#NatMetab

In vivo itaconate tracing reveals degradation pathway and turnover kinetics - Nature Metabolism In this study, Willenbockel et al. trace circulating itaconate in vivo to gain insight into its fate and systemic metabolism.

In vivo itaconate tracing reveals degradation pathway and turnover kinetics #NatMetab #MassSpec www.nature.com/articles/s42...

Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism - Nature Metabolism By developing a method that allows detection of transient, low-abundance acyl-CoA species, Liu et al. provide a thorough characterization of coenzyme A dynamics and subcellular partitioning.

Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism #NatMetab #MassSpec www.nature.com/articles/s42...

Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke - Nature Metabolism Wang et al. report a workflow to perform quantitative mass spectrometry imaging and provide insight into spatial metabolic remodelling undergone in the mouse brain upon ischaemia.

Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke #NatMetab #MassSpec www.nature.com/articles/s42...

Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of 13C-labelled glucose metabolism - Nature Metabolism Tsyben et al. study the spatial distribution of labelled metabolites in glioblastoma samples from patients infused with 13C-glucose, using mass spectrometry imaging.

Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of 13C-labelled glucose metabolism #NatMetab www.nature.com/articles/s42...

#PolyamineMetabolism #SkeletalMuscle #Aging

Depletion of S-adenosylmethionine (SAM, methyl donor) ➡️loss of #Heterochromatin➡️#MuscleStemCell #Aging

⏫SAM or⏬#SpermidineSynthase by MCHA▶️
⏫#SkeletalMuscle regeneration

#NatMetab 2024
www.nature.com/articles/s42...
pmc.ncbi.nlm.nih.gov/articles/PMC...

AI-driven framework to map the brain metabolome in three dimensions - Nature Metabolism This study presents MetaVision3D, a pipeline to integrate mass spectrometry imaging sections into 3D reconstructions of metabolomic maps. The authors also provide a comprehensive 3D metabolome atlas o...

AI-driven framework to map the brain metabolome in three dimensions #NatMetab #MassSpec www.nature.com/articles/s42...

Discovery of metabolites prevails amid in-source fragmentation - Nature Metabolism Nature Metabolism - Discovery of metabolites prevails amid in-source fragmentation

Discovery of metabolites prevails amid in-source fragmentation #NatMetab www.nature.com/articles/s42...