BirchBioMed Gains Health Canada Approval for Scar Treatment Cream to Address Severe Scars BirchBioMed Inc. has achieved regulatory approval for its FS2 (KynA) topical cream by Health Canada, promising to improve scar treatment capabilities. This innovative product targets even the most severe scars.

BirchBioMed Gains Health Canada Approval for Scar Treatment Cream to Address Severe Scars #Canada #Vancouver #BirchBioMed #Scar_Treatment #KynA

🚨 BREAKTHROUGH: #KYNA protects #Neurons but cripples movement! Our analogs🧪decouple #Therapy from #Toxicity ✨ SZR-73 keeps motor skills intact while boosting #Brain #Health!🧠 @mdpiopenaccess.bsky.social #NeuroScience #Pharma #MentalHealthMatters
Read & share! www.mdpi.com/2073-4409/14...

⚡ #KYNA helps the #Brain but causes #Ataxia 😵We designed safer #Analogs 👉SZR-72, -73, -81 Results? No motor toxicity+therapeutic promise!🌟 @mdpiopenaccess.bsky.social #Parkinsons #Schizophrenia #Neuroprotection #FutureMedicine #Research
Read & share! www.mdpi.com/2073-4409/14...

🚨🧪No behavioral change—but the brain’s metabolic circuits exploded!💣 #KYNA ↓ in #Cortex 🧠, ↑ in #Striatum 🎯— #Trp chaos exposed!⚡ @mdpiopenaccess.bsky.social #Neuroscience #Metabolomics #KynureninePathway #Trp
📖 www.mdpi.com/2073-4409/14...

The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration Kynurenine pathway enzyme knockouts impair mitochondrial respiration. The deletion of kynurenine aminotransferase genes leads to significant impairment of mitochondrial respiration and ATP production....

🔬✨Surprise! #KYNA isn’t just a neuroprotector!🛡️—it’s a lifeline for #ATP production!🔋🧠KAT knockouts=failing #Mitochondrial respiration⚡💔
#Discovery #Mitochondria #Neurobiology
doi.org/10.1111/jnc....

🧠1 BILLION people suffer #Neuropsychiatric disorders! Our study shows #KYNA analogs⛑️protect the #Brain WITHOUT motor side effects🚶‍♂️💡SZR-73 leads the way! @mdpiopenaccess.bsky.social #NeuroScience #BrainHealth #Innovation #DrugDiscovery #MentalHealth
Read & share! www.mdpi.com/2073-4409/14...

🧠 #KYNA causes #Ataxia fast—SZR-73?
💥Clean motor profile, delayed action—real #Promise! @mdpiopenaccess.bsky.social #NeuroTwitter #DrugDiscovery #TranslationalResearch
💊Read + RT🔁 www.mdpi.com/2073-4409/14...

🚨🧪No behavioral change—but the brain’s metabolic circuits exploded!💣 #KYNA ↓ in #Cortex 🧠, ↑ in #Striatum 🎯— #Trp chaos exposed!⚡ @mdpiopenaccess.bsky.social #Neuroscience #Metabolomics #KynureninePathway #Trp
📖 doi.org/10.20944/pre...

💥 #Neuro disorders hit 1B+ lives worldwide! #KYNA analogs offer new hope 🧠—protecting glutamatergic pathways✨without motor side effects! 🎯 SZR-73 shines as a lead candidate🌟 @mdpiopenaccess.bsky.social #NeuroInnovation #DrugDiscovery #MentalHealth
Read & share! www.mdpi.com/2073-4409/14...

😲 #KYNA saves #Neurons but induces #Ataxia fast (15 min!)⏱️Good news: new analogs (esp. SZR-73) show #Brain benefits WITHOUT impairing movement! 🚶‍♀️🙌 @mdpiopenaccess.bsky.social #DrugDiscovery #Neuropsychiatry #ClinicalTranslation #Innovation #BrainHealth
Read & share! www.mdpi.com/2073-4409/14...

The Power Struggle: Kynurenine Pathway Enzyme Knockouts and Brain Mitochondrial Respiration Kynurenine pathway enzyme knockouts impair mitochondrial respiration. The deletion of kynurenine aminotransferase genes leads to significant impairment of mitochondrial respiration and ATP production....

🔬✨Surprise! #KYNA isn’t just a neuroprotector!🛡️—it’s a lifeline for #ATP production!🔋🧠KAT knockouts=failing #Mitochondrial respiration⚡💔 #Discovery #Mitochondria #Neurobiology
doi.org/10.1111/jnc....

