Enhancer profiling uncovers Jmjd1c as an essential suppressor in neuropathic pain by targeting Socs3

Super-enhancer–regulated #Jmjd1c suppresses #NeuropathicPain via the Socs3/JAK/STAT3 pathway, but its downregulation due to reduced KLF15 recruitment drives inflammation and NP progression, highlighting a potential therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...

👉Low-intensity focused ultrasound-activated piezoelectric gel bandage for diabetic wound repair and #neuropathicpain relief, by #Nature

✅ www.nature.com/articles/s41...

#EquipoDrAlfonsoVidal #UnidadDelDolor #RechaceImitadores #SomosUnicos #EnAlcorcónDesde2002 @quironsalud-qs.bsky.social

What do you think of the results of Tabacof et al.’s RCT reporting durable improvements in #neuropathicpain after using a novel audio-visual stimulation #neuromodulation device? Check out this #PRF #EditorsPick from @drjerinmathew.bsky.social bit.ly/4db4ccE

PRF 1 April 2026

What do you think of the results of Tabacof et al.’s RCT reporting durable improvements in #neuropathicpain after using a novel audio-visual stimulation #neuromodulation device? Check out this #PRF #EditorsPick bit.ly/4db4ccE

Redirecting

🎯Published in Healthcare and Rehabilitation: Ultrasound-guided PNS reduced anterior neck PHN pain with sustained 1-year benefit and no complications.
🔗 doi.org/10.1016/j.hc...
#PHN #NeuropathicPain #PNS #PainManagement

International Neuropathic Pain consortium awarded €1.4m grant | King's College London DECIPHER, an international consortium on Neuropathic Pain led by King’s College London, has been awarded €1.4m by ERA-NET Neuron to research the role of connective tissue in neuropathic pain.

@denklab.bsky.social leads an international consortium awarded €1.4m by @eraneuron.bsky.social to research causes and treatments for #NeuropathicPain.

@mwklab.bsky.social @carolineospelt.bsky.social are also chief investigators.

@nihrmaudsleybrc.bsky.social
www.kcl.ac.uk/news/interna...

#EditorsChoice in #JPP: Intranasal #donepezil-loaded nanostructured lipid carriers show promise as a therapeutic strategy for #NeuropathicPain.

Read the full study in #JPP:

🔗 doi.org/10.1093/jpp/...

➡️ Giovane Galdino et al.

Half of Patients With NMOSD Have Neuropathic Pain, Often Linked to Thoracic Spinal Cord Lesions Neuropathic pain is highly prevalent in NMOSD, with links to structural spinal cord damage and AQP4-mediated immunopathology.

Neuropathic pain is a highly prevalent yet insufficiently managed complication of neuromyelitis optica spectrum disorder (#NMOSD), according to findings of a recent meta-analysis published in Journal of Clinical Medicine.

Read more: https://bit.ly/47jDOt1

#RareDisease #NeuropathicPain #MedSky

Prescribing #monopharmacotherapy for #neuropathicpain rather than combination pharmacotherapy is associated with a lower likelihood of #treatmentdiscontinuation www.bjanaesthesia.org/article/S0007-0912(25)00...

🧠 Athina Karavasopoulou explores neuropathic pain, focusing on its causes, symptoms and what this means for nursing assessment and management.

Read more. Link in thread.

#PainManagement #NeuropathicPain #NursingPractice #LongTermConditions #BJNinform #CPD

Pharmacotherapy and non-invasive neuromodulation for neuropathic pain: a systematic review and meta-analysis Our results support a revision of the Neuropathic Pain Special Interest Group recommendations for the treatment of neuropathic pain. Treatment outcomes are modest and for some treatments uncertainty r...

Recommendations for #NeuropathicPain:
1st: TCAs, SNRIs, α2δ-ligands
2nd: Topicals (capsaicin, lidocaine)
3rd: rTMS, botulinum toxin, opioids (caution)
📄 Full study: www.thelancet.com/journals/lan...
#ChronicPain #Neuromodulation

🔍 #NeuropathicPain guidelines from @iasp.bsky.social P #rTMS now a 3rd-line option with NNT=4.2 - comparable to 1st-line drugs!
Why rTMS?
✔ Non-pharmacological for refractory patients
✔ High safety (NNH=651.6)

Neuropathic Pain Causes, Symptoms, Medication, & Treatment What causes neuropathic pain (nerve pain) and how is it treated? Learn about nerve pain symptoms, medications, and prevention.

tinyurl.com/mvdhay43
#Pain is #unique to everyone. As such, the words used to describe #neuropathicpain may vary. Frequent descriptions include #pricking, #tingling, #burning, #stabbing, or #aching.

An Overview of Neuropathic Pain and Its Impact - International Association for the Study of Pain (IASP) An Overview of Neuropathic Pain and Its Impact Authors: Keith M Smart, BSc (Hons) Physio, MSc, PhD: UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland. [...

tinyurl.com/bdhpvs9c
This suggests that as many as #oneineveryten #adults could be experiencing #neuropathicpain.

How Do I Describe Chronic Pain to My Doctor?

