Recent Advances and Evolving Strategies of Photothermal Immunotherapy in Pancreatic Cancer Treatment This review outlines the current treatment strategies and advances of pancreatic cancer, with a focus on the latest evolving research progress based on photothermal therapy and immunotherapy. Despite...

#Review in #MedComm_Biomaterials_and_Applications

Recent Advances and Evolving Strategies of Photothermal Immunotherapy in Pancreatic Cancer Treatment doi.org/10.1002/mba2...

#ImmunogenicCellDeath #PDAC #CAR_T #immunotherapy #PancreaticCancer #PhotothermalTherapy #DAMPs

This review explores how #PatternRecognitionReceptors bridge innate and adaptive immunity by sensing #PAMPs and #DAMPs, detailing their signaling, regulation, and therapeutic relevance in #autoimmunity and #cancer. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...

Advances in gasdermin activation, regulation, and targeted drug development - AMM Journal Comprehesive outlook on Gasdermin

An overview on the structure, activation & downstream effects of #gasdermin with implications in various diseases and #targeteddrugdevelopment. #Pyroptosis, #DAMPs #GSDMoligomerization #GSDMDagonists #DrugDelivery

#OpenAccess: amm-journal.org/index.php/20...

Mitochondria have been detected in human blood in a “cell-free” form, but their clinical relevance is unknown. This paper shows elevated levels of mitochondria in the circulation of trauma patients and associations with coagulation. #mitochondria #polytrauma #damps

journals.lww.com/jtr...

Mitochondria have been detected in human blood in a “cell-free” form, but their clinical relevance is unknown. This paper shows elevated levels of mitochondria in the circulation of trauma patients and associations with coagulation. #mitochondria #polytrauma #damps

journals.lww.com/jtr...

Mitochondria have been detected in human blood in a “cell-free” form, but their clinical relevance is unknown. This paper shows elevated levels of mitochondria in the circulation of trauma patients and associations with coagulation. #mitochondria #polytrauma #damps

journals.lww.com/jtr...

2️⃣0️⃣ Possibility 1 - Caspase-11 as a 3D Threat Sensor
Membrane disruptions can expose acyl chains, providing a context-dependent trigger for caspase-11 activation. Caspase-11 may also bind phosphoinositides to guard against bacterial escape. #Immunology #Caspase11 #DAMPs

1️⃣9️⃣ Self-Ligand Detection: Evolutionary Error or Advantage?
Caspase-11’s ability to detect both LPS and self-lipids aligns with Janeway’s PAMP concept. But is self-ligand detection an evolutionary error or an advantage? #Immunology #Caspase11 #DAMPs