <p>Serum calprotectin plays a critical role in the pathogenesis of rheumatoid arthritis (RA), as it triggers chemotaxis, phagocyte migration, and modulation...

🗣️Webinar by Prof. Dr. Marija Jeluŝić now available on demand 🌐

Serum Calprotectin (S100A8/A9) in Diagnosis, Monitoring, and Prognosis of Rheumatic Diseases

selectscience.streamgo.live/serum-calpro...

#RheumaSky #Calprotectin #Inflammation

Serum Calprotectin (S100A8/A9) in Diagnosis, Monitoring, and Prognosis of Rheumatic Diseases <p><strong>Friday, March 28, at 15:00 GMT / 16:00 CET / 11:00 EDT / 08:00 PDT</strong></p> <p>Serum calprotectin plays a critical role in the pathogenesis of rheumatoid arthritis (RA), as it triggers ...

💡Sign up for the free accredited webinar about #calprotectin as a biomarker in rheumatic diseases!

Join Prof. Dr. Marija Jeluŝić as she discusses the role of serum calprotectin in the diagnosis, monitoring, and prognosis.

📆 March 28th

#RheumaSky

selectscience.streamgo.live/serum-calpro...

Highlights from the breakout session: vasculitis in paediatric rheumatology Abstract. The 21st International Vasculitis Workshop, held in Barcelona, Spain, from April 7 to 10, 2024, highlighted advances in pediatric vasculitis, foc

Highlights from Breakout session in vasculitis in paediatric rheumatology. Including results of #Calprotectin (S100A8/A9) in IgA vasculitis, where elevated levels were significantly associated with active disease.

academic.oup.com/rheumatology...

#ReuhmaSky #CirculatingCalprotectin

Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...

Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy #calprotectin #MECFS #LongCovid

www.nature.com/articles/s42...

#CORA2025 started in beautiful Venice and an extraordinary congress location.

#Calprotectin #RheumSky