" #NeuropathicPain is a common type of #ChronicPain & it comes & goes. Sometimes, it’s so severe that it prevents patients from being able to do everyday activities..also interferes with #movement which can lead to #mobility issues.": buff.ly/rzGwmOl

by @carriekellenberger.bsky.social
#spoonie

This study reports that suppression of #Jmjd1c, driven by reduced recruitment of KLF15, downregulates #Socs3 via #H3K9 #Demethylation, leading to #NeuropathicPain, highlighting a key #Epigenetic mechanism in #disease development. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

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@neuropathic.pain
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China Neuropathic Pain Market Size, Growth Report 2035 China Neuropathic Pain Market Industry is expected to grow from 403.12(USD Million) in 2024 to 986.18(USD Million) by 2035. The China Neuropathic Pain Market CAGR (growth rate) is expected to be aroun...

⚡ China’s Neuropathic Pain Market is expanding with innovative treatments and rising awareness of chronic pain management. Explore full insights: www.marketresearchfuture.com/reports/chin... #NeuropathicPain #China #Pharma #MarketResearch

UK Neuropathic Pain Market Size, Growth Report 2035 UK Neuropathic Pain Market is expected to grow from 348.3(USD Million) in 2024 to 693.6(USD Million) by 2035. The UK Neuropathic Pain Market CAGR (growth rate) is expected to be around 6.462% during t...

⚡ The UK Neuropathic Pain Market sees rising demand for innovative therapies & pain management. Full study: www.marketresearchfuture.com/reports/uk-n... #NeuropathicPain #UK #Pharma

#MentalHealth #PTSD #Nightmares #CPTSD #ChronicPain #NeuropathicPain #Fibromyalgia #Migraine #Spoonie #SpoonieLife #PsychMed #Olanzapine #Zyprexa #TraumaRecovery #SleepDisorders #MedicationAwareness #OffLabelUse

Presenting my poster today at #NeuPSIG2025 Come to chat with me to learn more about the predictors of neuropathic pain medication prescribing and persistence in Scotland.

#painresearch #neuropathicpain

AlzeCure to present promising pain therapy ACD440 at NeuPSIG 2025 - PharmaTimes Clinical results from phase 2 study highlight analgesic effects in neuropathic pain patients

#AlzeCure #AlzeCurePharma #pain #paintherapy #ACD440 #NeuPSIG2025 #neuropathicpain #peripheralneuropathicpain #TRPV1antagonist #heatinducedpain #strategicinlicensing #inlicensing #painrelief #painkillers #opioidcrisis #painprecisionmedicine #chronicneuropathicpain
pharmatimes.com/news/alzecur...

Shingles Pain and Trigeminal Neuralgia Relief - Red Butte Pain Solutions Shingles pain management is key to preventing trigeminal neuralgia symptoms. Learn causes, treatments, and prevention.

Shingles pain can be devastating—especially in the face. Learn about shingles pain management, trigeminal neuralgia symptoms, and effective relief.
🔗 redbuttepain.com/shingles-pai...
#ShinglesPain #TrigeminalNeuralgia #PainManagementChandler #NeuropathicPain #NervePain #PHN #FacePain

Shingles Pain and Trigeminal Neuralgia Relief - Red Butte Pain Solutions Shingles pain management is key to preventing trigeminal neuralgia symptoms. Learn causes, treatments, and prevention.

Shingles pain can be devastating—especially in the face. Learn about shingles pain management, trigeminal neuralgia symptoms, and effective relief.
🔗 redbuttepain.com/shingles-pai...
#ShinglesPain #TrigeminalNeuralgia #PainManagementChandler #NeuropathicPain #NervePain #PHN #FacePain

New research!

Scientists demonstrate that KLF15 activates #Jmjd1c transcription, which in turn suppresses #NeuropathicPain degeneration through modulation of the Socs3/JAK/STAT3 signaling cascade, establishing a novel regulatory axis with promising therapeutic potential.

Our most recent webinar on neuropathic pain, along with other past webinars, can all be found on our YouTube channel: youtube.com/@foundationforperipheral...

Thanks Brian Callaghan, MD, and our sponsor Lilly!
#neuropathicpain #neuropathy #neuropathywebinar

49 Take-off projects awarded in spring round 2025 | NWO 38 feasibility studies and 11 vroegefasetrajecten have been awarded in the 2025 spring round of Take-off. The Take-off program gives researchers in phase 1 the opportunity to test the feasibility of commercializing their idea based on innovative research results. In phase 2, knowledge-based, innovative start-ups in the early stages of their development receive a loan to get their business off the ground.

3 projects by the LED3 researchers Nathaniel Martin, Anthe Janssen and Mirjam Huizenga have been awarded NWO Take-off funding to explore commercial development of compounds and technologies with applications in #oncology, #NeuropathicPain treatment and #kinase research!
www.nwo.nl/en/news/49-t...

TOMORROW
There are many ways to treat nerve pain. Learn about treatments, limitations and possible costs for neuropathic pain. Register today
register.gotowebinar.com/register/557562831041303...
#peripheralneuropathy #peripheralneuropathywebinar #neuropathicpain

New Cancer Control study reports that adding mirogabalin to low-dose duloxetine significantly eased taxane-induced neuropathy in lung cancer patients. A promising combination for tackling CIPN where monotherapy falls short. #CIPN #LungCancer #SupportiveCare #Oncology #NeuropathicPain

👉Last week #PHOTOTHERAPORT team met at
@IBECBarcelona for our 18-month project meeting. 2 days of intense and fruitful discussions to define next steps in our #photopharmacology strategy: light-emitting implants + photo-controlled drugs to treat #neuropathicpain & #epilepsy. 💡🧠
#EUeic #EUResearch