Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion Plitt and Kaganovsky et al. examine how postsynaptic membrane fusion controls hippocampal computations during behavior. By performing in vivo calcium imaging after deleting Syntaxin3 in CA1, they show...

#Hippocampal place #code #plasticity in #CA1 requires #postsynaptic membrane fusion: Neuron www.cell.com/neuron/fullt...

☃️Fabulous February: Image of the Month

Super-resolution image of a primary #hippocampal neuronal culture🧠. Seeded in a µ-Slide 18 Well Glass Bottom and imaged on a @zeiss-microscopy.bsky.social

🥼Scientific #artwork by Alexandra Tsitrina from @bengurionuniv.bsky.social , Beersheba, Israel

#sciart

Circular RNA circHomer1 mediates hippocampal functions via ribonucleoprotein granule transport and dendritic targeting of synaptic RNAs Circular RNA circHomer1 mediates the dendritic targeting of mRNAs to shape dendritic spines and hence neuronal functions.

Circular #RNA circHomer1 mediates #hippocampal functions via ribonucleoprotein granule transport and #dendritic targeting of #synaptic RNAs | Science Advances www.science.org/doi/10.1126/...

Hippocampal estrogen levels, receptor types, and epigenetics contribute to sex-specific memory vulnerabilities to concurrent acute stresses Acute concurrent stresses provoke lasting, sex-dependent memory problems. Hokenson, Rodríguez-Acevedo, et al. find that high hippocampal estrogen levels in mice generate permissive chromatin states, a...

#Hippocampal #estrogen levels, receptor types, and #epigenetics contribute to #sex-specific #memory vulnerabilities to concurrent acute #stresses: Neuron www.cell.com/neuron/fullt...

#Hippocampal delivery of SynCav1 at symptomatic stages in #AlzheimersDisease mouse models preserves memory, restores #synaptic signaling, downregulates #neurodegeneration pathways, and upregulates #CognitivePathways. @uofcalifornia.bsky.social

#STTT: doi.org/10.1038/s413...

The findings highlight #WASO and #LPA, as measured by #wearable devices, as modifiable #behavioral factors linked to #memory function in older adults. The impact of these factors intensifies with advancing age & may be influenced by #hippocampal reserve.

Slitrk1 and Slitrk2 proteins are widely expressed in various layers of hippocampal CA1 and DG but exhibit distinct enriched expression patterns. (A) Schematic of immunohistochemical analysis strategy used to analyze the protein expression patterns of Slitrk1 and Slitrk2 in the hippocampal subfields of adult mice. Representative images showing Slitrk1 protein distribution in coronal brain sections from adult male mice. Scale bar, 100 µm (applies to all images). (B–I) Representative images (B, F for Slitrk1 and C, G for Slitrk2) and quantification of mean intensity distributions for Slitrk1 (D, H) and Slitrk2 (E, I) across CA1 and DG layers. Data are presented as means ± SEMs (n = 6 mice/group). Scale bars, 50 µm (applies to all images). Abbreviations: SO, stratum oriens; SR, stratum radiatum; SP, stratum pyramidale; SLM, stratum lacunosum-moleculare; GCL, granule cell layer; ML, molecular layer.

Slitrk1 & Slitrk2 are structurally & biochemically similar, so what role do they each play in #synapses? This study shows that each acts in distinct #hippocampal subfields & via different binding partners. Relevance to Slitrk2's association with #schizophrenia @plosbiology.org 🧪 plos.io/4qibtuo

Slitrk1 and Slitrk2 proteins are widely expressed in various layers of hippocampal CA1 and DG but exhibit distinct enriched expression patterns. (A) Schematic of immunohistochemical analysis strategy used to analyze the protein expression patterns of Slitrk1 and Slitrk2 in the hippocampal subfields of adult mice. Representative images showing Slitrk1 protein distribution in coronal brain sections from adult male mice. Scale bar, 100 µm (applies to all images). (B–I) Representative images (B, F for Slitrk1 and C, G for Slitrk2) and quantification of mean intensity distributions for Slitrk1 (D, H) and Slitrk2 (E, I) across CA1 and DG layers. Data are presented as means ± SEMs (n = 6 mice/group). Scale bars, 50 µm (applies to all images). Abbreviations: SO, stratum oriens; SR, stratum radiatum; SP, stratum pyramidale; SLM, stratum lacunosum-moleculare; GCL, granule cell layer; ML, molecular layer.

