#GeneticSusceptibility

Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes - Nature Medicine For individuals with APOL1 high-risk genotypes, which are enriched in individuals of African ancestry, a nine-protein proteomic risk score enables early prediction of kidney disease progression and ma...

Nine-protein #APOL1 #ProteomicRiskScore (#APRS) predicting composite outcome of ≥40% #eGFRdecline, #KidneyFailure or death to bridge gap between #GeneticSusceptibility & clinical translation www.nature.com/articles/s41... @ksusztak.bsky.social #TranslationalScience

Pathway-based genetic susceptibility and cleaning agent exposures in adult asthma: A semi explorative G x E analysis in the Personalized Environment and Gene Study (PEGS)
Chen, Y., Chung, M. K.
Paper
Details
#GeneticSusceptibility #EnvironmentalAsthma #PEGSStudy

Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum - Nature Genetics Common-variant and rare-variant association analyses combining datasets from multiple populations yield insights into the genetic architecture of all-cause heart failure across the allele-frequency sp...

105 new loci at #genome-wide significance linked to 5 distinct traits/diseases with shared #GeneticSusceptibility to #HeartFailure doi.org/10.1038/s415... @DavidSMLee @bvoight28.bsky.social @MarylynRitchie @damrauer #TranslationalScience