VolitionRx Unveils Groundbreaking Research on Lung Cancer Risk Stratification at ELCC Discover VolitionRx's latest abstract at the European Lung Cancer Conference, showcasing groundbreaking findings in lung cancer risk management.

VolitionRx Unveils Groundbreaking Research on Lung Cancer Risk Stratification at ELCC #USA #Henderson #VolitionRx #H3K27Me3 #nucleosome

Epigenetics Update - Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains bit.ly/3NmLO5Q

Edwina McGlinn and Chen Davidovich (Monash University) reporting in Mol Cell

#Epigenetics #PRC2 #H3K27me3
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Perfect for cancer, immunology, and aging; epigenometech.com

Epigenetics Update - EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming bit.ly/47obbub

#Epigenetic #Chromatin #H3K27me3 #PRC2 #IntergenerationalInheritance

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High-resolution insights without cell sorting; epigenometech.com

Epigenetics Update - Hbo1 and Msl complexes preserve differential compaction and H3K27me3 marking of active and inactive X chromosomes during mitosis go.nature.com/483OnBJ

#Epigenetics #Chromatin #H3K27me3
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Empower your research with high-res epigenetic insights at epigenometech.com

Recent Publication Using Paired-Tag Technology!

“Single-cell profiling of H3K4me1-H3K27me3 revealed bivalent regulation of abnormal neuronal development caused by prenatal e-cigarette vaporing” go.nature.com/461x5CC

#PairedTag #EpigenomeTech #SingleCell #Multiomics #Vaping #H3K4me1 #H3K27me3

Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation Much et al. reveal that the PRC2 subcomplexes PRC2.1 and PRC2.2 play distinct roles in the epigenetic repression of developmental genes in human stem cells. Interactions between the PRC2 core and its ...

Epigenetics Update - Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation bit.ly/4lson6m

Yicheng Long (Weill Cornell Medicine) reporting in Mol Cell

#Epigenetics #PRC2 #H3K27me3
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High-resolution insights without cell sorting; epigenometech.com

CK2 kinase–PRC2 signalling regulates genome-wide H3K27 trimethylation and transduces prolonged cold exposure into epigenetic cold memory in plants - Nature Plants This study reports that the CK2 kinase–H3K27 methyltransferase (PRC2) signalling promotes genome-wide H3K27 trimethylation and the formation of epigenetic cold memory at a potent floral repressor in A...

Epigenetics Update - CK2 kinase–PRC2 signalling regulates genome-wide H3K27 trimethylation and transduces prolonged cold exposure into epigenetic cold memory in plants go.nature.com/40QLm3w

#Epigenetics #H3K27me3 #Plants
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Perfect for cancer, immunology, and aging research; epigenometech.com

Epigenetics Update - Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks go.nature.com/4l9AEN0

#Epigenetics #piRNA #H3K27me3 #H3K9me3
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Perfect for cancer, immunology, and aging research; epigenometech.com

piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation - Nature Structural & Molecular Biology Piwi-interacting RNAs (piRNAs) are vital for genome integrity and fertility. Here the authors reveal that spatial clustering of piRNA genes in Caenorhabditis elegans promotes transcription through pha...

Epigenetics Update - piRNA gene density and SUMOylation organize piRNA transcriptional condensate formation go.nature.com/4n6unDz

Researchers reporting in NSMB

#Epigenetics #piRNA #H3K27me3
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Empower your research with high-res epigenetic insights at epigenometech.com

DEK–nucleosome structure shows DEK modulates H3K27me3 and stem cell fate - Nature Structural & Molecular Biology DEK, a chromatin-associated oncoprotein, regulates chromatin dynamics and cell fate. This study reveals the structural basis of DEK’s interaction with nucleosomes, showing its role in maintaining embr...

Epigenetics Update - DEK–nucleosome structure shows DEK modulates H3K27me3 and stem cell fate go.nature.com/4jbPYHN

#Epigenetics #Chromatin #H3K27me3
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Discover the breakthrough at epigenometech.com

How light and epigenetics cooperate to regulate plant growth A research team led by Prof. Cao Xiaofeng at the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences (CAS) has uncovered the cooperative roles of photoreceptors, ...

How #light and #epigenetics cooperate to regulate #plant #growth.

#gene_expression #H3K27me3 #gene_silencing #Arabidopsis #phyB #hypocotyl #elongation

phys.org/news/2025-03...

Repressed but ready to go: How bivalency holds developmental genes in a poised state for expression As well as being essential in the precise packaging of DNA into the space of the nucleus, histone proteins are also the site of modifications, chemical additions referred to as epigenetic marks, that ...

Repressed but ready to go: How #bivalency holds developmental #genes in a poised state for #expression.

#histones #H3K27me3 #H3K4me3 #Nucleosome #KAT6B

phys.org/news/2025-02...

H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos Nature Cell Biology - Matsuwaka et al. show that JARID2-PRC2 initiates H3K27me2 deposition during the eight-cell-to-morula transition, following H2AK119 mono-ubiquitylation deposition. It is also...

🥂 Congrats to Inoue & co for their new study in our journal (Nature Cell Biology) showing that JARID2-#PRC2 initiates H3K27me2 deposition in the 8-cell-to-morula transition and is also required for subsequent #H3K27me3 deposition at the #blastocyst.
rdcu.be/dZPF5

CD: Switch between #H3K36me3 ⬆️ #H3K27me3 ⬇️ to activate of repress FLC and regulate flowering in response to cold in Arabidopsis. Individual cells are either ON or OFF - quantitative response depends on % of cells in either state resulting in epigenetic memory of cold exposure.