Potent neutralization by antibodies targeting the MPXV A28 protein - Nature Communications Recent MPXV outbreaks underscore the need for better vaccines and treatments. Here, the authors isolate and structurally characterize potent antibodies interacting with A28 that they identify as a key viral surface protein essential for viral entry and that induces strong, protective antibody response in mice.

#Virology

Potent neutralization of the #Mpox virus by monoclonal antibodies targeting the viral A28 protein

#MPXV #antibodies

Potent neutralization by antibodies targeting the MPXV A28 protein - Nature Communications Recent MPXV outbreaks underscore the need for better vaccines and treatments. Here, the authors isolate and structurally characterize potent antibodies interacting with A28 that they identify as a key viral surface protein essential for viral entry and that induces strong, protective antibody response in mice.

#Virology

Potent neutralization of the #Mpox virus by monoclonal antibodies targeting the viral A28 protein

#MPXV #antibodies

Eurosurveillance | First detection and autochthonous transmission of monkeypox virus clade Ib in the Netherlands, October to November, 2025 In October–November 2025, eight autochthonous cases of monkeypox (MPXV) clade Ib virus infection were reported in the Netherlands. All cases were men who have sex with men aged 25–65; none required hospital admission or antiviral treatment. Phylogenetic analysis combined with contact tracing suggest multiple introductions or cryptic circulation with onwards transmission within the community. Highly related international sequences were identified dating back to August 2025, indicating sustained global community transmission of clade Ib outside the African continent.

Indicating ongoing local transmission: between Oct-Nov 2025, 8 people were diagnosed with #mpox caused by infection with monkeypox virus (MPXV) clade Ib in the Netherlands - with now multiple #MPXV clades co-circulating in #Europe

#IDsky #EpiSky #MedSky #MicroSky #STISky 🛟🧪 @flahless.bsky.social

Eurosurveillance table of content issue 3 in 2026 Editorial World Leprosy Day 2026: reflections on leprosy surveillance in Europe Rapid communication First detection and autochthonous transmission of monkeypox virus clade Ib in the Netherlands, October to November, 2025 Outbreaks First use of Trumenba (MenB-fHbp) vaccine to control a nursery outbreak of serogroup B invasive meningococcal disease involving children previously immunised with Bexsero (4CMenB), England, November 2023 Surveillance Epidemiology of human salmonellosis in Czechia ─ a country with the highest European notification rate, 2012 to 2023 Perspective Integrating AMR surveillance into wastewater monitoring systems in 2025: a position on the implementation of Article 17 of the Urban Wastewater Treatment Directive (UWWTD)

In our new issue, @flahless.bsky.social and colleagues describe clinical presentation, transmission dynamics, #PublicHealth response & phylogenetic analysis of the first local transmission of #MPXV clade Ib virus in the Netherlands

🗞️ bit.ly/EUS313

#EpiSky #IDSky #MedSky #MicroSky 🛟🧪 #mpox #AMR

WHO DON: Broader Transmission of Mpox Due to clade Ib MPXV – Global situation #18,975 Although the 2nd declaration of a public health emergency of international concern (PHEIC ) for mpox was lifted 3 months ago , sin...

AFD Blog `WHO DON: Broader Transmission of #Mpox Due to clade Ib #MPXV – Global situation' afludiary.blogspot.com/2025/12/who-...

Broader transmission of mpox due to clade Ib MPXV – Global situation The purpose of this report is to raise awareness about the local transmission of clade Ib monkeypox virus (MPXV) among men who have sex with men (MSM) in countries previously unaffected or to date rep...

Broader transmission of mpox due to clade Ib #MPXV – Global situation.
#monkeypox
www.who.int/emergencies/...

Broader #transmission of #mpox due to clade Ib #MPXV – #Global #situation (#WHO D.O.N., Dec. 5 '25, summary)

Broader #transmission of #mpox due to clade Ib #MPXV – #Global #situation (#WHO D.O.N., Dec. 5 '25, summary), etidiohnew.blogspot.com/2025/12/broa...

Impaired Cellular Immunity and Cross‐Reactive Humoral Responses to Mpox Virus in HIV‐Infected Individuals Vaccinated with Vaccinia Virus Tiantan Strain This study examines MPXV immunity in PLWH, focusing on smallpox vaccine-induced responses. PLWH with CD4⁺ T-cell counts <500 cells/mm3 showed reduced VTT-IgG, MPXV-IgG, and NAbs, while CD4⁺ T-cell re....