🚨 BREAKTHROUGH: #KYNA protects #Neurons but cripples movement! Our analogs🧪decouple #Therapy from #Toxicity ✨ SZR-73 keeps motor skills intact while boosting #Brain #Health!🧠 @mdpiopenaccess.bsky.social #NeuroScience #BrainResearch #Pharma
Read & share! www.mdpi.com/2073-4409/14...

⚡ #KYNA helps the #Brain but causes #Ataxia 😵We designed safer #Analogs 👉SZR-72, -73, -81 Results? No motor toxicity+therapeutic promise!🌟 @mdpiopenaccess.bsky.social #Parkinsons #Schizophrenia #Neuroprotection #FutureMedicine #Research
Read & share! www.mdpi.com/2073-4409/14...

🧠1 BILLION people suffer #Neuropsychiatric disorders! Our study shows #KYNA analogs⛑️protect the #Brain WITHOUT motor side effects🚶‍♂️💡SZR-73 leads the way! @mdpiopenaccess.bsky.social #NeuroScience #BrainHealth #Innovation #DrugDiscovery #MentalHealth
Read & share! www.mdpi.com/2073-4409/14...

Ever wondered if deleting a single gene could spark #PTSD-like #Despair?🧠💔In #CRISPR mice we see despair-unique #Depression🐀⬇️ low #KYNA & high #Oxidative/excitotoxic #Stress⚗️🔥@istry_media #PTSD #Neuroscience #MentalHealth #Kynurenine
Dive in & share!
doi.org/10.31083/FBL...

Could tweaking #KYNA unlock safer #Schizophrenia & #Parkinson’s treatments?🤔🧠 SZR-73 preserves motor skills🏃‍♂️👍&shows therapeutic promise💥🔬 @mdpiopenaccess.bsky.social #Neuropharma #KYNA #DrugDiscovery
Read & share! www.mdpi.com/2073-4409/14...

🚨 #KYNA analog SZR‑73: no ataxia, keeps your #Motor skills intact!🏃‍♂️⚡️KYNA analogs uncouple #Neuroprotection from motor toxicity in #Schizophrenia & #Parkinson’s models; SZR‑73 preserves #Coordination & #Neuromodulation🤯💊🔬🌟 @mdpiopenaccess.bsky.social
👉 Dive in now! www.mdpi.com/2073-4409/14...

Ever wondered if deleting a single gene could spark #PTSD-like #Despair?🧠💔In #CRISPR mice we see despair-unique #Depression🐀⬇️ low #KYNA & high #Oxidative/excitotoxic #Stress⚗️🔥@istry_media #PTSD #Neuroscience #MentalHealth #Kynurenine
Dive in & share!
doi.org/10.31083/FBL...

Decoupling Behavioral Domains via Kynurenic Acid Analog Optimization: Implications for Schizophrenia and Parkinson’s Disease Therapeutics Kynurenic acid (KYNA), a putative neuroprotective agent, modulates glutamatergic pathways in schizophrenia and Parkinson’s disease but is limited by acute motor activity impairments (e.g., ataxia). Research leveraging animal disease models explores its structure–activity relationship to enhance therapeutic efficacy while mitigating adverse effects, addressing global neuropsychiatric disorders affecting over 1 billion people. Structural analogs of KYNA (SZR-72, SZR-73, and SZR-81) were designed to uncouple therapeutic benefits from motor toxicity; yet, systematic comparisons of their acute behavioral profiles remain unexplored. Here, we assess the motor safety, time-dependent effects, and therapeutic potential of these analogs in mice. Using acute intracerebroventricular dosing, we evaluated motor coordination (rotarod), locomotor activity (open-field), and stereotypic behaviors. KYNA induced significant ataxia and stereotypic behaviors at 15 min, resolving by 45 min. In contrast, all analogs avoided acute motor deficits, with SZR-73 maintaining baseline rotarod performance and eliciting a delayed decrease in ambulation and inquisitiveness in open-field assays. These findings demonstrate that the structural optimization of KYNA successfully mitigates motor toxicity while retaining neuromodulatory activity. Here, we show that SZR-73 emerges as a lead candidate, combining transient therapeutic effects with preserved motor coordination. This study advances the development of safer neuroactive compounds, bridging a critical gap between preclinical innovation and clinical translation. Future work must validate chronic efficacy, disease relevance, and mechanistic targets to harness the full potential of KYNA analogs in treating complex neuropsychiatric disorders.

🚨 #KYNA analog SZR‑73: no ataxia, keeps your #Motor skills intact!🏃‍♂️⚡️KYNA analogs uncouple #Neuroprotection from motor toxicity in #Schizophrenia & #Parkinson’s models; SZR‑73 preserves #Coordination & #Neuromodulation🤯💊🔬🌟 @mdpiopenaccess.bsky.social
👉 Dive in now! www.mdpi.com/2073-4409/14...

