#HepatitisBvirus core protein stability is sustained by host factor PSME1, which prevents HBc degradation via the #26Sproteasome; silencing PSME1 reduces HBc levels & HBV transcription, identifying PSME1 as a novel #biomarker for chronic #HBV.

#OpenAccess: doi.org/10.1016/j.ge...

Virus-Hunter Vaccine Shows Promise in Mice for Chronic HBV Infection | Docwire News In chronic HBV carrier mice, SHARP vaccine variants showed promise toward durable viral control.

A novel innovative virus-hunter #vaccine demonstrated the ability to actively capture viruses and overcome the tolerogenic immune microenvironment that is present with #HepatitisB virus infection.
#HBV #HepatitisBVirus

#Medsk🧪 #IDSky #immunosky #publichealth Although a safe & effective vaccine has been applied to #hepatitisBvirus (HBV) transmission prevention for more than 40 years, chronic HBV infection continues to threaten human health around the world. According to a recent systematic analysis,

🚨BREAKING NEWS🚨

#CDC vaccine advisors have overturned a 34-year-old federal recommendation that says all newborns should be vaccinated against #hepatitisBvirus.

Members who voted against changing the recommendation argued that it will put children at risk.

www.healio.com/news/infecti...

🎤 Our next episode it out!

We chat with Professor Matteo Iannacone ( @iannaconelab.bsky.social ) from @@unisr.bsky.socialabout his work understanding the generation of dysfunctional adaptive immune cells in chronic #HepatitisBVirus infection.

🎧 Listen now: https://bit.ly/4o2W8xa

How many people are infected with the hepatitis B virus?

There are estimated to be more than 210 million infected with this virus on our planet.

#virus #hepatitisb #Hepatitisbvirus #hepatitis

Discovery of VNRX-9945, a Potent, Broadly Active Capsid Assembly Modulator as a Clinical Candidate for the Treatment of Chronic Hepatitis B Virus Infection Targeting the capsid protein of the hepatitis B virus (HBV) has emerged as a promising strategy for developing new antiviral therapies. In this study, we report the discovery of a novel series of pyrrole oxo-carboxamide compounds as HBV capsid assembly modulators (CAMs) that block viral replication. Through a process of focused structure–activity relationship (SAR) optimization, we identified compound 12 (VNRX-9945), which exhibited excellent and broad antiviral activity against multiple HBV genotypes in vitro, along with favorable pharmacokinetic profiles across multiple species. Additionally, 12 demonstrated robust efficacy in the adeno-associated virus mouse model of HBV (AAV-HBV) infection. This compound has advanced into Phase 1 clinical trials to evaluate its safety and pharmacokinetics in healthy volunteers, to enable treatment of chronic HBV infections.

In #ACSMedChemLett Liu et al. report a compound (VNRX-9945) with excellent antiviral activity against multiple #hepatitisBvirus genotypes in vitro, favourable PK profiles across multiple species, and efficacy in a mouse model of disease. pubs.acs.org/doi/10.1021/... #MedicinalChemistry #KellyChibale

Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma

This comprehensive review elucidates the biogenesis of Circular RNAs (#circRNAs) and the pathophysiology of #HepatitisBVirus (HBV)-induced #HepatocellularCarcinoma (HCC) and comprehensively analyzes the applications of circRNAs in oncology and therapeutics. #medsky

#OpenAccess: buff.ly/NdGq4ea

Circular RNAs in hepatitis B virus-induced hepatocellular carcinoma

This comprehensive review elucidates the biogenesis of Circular RNAs (#circRNAs) and the pathophysiology of #HepatitisBVirus (HBV)-induced #HepatocellularCarcinoma (HCC) and comprehensively analyzes the applications of circRNAs in oncology and therapeutics. #medsky

#OpenAccess: buff.ly/9BHjb4Q

To advance global health #equity and #justice, we call for greater #diversity & #inclusion in clinical research, with lesser demographic-based exclusions to ensure clinical evidence applies to all affected populations.
#Bioethics #Equity #Justice #PublicHealth #HepatitisBvirus #Representation

Epigenetic regulation and its therapeutic potential in hepatitis B virus covalently closed circular DNA

This review describes the biology of covalently closed circular DNA (#cccDNA) of #HepatitisBVirus, the mechanisms regulating its transcription, & discusses #antiHBV approaches targeting cccDNA transcription.

#OpenAccess: https://buff.ly/4jqAT6r

Screening great ape museum specimens for DNA viruses - Scientific Reports Scientific Reports - Screening great ape museum specimens for DNA viruses

Screening museum specimens of great apes reveals viral DNA treasures! Researchers identified near-complete genomes, including #hepatitisBvirus strains linked to gorillas & chimpanzees. #VirusGenomics #Museomics #Phylogeny

📄 doi.org/10.1038/s415...
EVBC👤: @scs22.bsky.social

First post on #bluesky !

We’re a patient advocacy group and soon to be charity looking to support people living with #HepatitisBVirus and their families

Www.hepbcompanion.org

Crocheted model of the Hepatitis B virus showing the #virus structure

#crochet #sciart #hepatitis #worldhepatitisday #hepatitisbvirus #microbiology #virology #science

New virus has been added to my crocheted #hepatitis virus collection (Hepatitis D virus).

Swipe left to check the entire collection

#worldhepatitisday
#hepatitisbvirus #hepatitisday #crochet #sciart #science #microbiology #infectiousdisease