The molecular basis of force selectivity by PIEZO2 - Nature PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

The #molecular basis of #forceselectivity by #PIEZO2

www.nature.com/articles/s41...

📰New & Featured | #PIEZO2 is a regulator of juxtaglomerular granular cell calcium dynamics and #renin
🔸PIEZOs loss ablates mechanically activated currents in vitro
🔸PIEZO2 suppresses renin in hypervolemia/normovolemia and is a brake on the hormonal response to hypovolemia

Last talk in the #BiomembraneDays25 (before the best poster awards @lipotype.bsky.social ) is given by Thomas Weikl who explains nano-dome membrane deformations by #Piezo2
@mpici.bsky.social

Activity-dependent development of the body’s touch receptors Santiago et al. report that the mechanosensitive ion channel Piezo2 is required for the transcriptional and structural maturation of the primary sensory neurons that detect gentle touch and that Piezo...

Mechanically evoked neuronal activity via Piezo2 and Nav channels is essential for the development and structural maturation of mechanosensory end-organs underlying gentle touch. #Mechanotransduction #Piezo2 www.cell.com/neuron/fullt...

A recent review from Mahima Bose and the lab at COIN: "A neurobiology perspective on the assembly of retinal vasculature from 2D to 3D" #retina #neurovascular #neurobiology #Piezo2 #development #neurodegeneration #vascularbiology sciencedirect.com/science/arti...

Image with text: The image features a detailed black-and-white scan of a developing heart on a solid black background. Thin blue lines highlight the early vascular structure. Explanation of scientific image: In this image taken during a late embryonic stage of a mouse heart, the developing coronary arteries have been stained turquoise using antibodies. The tissue was made transparent using tissue clearing and the image was taken using a light sheet microscope. The overlaid text reads “HOW THE EARLY HEART DEVELOPS” in all-caps white sans-serif font, placed within a green rectangular background near the bottom of the image.

🫀 From sensing touch to shaping the heart – #PIEZO2 does more than we thought.

A new study from the Hammes Lab at #mdcBerlin shows that it plays a role in normal coronary vessel development and congenital heart disease.

Read the full story:
👉 www.mdc-berlin.de/news/news/ho... 👈

Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility The gut microbiota plays a crucial role in the manifestation of intestinal dysfunction associated with irritable bowel syndrome (IBS). The mechanosensory Piezo2 has been implicated in the regulation o...

🧠💩 Pain in the Gut: Fusobacterium varium bacteria triggers IBS symptoms by hijacking Piezo2 signaling #GutMicrobiome #Piezo2 #VisceralHypersensitivity #Neurogastroenterology pmc.ncbi.nlm.nih.gov/articles/PMC...

A novel mechanism behind episodic neuropathic pain—the interaction between dynamic blood vessel movements and Piezo2 mechanoreceptors in sensory neurons #piezo2 #neuropathicpain #nociceptors buff.ly/e5os312 @tbertalab.bsky.social

#Piezo2 as Pulmonary Microvascular #EndothelialCell shear sensor

Piezo2, Not #Piezo1, downregulated in
1⃣EC + Hypoxia/TGFβ2
2⃣4 animal #PulmonaryHypertension
3⃣Human iPAH🫁EC

siRNA Piezo2->#EndMT

Daphne Merkus lab #AJPHeartCirc 2022
journals.physiology.org/doi/full/10....

#PhosphoLipaseD #Mechanotransduction

Selective inhibition of #Piezo2, not #Piezo1 in sensory neurons by (intracellular) #LysophosphatidicAcid #PhosphatidicAcid, PLD enzymatic product

Optogenetic PLD
FIPI (PLD inhibitor)

bioRxiv 2024
www.biorxiv.org/content/10.1...