A la Plataforma de Genòmica #IDIBAPS disposem del #GeoMX Digital Spatial Profiler ➡️ permet descriure la heterogeneïtat i complexitat transcriptòmica d’un teixit, a nivell de proteïna o ARN

🧫 Consulta'ns👉IDIGENOM@recerca.clinic.cat

Okayama University Launches J-PEAKS Monthly Digest to Drive Social Change The 19th volume of the J-PEAKS Monthly Digest highlights Okayama University's efforts in social transformation through innovative education and research strategies.

Okayama University Launches J-PEAKS Monthly Digest to Drive Social Change #Japan #GeoMx #Okayama #Okayama_University #J-PEAKS

Sign up to our online #bioinformatics course to:

🔸Gain expert statistical analysis & #R skills
🔸Explore #omic datasets with many experimental groups & #ClinicalData in R
🔸Work on #proteomics, bulk RNA-seq & #GeoMx

Book onto the Feb 2026 course now: https://bit.ly/47kXFaC

#SpatialTranscriptomics #GeoMx @brukerspatial
Human #AbdominalAorticAneurysm
3x Normal
3x CRP-hi AAA
3x CRP-lo AAA

#SmoothMuscleCell NFκB & JNK signals +corr. CRP level

To explore more in raw data?▶️PRJNA1146589 (SRA) ▶️ not found now😅

#FrontImmunol 2024
www.frontiersin.org/journals/imm...

10x Genomics Secures Permanent Injunction Against Bruker Over Patent Infringement Issues 10x Genomics has won a permanent injunction against Bruker Corporation's GeoMx products due to patent infringement. This ruling protects ongoing research while affirming previous jury awards.

10x Genomics Secures Permanent Injunction Against Bruker Over Patent Infringement Issues #United_States #Pleasanton #10x_Genomics #Bruker_Corporation #GeoMx

Molecular Anatomy of Human Ovary
#SpatialTranscriptomics #GeoMx

Surface Cortex Medulla Cyst Vessel Follicles (primary/secondary/antral)

Transcriptional gradient in Ovarian cortex (30 um/layers x 11 layers)
Deeper->⏫NR4A1, CEBPD

#ScienceAdvances 2024
www.science.org/doi/10.1126/...

#SpatialTranscriptomics #GeoMx #ChronicKidneyDisease
#AlportSyndrome
#FocalSegmentalGlomerulosclerosis
#MembranousNephropathy

#Glomeruli vs Tubules

Pathology score
➕corr: Retinoic acid binding
➖corr: Selenocysteine synthesis; SLIT/ROBO

#JCIInsight 2024
insight.jci.org/articles/vie...

Intratumoral heterogeneity & Immune-tumor cell Zonation in #Glioblastoma

Integrative #SpatialTranscriptomics
#GeoMx #CosMx #Xenium +public #Visium

IDH1-WT tumors have more mesenchymal+progenitor-like cells than IDH1-mutant

Neuro-Oncology Advances 2023
academic.oup.com/noa/article/...

#SpatialTranscriptomics #GeoMx @nanostringtech #HypertrophicCardiomyopathy

4 Cases+2 Ctrls, 72 ROIs
1800 transcripts

Focal myocyte disarray showing IFN signaling & mito & ECM perturbations

CD99 signaling b/w cardiomyocytes!?🤪

Michael Chin lab #IJMSMDPI 2023
www.mdpi.com/1422-0067/24...

#Voltron
#SpatialOmics analysis suite
#R

Versatile with multi-resolution methods
#GeoMx #CosMx #Visium #Xenium #SpatialProteomics #ImagingMassSpectrometry

Spatial data-image registration with OpenCV
RCTD/MuSiC for cell-type deconvolution

#bioRxiv 2023
www.biorxiv.org/content/10.1...

Great to see the power of #spatial being used in more comparative analyses (not just descriptive), like this #GeoMx data looking at unique features of CAFs in early onset CRC!