#Article in #MedComm
Impaired Cellular Immunity and Cross-Reactive Humoral Responses to Mpox Virus in HIV-Infected Individuals Vaccinated with Vaccinia Virus Tiantan Strain doi.org/10.1002/mco2...

#HIV #MPXV #HumoralImmuneResponses #MemoryTcell #VacciniaVirus #PLWH

Searching for Mpox on surfaces and in the air Between October 2024 and January 2025, the UK identified eight cases of Clade Ib Monkeypox virus (MPXV), with seven patients admitted to high consequence infectious disease (HCID) centres. A compre…

Here's a new blog post aboutsurface/air contamination with #MPXV in the rooms of patients with #Mpox reflectionsipc.com/2025/10/09/s... @eurosurveillance.org

This study reports ODE-(S)-HPMPA formate as a potent anti-orthopoxvirus candidate, showing over 40-fold greater activity against #MPXV than #brincidofovir (BCV), & promising protection when combined with BCV. @fudan-university.bsky.social

#STTT #OpenAccess: doi.org/10.1038/s413...

New research article

Genomic epidemiology of clade Ia #monkeypox viruses circulating in the Central African Republic in 2022–24: a retrospective cross-sectional study

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #ViroSky #mpox #mpxv #OpenAccess #OA

Can the monkeypox virus infect the human brain? A new study led by researchers from the Institute of Virology and Immunology (IVI) and the University of Bern in collaboration with the Lausanne University Hospital and the Spiez Federal Laboratory sh...

New study shows that the monkeypox virus (MPXV) can infect neuronal cells in brain organoids and cause their death: mediarelations.unibe.ch/media_releas....
This previously unexplored aspect of #MPXV was discovered by a research team from the #IVI, #unibern, #CHUV and the #BundeslaborSpiez.

Kann das Affenpockenvirus das menschliche Gehirn infizieren? Eine neue Studie unter der Leitung von Forschenden des Instituts für Virologie und Immunologie (IVI) und der Universität Bern in Zusammenarbeit mit dem Centre hospitalier universitaire vaudois (CHUV) ...

Neue Studie zeigt: Das Affenpockenvirus (MPXV) kann neuronale Zellen in Hirnorganoiden infizieren und deren Tod verursachen: mediarelations.unibe.ch/medienmittei....

Diese bisher unerforschten Aspekte von #MPXV hat ein Forschungsteam des #IVI, #unibern, #CHUV und des #Bundeslabor Spiez entdeckt.

Image showing the table of content of issue 19 in 2025: Rapid communication Air and surface sampling for clade Ib monkeypox virus in United Kingdom hospitals, 2024 to 2025 Research Human infections with Eurasian avian-like swine influenza virus detected by coincidence via routine respiratory surveillance systems, the Netherlands, 2020 to 2023 Review Frameworks to support evidence-informed decision-making in public health and infectious disease prevention and control: a scoping review Users’ experience of frameworks to support evidence-informed decision-making in public health: a scoping review

Check out our new issue 🗞️ bit.ly/EUS3019

Findings from the rapid communication by Atkinson et al. underscore the importance of infection prevention & control measures #IPC as viable clade Ib #MPXV contamination can occur during treatment of #mpox patients

#IDSky #EpiSky #MedSky #PublicHealth

Colourful i-Base graphic. The main text reads: Mpox vaccine. People living with HIV need 2 doses, plus booster. At the top is a URL: I hyphen base dot info. At the bottom it says, subscribe by email. A smaller, tilted square graphic on the right, reads: HTB news. 2025. HIV treatment, prevention, access, and more. The colours used in the image are two shades of dark blue, three shades of light green, mustard, teal, orange, red, and white.

People living with #HIV need 2 shots of #mpox vaccine, plus booster after 2 years:

i-base.info/htb/50751

New data show the MVA-BN vaccine is less effective in #PLWH. Including in those with high CD4 counts.

#HIVsky #IDsky #Medsky #mpox2025 #MPXV #HIVresearch #PublicHealth @thelancet.bsky.social

Epidemiological update, 14 January 2025: Mpox due to monkeypox virus clade I In recent months there have been reports of monkeypox virus clade I cases in different EU/EEA countries following the geographic expansion of monkeypox virus clade I since mid-2024. This epidemiologic...

First instances of confirmed transmission of #MPXV clade I among close contacts of imported cases within the EU/EEA have been reported by Germany & Belgium.