Slitrk1 & Slitrk2 are structurally & biochemically similar, so what role do they each play in #synapses? This study shows that each acts in distinct #hippocampal subfields & via different binding partners. Relevance to Slitrk2's association with #schizophrenia @plosbiology.org 🧪 plos.io/4qibtuo

Slitrk1 and Slitrk2 proteins are widely expressed in various layers of hippocampal CA1 and DG but exhibit distinct enriched expression patterns. (A) Schematic of immunohistochemical analysis strategy used to analyze the protein expression patterns of Slitrk1 and Slitrk2 in the hippocampal subfields of adult mice. Representative images showing Slitrk1 protein distribution in coronal brain sections from adult male mice. Scale bar, 100 µm (applies to all images). (B–I) Representative images (B, F for Slitrk1 and C, G for Slitrk2) and quantification of mean intensity distributions for Slitrk1 (D, H) and Slitrk2 (E, I) across CA1 and DG layers. Data are presented as means ± SEMs (n = 6 mice/group). Scale bars, 50 µm (applies to all images). Abbreviations: SO, stratum oriens; SR, stratum radiatum; SP, stratum pyramidale; SLM, stratum lacunosum-moleculare; GCL, granule cell layer; ML, molecular layer.

Slitrk1 & Slitrk2 are structurally & biochemically similar, so what role do they each play in #synapses? This study shows that each acts in distinct #hippocampal subfields & via different binding partners. Relevance to Slitrk2's association with #schizophrenia @plosbiology.org 🧪 plos.io/4qibtuo

Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show, in mi...

#Cortical glutamatergic and GABAergic inputs support #learning -driven #hippocampal stability | Science www.science.org/doi/10.1126/...

In a recent study, Hao Xing et al. observed enhancement of #hippocampal interneuron excitability by #NMDA receptor positive allosteric modulation 🧠 🔬

📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...

😱What if a *spinal tap* could predict #Brain shrinkage? 🧠💉 #ML pinpoints #Alzheimer’s patients at *high risk* of #Hippocampal loss! 📉 @mdpiopenaccess.bsky.social #Alzheimers #AI #Neuroscience 🔗👇
www.mdpi.com/2227-9059/13...

💡First-ever #ML model using #CSF blood load to forecast #Hippocampal decay🧠💧 Ridge AUC = 1.00 = *perfection*!🎯🔥 @mdpiopenaccess.bsky.social #Biomedicines #AIinMedicine #Innovation👇
www.mdpi.com/2227-9059/13...

😱What if a *spinal tap* could predict #Brain shrinkage? 🧠💉 #ML pinpoints #Alzheimer’s patients at *high risk* of #Hippocampal loss! 📉 @mdpiopenaccess.bsky.social #Alzheimers #AI #Neuroscience 🔗👇
www.mdpi.com/2227-9059/13...

Join us TODAY at 3 pm US Pacific time for "Connectomic traces of Hebbian plasticity in the entorhinal-hippocampal system" at carboncopies.org/aspirational... #memorydecoding #aspirationalneuroscience #hippocampal #plasticity #connectome

Patterns of c-Fos expression in the SC, PAG, and HPC reveal a loss of activity in the SC and PAG following extinction-updating but persistent activity of the vCA1. Top left: Engram labeling strategy. Bottom: TRAP2xAi32 mice underwent one of three types of behavioral paradigms; re-exposure (n = 6 mice) vs. no re-exposure (n = 6 mice), extinction (n = 7 mice) vs. innate (n = 8 mice), or updating (n = 11 mice) vs. innate (n = 8 mice). Mice were injected with 4-OHT to transiently induce c-Fos dependent EYFP upon first exposure to the looming stimulus, and later perfused 60 min following stimulus presentation at the end of the behavioral paradigm. Tolp right: Example histology from the SC, with an EYFP+c-Fos+ cell highlighted by the white arrow.

How do we balance innate responses & adaptive learning when reacting to threats? @tjryan.bsky.social &co show that repeated exposure to looming stimuli reduces innate defensive responses via #hippocampal modulation, revealing a vCA1 engram needed for learned #fear @plosbiology.org 🧪 plos.io/4pNSnNp

Patterns of c-Fos expression in the SC, PAG, and HPC reveal a loss of activity in the SC and PAG following extinction-updating but persistent activity of the vCA1. Top left: Engram labeling strategy. Bottom: TRAP2xAi32 mice underwent one of three types of behavioral paradigms; re-exposure (n = 6 mice) vs. no re-exposure (n = 6 mice), extinction (n = 7 mice) vs. innate (n = 8 mice), or updating (n = 11 mice) vs. innate (n = 8 mice). Mice were injected with 4-OHT to transiently induce c-Fos dependent EYFP upon first exposure to the looming stimulus, and later perfused 60 min following stimulus presentation at the end of the behavioral paradigm. Tolp right: Example histology from the SC, with an EYFP+c-Fos+ cell highlighted by the white arrow.

