Laying the groundwork for chrono-mitigatory strategies in the #HospitalEnvironment www.nature.com/articles/s41... @carstenskarke.bsky.social @Nadimeljamal @FitzGerald__Lab #Desynchrony #Chronobiology #CircadianMedicine #TranslationalMedicine

Proteomic risk score for early prediction of kidney disease progression in individuals with APOL1 high-risk genotypes - Nature Medicine For individuals with APOL1 high-risk genotypes, which are enriched in individuals of African ancestry, a nine-protein proteomic risk score enables early prediction of kidney disease progression and ma...

Nine-protein #APOL1 #ProteomicRiskScore (#APRS) predicting composite outcome of ≥40% #eGFRdecline, #KidneyFailure or death to bridge gap between #GeneticSusceptibility & clinical translation www.nature.com/articles/s41... @ksusztak.bsky.social #TranslationalScience

#MicrotubularNetwork largely mediates #CardiacRemodeling of #Cardiomyocytes in response to #MechanicalLoad doi.org/10.1016/j.jm... #MyocardialInfarction #CardiovascularOutcomes #TranslationalScience

The power of immersion to remodel perception of a medical discipline: doi.org/10.5435/JAAO... #OrthopaedicSurgery #MedicalStudent #WorkforceDevelopment #TranslationalScience

HLA-E single-chain trimer shields gene-edited allogeneic CAR T Cells from NK cell attack Key Points. HLA-ESP-1C single chain trimer protects gene-edited (MHC-I/II/TCR/CD54/CD58 deficient) human allogeneic CAR T cells from lysis by NK cells.Univ

Generating universal allogeneic CART (UCART) cells that evade #NKcell “missing-self” response w/ similar performance to autologous #CARTCell in vitro/vivo doi.org/10.1182/bloo... #CellTherapy #ImmunoTherapy #TranslationalScience

A genotype-first framework aimed at defining #CoronaryMicrovascularDisease as an often overlooked and insufficiently treated cause of #IschemicHeartDisease www.ahajournals.org/doi/epdf/10.... @marieguerraty #CMVD #ChestPain #TranslationalScience

TIE2 links MEKK3–KLF2/4 and PI3K signaling in cerebral cavernous malformation Endothelial cell gain of MEKK3–KLF2/4 signaling confers CCM by increasing PI3K signaling. We show that the TIE2 receptor links MEKK3–KLF2/4 and PI3K signal

Extending our understanding of the #MolecularPathogenesis of #CerebralCavernousMalformations doi.org/10.1084/jem.... #CCM disease #DrugTarget #TranslationalScience

CD9 as promising therapeutic target to modulate pathogenic #AdiposeTissue #Macrophages activity while preserving essential homeostatic functions insight.jci.org/articles/vie... @drdavidhill.bsky.social #Obesity #MetabolicDisease #TranslationalScience

Untangling mechanisms underlying #CancerDrugResistance www.nature.com/articles/s41... @jess_ljx @arjunraj.bsky.social #Cancer #DrugResistance #TranslationalScience

Structures of nucleotide-bound Redondovirus Rep protein link conformation and function Author summary We have used cryo-electron microscopy and solution biophysical techniques to understand the structure of the Rep protein from a Redondovirus, a CRESS DNA virus originally found in human...

Characterizing high resolution structures of #Redondovirus Rep proteins doi.org/10.1371/jour... #Virology #InfectiousDisease #TranslationalScience

Leveraging #Polymorphism data as reliable proxy to map mutation patterns across 108 #Eukaryotic species www.pnas.org/doi/10.1073/... @bvoight28 #Methylation #CpG #GxEinteraction #TranslationalScience

Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...

Age-related inhibition of #GutBrainSignaling reduces hippocampal activity and impairs #MemoryEncoding doi.org/10.1038/s415... #Aging #Microbiome #TranslationalScience

Predictive biomarkers of response to chimeric antigen receptor (CAR) T-cell therapy for pan-haematologic cancer - Nature Biomedical Engineering A pan-haematologic cancer approach, involving analysis of data from 256 patients across 5 cancer types and 13 clinical trials, revealed predictive biomarkers for understanding the response or non-resp...