ECDC is in contact with public health authorities in these countries regarding this development.

bit.ly/3Pyo63Y

reminder #MPXV ☣️

#Affenpocken

#CovidIsAirborne

#MpoxIsAirborne

wear KN95 or better ✅️

An illustration by John Waters. The top part of a viral particle in peach, with lilac and light green protrusions. The background is a mosaic of small dark pink pentagons.

#Mpox news:

Cases of mpox breakthrough infections despite two doses of the MVA-BN vaccine and high CD4 counts:

i-base.info/htb/49243

#HIV #HIVcoinfection #SexualHealth #mpox2024 #MpoxResponse #MPXV

An illustration by John Waters. The top part of a viral particle in peach, with lilac and light green protrusions. The background is a mosaic of small dark pink pentagons.

#Mpox news:

Cases of mpox breakthrough infections despite two doses of the MVA-BN vaccine and high CD4 counts:

i-base.info/htb/49243

#HIV #HIVcoinfection #SexualHealth #mpox2024 #MpoxResponse #MPXV

You had 50:50 chance

And you denied airborne transmission

You ignore the most vulnerables are toddlers & babies

#mpox aren't gender specific

People also transmit #MPXV asymptomaticaly

Clades are in full evolution without mitigations

continue to believe cause is all men having sex with you🤣

Do you know #MPXV #mpox #Affenpocken can also be airborne?

So think about #prevention especially in #Healthcare

😷

📌 #Affenpocken #MPXV #MPOX #monkeypox

🎯Outbreak Locator Human Cases 2024

Just in:
🔵First case of clade I MPOX in Canada (Manitoba).
This is a travel-related case, associated with the clade I mpox outbreak in central and eastern Africa #MPXV

🗺️Outbreak Locator dashboard: bddataplan.nl/outbreakloca...

Two enantiomers (mirror images) of a helix made by wrapping moelcules around a couple of iron atoms. The left handed one binds ten times more strongly to a G-quadruplex in Mpox virus than the right.

Still stunned that one metallohelix enantiomer stabilizes a new G-quadruplex in #mpox #mpxv virus RNA, so increasing expression of a protein that activates immune response. Chemistry by my team but amazing biology by Xiaogang Qu and his collabs. doi.org/10.1093/nsr/...

🎯Outbreak Locator Human Cases 2024

🔵De #MPOX clade 1 variant in Afrika was groot nieuws. De eerste patiënt in Europa (Zweden) ook, daarna werd het stiller
🆕Nieuw WHO-rapport toont een flinke toename in delen van Afrika 👀
Check en voeg toe: bddataplan.nl/outbreakloca...
#H5N1 #MPXV 1e post Bluesky👋🤓

Es sollte beachtet werden, dass Notfall Sanitäter mit adequater Schutzausrüstung ausgestattet werden für jeden Einsatz. Derzeit geht das vollkommen unter und Personal, sowie Patienten werden unnötig luftübertragenen Erregern ausgesetzt, die die Situation verschärfen.
#Covid #MPXV #Ebola #Prävention

SNAPDATE: MPOX cases in Australia, 14.09.2024 MPOX, the disease resulting from Monkeypox virus (MPXV) infection, continues to rise rapidly in Australia, as elsewhere in the world. It is unclear if Australia has rolled out more testing now or whet...

“…most detected cases occur among those 25-44 years of age, especially 30-40 in the older years. Although not shown, all 737 Australian infections have been detected among males.” #PublicHealth #mPox #MonkeyPox #DataViz #MPXV #InfectiousDiseases

TWiV 1141: Being green with the Red Queen TWiV discusses the spread of monkeypox virus clade 1b in Africa, COVID drops to tenth leading cause of death in the US, response to detection of poliovirus in Gaza, mechanism of MIS-C after SARS-CoV-2...

Somewhat annoyed with some people spreading rumors that #mpox virus #MPXV can be transmitted via airborne aerosols.

There is no evidence it is respiratory.

Y'all should listen to Prof Rich Condit on This Week in Virology. He's a expert in pox viruses.

www.microbe.tv/twiv/twiv-11...

Multi-country outbreak of mpox, External situation report#32- 30 April 2024 Edition 32

"...WHO is issuing an update of interim guidance on Diagnostic testing for the monkeypox virus ( #MPXV ) … The new interim guidance will supersede the version published on 9 November 2023..."

www.who.int/publications...

#mpox #ViroSky #IDSky

Schimmelpilze soo wichtig ☣️

Atemschutz tragen zur Sanierung!

Peressigsäure einwirken lassen!

beides ebenfalls hoch effectiv gegen andere biologische Gefahren!

So auch gegen

#SarsCov2 = #CORONA

#Affenpocken = #MPXV