Save the date! 15th Activity Based Protein Profiling meeting #ABPP2027 is in Leiden, 2-4th June 2027. Join the mailing list for program updates and rego: www.universiteitleiden.nl/en/science/led3/abpp2027
#chembiol #proteomics #ABPs #Chemicalprobes @led3hub.bsky.social @leidenscience.bsky.social
Breakthrough Aurora A PROTAC on the Chemical Probes Portal ⭐⭐⭐⭐
CCT400028 @icr.ac.uk London overcomes the hook effect, delivers >120h stability, is highly selective, and includes a matched inactive control.
Powering paediatric cancer research.
#ChemicalProbes #PROTAC
Read more 👇
A successful PROTAC Hackathon hosted at the@crick.ac.uk:
• 34 participants
• 24 reviews generated
• 100% reported improved understanding
Organised by the Chemical Probes Portal with academic & industry collaboration.
Next Hackathon: EUFEPS–SITELF 2026 in Naples 🇮🇹
#ChemicalProbes #PROTACs #EUFEPS
Excited about tomorrow!
A full house at @crick.ac.uk for the 9th Chemical Probe Hackathon, with experts from GSK, @icr.ac.uk & TheCrick
working with PhDs & postdocs to review chemical probes and improve research quality.
#ChemicalProbes #ChemBio #OpenScience #Hackathon
We brought together 22 researchers & 6 experts for a full day of evaluating GPCR and ion channel probes — and completed 26 reviews!
Lots of learning, laughter, and deep discussions about what makes a great chemical probe.
#ChemicalProbes #OpenScience #DrugDiscovery #GPCR #IonChannels
We’re in Oxford today for the 1st UK Chemical Probes Hackathon! 🎯
Postdocs & PhD students join experts to assess GPCR probes and improve research quality.
Hosted by @ChemProbes + @UniofOxford
#ChemicalProbes #GPCRs #DrugDiscovery
🎉 The Chemical Probes Portal turns 10!
We’re honoured to be featured in Dr Dan Erlanson’s latest Practical Fragments blog, reflecting on a decade of advancing chemical biology and open science.
🔗 Read the blog: practicalfragments.blogspot.com/2025/08/the-...
#ChemicalProbes #Target2035
🧪 As a complement to CCT251545 and CCT251921, the study also highlights MSC2530818 as a valuable orthogonal CDK8/19 probe, further strengthening confidence in on-target effects and enabling robust mechanistic studies.
#ChemicalProbes #CDK8 #TargetValidation
New @ACSChemBio study provides strong evidence that the effects of CDK8/19 inhibitors CCT251545 and CCT251921 are on-target.
Using CRISPR knockouts + phosphoproteomics, authors show transcriptional & antitumor effects depend on CDK8/19.
🔗 pubs.acs.org/doi/10.1021/...
#ChemicalProbes #CDK8 #OnTarget
🔍Specialized #ChemicalProbes are central to dfPPI, capturing dysfunctional interactions—trapping thousands of protein interactors, enabling precise identification of disease-driven interactome changes. #MassSpec #Proteomics (4)
Huge congratulations to the first MSc #graduate from the Kavanagh lab (and future #PhD ) @leidenscience.bsky.social @led3hub.bsky.social Could not be more proud of Jakob and his hard work pushing forward the development of #chemicalprobes to modulate #immunology #chembio #STEMed
The Chemical Probes Portal now covers 601 protein targets, expanding resources for chemical biology & drug discovery! 🧪🔬 New high-quality probes target DCTPP1, MASTL, HCN1, plus E3 ligases & PROTACs for protein degradation. Learn more: www.chemicalprobes.org/news/600-tar... #ChemicalProbes
We provide a new checklist for selecting & using chemical probes—valuable for researchers, journal editors, reviewers, and vendors. Ensure best practices in chemical biology! 🧪✅
🔗 Supplementary material: ars.els-cdn.com/content/imag...
#ChemicalProbes #DrugDiscovery #ChemicalBiology
Our Cancer Cell Commentary reviews progress on chemical probes since Arrowsmith et al. (Nat Chem Biol 2015) and the launch of the Chemical Probes Portal. We highlight key issues, propose solutions, and outline a path to a quality probe for every human protein. #ChemicalProbes
🔬 The Chemical Probes Hackathon is underway in Vienna!
Experts from academia & industry, along with international students, are reviewing kinase inhibitors & PROTACs—advancing biomedical research through collaboration.
Excited to see today’s findings! 🚀 #EUFEPS #chemicalprobes
More than 25 years after FXR agonist GW4604 was described by now @thesgc.bsky.social scientist Tim Willson, it is still being used in cutting edge papers. High quality #ChemicalProbes are expensive to discover, but they’re the gift that keeps on giving.
www.nature.com/articles/s41...
Registration: chemicalprobes.org/hackathons/eufeps2025
📧 Questions? hackathon@chemprobes.org
@Chemical_probes
#ChemicalProbes #Hackathon #ScientificResearch #EUFEPS
Can't wait for 4 days of #chembiol #medchem #chemicalprobes #drugdiscovery and #chemoproteomics
@RACInational
#MCCB2025 Great line of #science and catching up with old friends in #NT
bit.ly/3PNkUl6
What do you get when you put @aledmedwards.bsky.social and me in front of a microphone? You get a great conversation about #openscience, #ChemicalProbes, and a crazy goal about creating tool compounds and probes for every protein in the human proteome by 2035. creators.spotify.com/pod/show/tar...
Last chance to register for #ABPP2025 ! Don't miss an incredible line up of talks on #proteomics #chemicalprobes #drugdiscovery #immunology #cancer plus an #earlycareer research. 30th March - 2nd April in London. Registration www.eventcreate.com/e/abpp2025/
Designing compounds with robots and AI will not accelerate drug discovery says @dereklowe.bsky.social (agreed). But designing great #ChemicalProbes using AI (eventually) and putting them in the hands of biologists just might. #Target2035
www.chemistryworld.com/opinion/robo...
🚨 New publication alert! 🚨
Our latest update on the Chemical Probes Portal is live! 🎉
📜 Read the paper: doi.org/10.1093/nar/...
🔍 Learn about our expanded content + improved functionality in the 2024 Nucleic Acids Research Database Issue.
#ChemicalProbes #BiomedicalResearch #OpenScience
