Symposia

Is there a gasdermin-shaped hole in your life that needs filling? Join us for the SMART Symposium on #Pyroptosis & #Gasdermin Biology in September! Amazing biology & speakers, organised by the wonderful Vishva Dixit, @v-hornung.bsky.social, Feng Shao & Hao Wu!

symposia.smart.org.cn/sym/event/Fu...

Advances in gasdermin activation, regulation, and targeted drug development - AMM Journal Comprehesive outlook on Gasdermin

An overview on the structure, activation & downstream effects of #gasdermin with implications in various diseases and #targeteddrugdevelopment. #Pyroptosis, #DAMPs #GSDMoligomerization #GSDMDagonists #DrugDelivery

#OpenAccess: amm-journal.org/index.php/20...

Advances in gasdermin activation, regulation, and targeted drug development Proteins of the gasdermin family are executors of pyroptosis.

'Advances in gasdermin activation, regulation, and targeted drug development' - a new @amm-journal.org article on #ScienceOpen:

🔗 www.scienceopen.com/hosted-docum...

🖇️ #Gasdermin #Pyroptosis #ImmunologyResearch #DrugDevelopment

Gasdermin D mutation protects against renal ischemia reperfusion injury Pyroptosis, the most inflammatory form of cell death, is dependent on membrane pore formation governed by the assembly of cleaved Gasdermin D (GSDMD). We hypothesized that regulated necrosis pathways...

#Gasdermin D mutation protects against renal ischemia reperfusion injury #Inflammasome #Pyroptosis

physoc.onlinelibrary.wiley.com/doi/10.14814...

Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells Expanding the consequences of pyroptosis, this study reveals that GSDMD pore-laden pyroptotic EVs transplant GSDMD pores on neighboring cell surfaces and propagate cell death to bystander cells.

This week #JournalClub @labsoap.bsky.social #gasdermin #pyroptosis #extracellularvesicle #DNAPaint @cellpress.bsky.social www.cell.com/cell/abstrac...

Transplantation of #gasdermin pores by extracellular vesicles (EVs) propagates #pyroptosis to bystander cells.

EVs released from pyroptotic cells drive bystander cell death.

www.cell.com/cell/abstrac...

Nice CELLebration during Cytokines 2024 for our new Cell paper!! 👇#EveryCellIsAnImmuneCell! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! authors.elsevier.com/a/1k2OAL7PXqSL5