A cellular perspective
What #polycythemia looks like
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In @jem.org, Zhou et al. reveal that heterozygous JAK2V617F variant in megakaryocyte-erythroid progenitors drives essential #thrombocythemia via STAT1-IDO1-AhR-RUNX1, whereas the homozygous JAK2V617F variant promotes #polycythemia vera through the activation of STAT5. rupress.org/jem/article/...
Zhou et al. reveal that heterozygous JAK2V617F variant in megakaryocyte-erythroid progenitors drives essential #thrombocythemia via STAT1-IDO1-AhR-RUNX1, whereas the homozygous JAK2V617F variant promotes #polycythemia vera through the activation of STAT5. rupress.org/jem/article/...
Polycythemia
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First treatment for Secondary Polycythemia. #polycythemia #lackscancercenter
I have several incurable diagnoses that desperately require research funding. Defying court orders is illegal.
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🩸 Polycythemia workup algorithm #hemesky #MedSky #IMsky #polycythemia