How do we balance innate responses & adaptive learning when reacting to threats? @tjryan.bsky.social &co show that repeated exposure to looming stimuli reduces innate defensive responses via #hippocampal modulation, revealing a vCA1 engram needed for learned #fear @plosbiology.org 🧪 plos.io/4pNSnNp

Patterns of c-Fos expression in the SC, PAG, and HPC reveal a loss of activity in the SC and PAG following extinction-updating but persistent activity of the vCA1. Top left: Engram labeling strategy. Bottom: TRAP2xAi32 mice underwent one of three types of behavioral paradigms; re-exposure (n = 6 mice) vs. no re-exposure (n = 6 mice), extinction (n = 7 mice) vs. innate (n = 8 mice), or updating (n = 11 mice) vs. innate (n = 8 mice). Mice were injected with 4-OHT to transiently induce c-Fos dependent EYFP upon first exposure to the looming stimulus, and later perfused 60 min following stimulus presentation at the end of the behavioral paradigm. Tolp right: Example histology from the SC, with an EYFP+c-Fos+ cell highlighted by the white arrow.

How do we balance innate responses & adaptive learning when reacting to threats? @tjryan.bsky.social &co show that repeated exposure to looming stimuli reduces innate defensive responses via #hippocampal modulation, revealing a vCA1 engram needed for learned #fear @plosbiology.org 🧪 plos.io/4pNSnNp

🫆 Assessment of #Brain Structure Volumes in Children with Multiple #Sclerosis — a Potential Marker of Radiological Diagnostic Criteria

🧠 There is significant reductions in #thalamic and increases in #hippocampal volumes in children with multiple sclerosis

📖 More: mspsss.org.ua/index.php/jo...

Cooperative actions of interneuron families support the hippocampal spatial code Identifying the computational roles of different neuron families is crucial for understanding neural networks. Most neural diversity is embodied in various types of γ-aminobutyric acid–mediated (GABAe...

Cooperative actions of #interneuron families support the #hippocampal spatial #code
www.science.org/doi/10.1126/...

Feeling just 'meh' about life? It could be anhedonia – here's how to reverse it | BBC Science Focus Magazine When everything feels... well, 'meh', there's complex chemistry at play in your brain. Experts explain the science of 'anhedonia' – and how to get the colour back in your life.

In anhedonia-susceptible mice, brain signals failed to distinguish between sugar and plain water. According to researchers, this indecision resembled symptoms of #depression in humans. Using chemogenetics, they reversed this effect by activating specific #hippocampal cells.

Kisang Eom et al. investigated input-specific bidirectional regulation of #hippocampal CA3 pyramidal cell excitability 🧠 🔍

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Enjoying reading Nachum Ulyanovsky’s book #NaturalNeuroscience 🤓

[[ So excited see our work on the synchronisation between #steps and #hippocampal representations featured here 🤩

How cognitive processes interact with actions is the goal we are working towards. Natural behavior is necessary 🙌🏽 ]]

🧠 Connections between Hippocampal Neurons

Confocal microscopy image of neurons cultured from hippocampi of newly born mice at 63x magnification (by Igor Korolev, DO, PhD)

(IMAGE CREDIT: Jason Kirk, Quynh Nguyen; Baylor College of Medicine)
#neurons #Hippocampal #neuroscience

Maggie P. Rempe of boystown-ihn.bsky.social‬ & unmc.bsky.social‬ et al. observed that #hippocampal and cortical oscillatory dynamics reflect semantic processing and predict #behavioural performance 🧠 ⚙️

📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/JP287373

Thanks @fof.se for highlighting our research! 🙌 Using 7T MRI, Tobias Navarro-Schroeder (@kavlintnu.bsky.social) & I study #TransientGlobalAmnesia as a model for reversible #hippocampal inactivation & #memoryloss across disorders. #Transdiagnostic approach is 🔑 to study circuit-symptom relationships!

These #Tregs appear to restrain #IFN gamma production & #inflammation (by regulating #IL-2 levels), inhibit immunocyte infiltration into the #parenchyma, restrain #glial cells in #hippocampus, regulate #hippocampal #neurogenesis, & promote short-term #memory!

"These results also highlight that #cognitive impairments observed in aging may be due to impaired insulin signaling" #NPY

Title: The effect of insulin receptor deletion in neuropeptide Y neurons on #hippocampal dependent cognitive function in #aging mice...

Reset of hippocampal–prefrontal circuitry facilitates lea... Exposure to a novel experience can ‘reset’ connections be...

"Reset of #hippocampal–prefrontal circuitry facilitates #learning" Newest in @nature from @APNeuro and team
https://www.nature.com/articles/s41586-021-03272-1

Mapping the epigenomic and transcriptomic interplay durin... The authors show that a coordinated epigenetic priming ev...

Ever wonder how memories are made? "Mapping the #epigenomic and transcriptomic interplay during memory formation and recall in the #hippocampal engram ensemble" https://www.nature.com/articles/s41593-020-00717-0