Leveraging #ComputationalBiology at scale to individualize #Immunotherapy: www.nature.com/articles/s41... @JoeFraietta @carlhjune #CARTcelltherapy #CellTherapy #CARTCell #TranslationalScience

Charting a course toward meaningful #AIliteracy in #PediatricCaregiving doi.org/10.1542/peds... #AI #MediaLiteracy #GenerativeArtificialIntelligence #TranslationalScience

Optimizing #CRISPR for #FunctionalGenomics in patient-derived #Xenograft and primary #AcuteMyeloidLeukemia w/ diverse #PathogenicMutations doi.org/10.1016/j.mo... @junwei_s #AML #TranslationalScience

Interbreeding between Neanderthals and modern humans was strongly sex biased Sex biases in admixture and other demographic processes are recurrent features throughout human evolution. For admixture between Neanderthals and anatomically modern humans (AMHs), sex bias has been p...

Novel insight into where the #Neanderthal DNA that persists in people today comes from: www.science.org/doi/10.1126/... @sarahtishkoff.bsky.social #PaleoGenomics #EvolutionaryBiology #TranslationalScience

Reimagining scientific communication using art as a tool for the next generation of translational scientists doi.org/10.1017/cts.... @carstenskarke.bsky.social #ITMATEd #ScienceCommunication #SciComm #SciArt #WorkforceDevelopment #TranslationalScience

#Tryptophan supplementation may attenuate #Naproxen adverse effects and widen its #TherapeuticIndex www.nature.com/articles/s41... @FitzGerald__Lab #Pharmacology #DrugMechanism #DrugSafety #TranslationalScience

Sleep-dependent clearance of brain lipids by peripheral blood cells - Nature Peripheral macrophage-like haemocytes in Drosophila promote sleep by clearing lipid buildup in the brain, helping to maintain metabolic homeostasis and brain function and fitness.

#Drosophila model updates our understanding of brain–periphery interactions: www.nature.com/articles/s41... @amitaseh #BrainHealth #Neurobiology #SleepResearch #Neuroscience #TranslationalScience

Revising the model for #SurfactantProteinC maturation: doi.org/10.1016/j.jb... #PulmonaryFibrosis #CellBiology #ProteinTrafficking #AT2Cells #LungDisease #TranslationalScience

#Epigenetic factor #BRD4: Discerning its role as central regulator of #LungDevelopment with implications to understand its function in adult #LungBiology and disease insight.jci.org/articles/vie... #BromodomainContainingProtein4 #TranslationalScience

#1 in Medical Breakthroughs: Seven of the top 20 papers honored by the Clinical Research Forum (CRF) are from Penn @CRForumUS #TranslationalScience

#NSAID induced #Enteropathy: #Prostaglandin suppression plays only trivial role while enteropathic response to #NSAIDs might be amplified through #Dysbiosis of the #GutMicrobiome www.jci.org/articles/vie... @FitzGerald__Lab #TranslationalScience

Can #BrownAdipose tissue be activated for therapeutic benefit in #MetabolicDisease? Possibly by harnessing cell-autonomous pathways: doi.org/10.1016/j.mo... @BaurLab #TranslationalScience

Social Determinants of Health and Clinical Outcomes in Hypertrophic Cardiomyopathy This cohort study using data from the Sarcomeric Human Cardiomyopathy Registry determines the association of area-based social determinants of health with clinical outcomes in patients with hypertroph...

How your neighborhood modulates genetically determined disease risk jamanetwork.com/journals/jam... #HypertrophicCardiomyopathy #HCM #TranslationalScience

Regulating acetyl-CoA levels through Acetyl-CoA Synthetase 2 emerges as potential safeguard for #CognitiveFunction www.pnas.org/doi/10.1073/... #ACSS2 #Neurodegeneration #Tauopathy #TranslationalScience

Need to consider pharmacokinetic & -dynamic properties & patient-specific risk factors when comparing the cardiovascular risk associated with specific #NSAIDs www.ahajournals.org/doi/epub/10.... @ktheken @TiloGrosser #TranslationalScience

Happy New Year from ITMAT!

Characterizing individual contributions of the different components of #mRNA #vaccine to mount #ImmuneResponse doi.org/10.1016/j.ce... #mRNAvaccine @Loccilab #TranslationalScience