🤔Can we reengineer a #Neuroprotective molecule to treat #Schizophrenia without stumbling?
🧠 #KYNA causes #Ataxia fast—SZR-73?
💥Clean motor profile, delayed action—real #Promise! @mdpiopenaccess.bsky.social #NeuroTwitter #DrugDiscovery #TranslationalResearch
💊Read + RT🔁 www.mdpi.com/2073-4409/14...

Ever wondered if deleting a single gene could spark #PTSD-like #Despair?🧠💔In #CRISPR mice we see despair-unique #Depression🐀⬇️ low #KYNA & high #Oxidative/excitotoxic #Stress⚗️🔥@istry_media
#PTSD #Neuroscience #MentalHealth #Kynurenine
Dive in & share!
doi.org/10.31083/FBL...

🤔Can we reengineer a #Neuroprotective molecule to treat #Schizophrenia without stumbling?
🧠 #KYNA causes #Ataxia fast—SZR-73?
💥Clean motor profile, delayed action—real #Promise! @mdpiopenaccess.bsky.social #NeuroTwitter #DrugDiscovery #TranslationalResearch
💊Read + RT🔁 www.mdpi.com/2073-4409/14...

🤔Can we reengineer a #Neuroprotective molecule to treat #Schizophrenia without stumbling?
🧠 #KYNA causes #Ataxia fast—SZR-73?
💥Clean motor profile, delayed action—real #Promise! @MDPIOpenAccess @Cells_MDPI #NeuroTwitter #DrugDiscovery #TranslationalResearch
💊Read + RT🔁 www.mdpi.com/2073-4409/14...

Ever wondered if deleting a single gene could spark #PTSD-like #Despair?🧠💔In #CRISPR mice we see despair-unique #Depression🐀⬇️ low #KYNA & high #Oxidative/excitotoxic #Stress⚗️🔥@istry_media #PTSD #Neuroscience #MentalHealth
Dive in & share!
doi.org/10.31083/FBL...

#KYNA helps the brain but causes #Ataxia 😵‍💫We made SZR-73: keeps the #Neuroprotection, ditches the #Motor side effects🧠🦾First real shot at safer drugs for #Schizophrenia & ##Parkinsons!🔥 @mdpiopenaccess.bsky.social #NeuroScience #DrugDiscovery 🧬🧪⚡🤯💥
👉 www.mdpi.com/2073-4409/14...

#KYNA helps the brain but causes #Ataxia 😵‍💫We made SZR-73: keeps the #Neuroprotection, ditches the #Motor side effects🧠🦾First real shot at safer drugs for #SCZ & #PD!🔥 @MDPIOpenAccess @Cells_MDPI #NeuroScience #Parkinsons #Schizophrenia #DrugDiscovery #KYNA 🧬🧪⚡🤯💥👉 www.mdpi.com/2073-4409/14...

#KYNA helps the brain but causes #Ataxia 😵‍💫We made SZR-73: keeps the #Neuroprotection, ditches the #Motor side effects🧠🦾First real shot at safer drugs for #SCZ & #PD!🔥 @mdpiopenaccess.bsky.social #NeuroScience #Parkinsons #Schizophrenia #DrugDiscovery #KYNA 🧬🧪⚡🤯💥👉 www.mdpi.com/2073-4409/14...

#KYNA helps the brain but causes #Ataxia 😵‍💫We made SZR-73: keeps the #Neuroprotection, ditches the #Motor side effects🧠🦾First real shot at safer drugs for #SCZ & #PD!🔥 @mdpiopenaccess.bsky.social #NeuroScience #Parkinsons #Schizophrenia #DrugDiscovery #KYNA 🧬🧪⚡🤯💥👉 www.mdpi.com/2073-4409/14...

🐭💊Mice on #KYNA= #Brain boost 🧠but drunk walk🚶‍♂️💥So we tweaked it…🔥SZR-73=same neuroprotection ZERO motor mess! No #Ataxia No chaos Just clean brain work🧪⚡ RT if you’re into smarter drugs👉 @mdpiopenaccess.bsky.social #Neuroscience #KYNA #Parkinsons #DrugDiscovery
doi.org/10.20944/pre...

🐭💊Mice on #KYNA= #Brain boost 🧠but drunk walk🚶‍♂️💥So we tweaked it…🔥SZR-73=same neuroprotection ZERO motor mess! No #Ataxia No chaos Just clean brain work🧪⚡ RT if you’re into smarter drugs👉 @mdpiopenaccess.bsky.social #Neuroscience #KYNA #Parkinsons #DrugDiscovery
doi.org/10.20944/pre...