Novel Therapeutics and Discoveries | Leo D. Wang, MD, PhD Our conversation with Leo D. Wang, MD, PhD, includes unique insights into novel discoveries and therapeutics for HIV, diabetes, cancer and other conditions. As the director of the City of Hope Alpha Clinic, we discuss the innovative and collaborative nature of the California Institute for Regenerative Medicine (CIRM) Alpha Clinic network. The City of Hope was the first of now nine CIRM Alpha Clinics, designed to improve patient access to stem cell and regenerative medicine clinical trials for all Californians. Leo Wang also serves as an associate professor in the Departments of Pediatrics and Immuno-Oncology, and the division chief of cell, gene, and transplantation therapy at City of Hope, a cancer hospital located outside of Los Angeles, CA, with additional affiliate locations. He leads a research lab dedicated to reprogramming the immune system to fight childhood cancers, where his team works to modify the body’s own immune cells to target and destroy cancer cells. Additionally, his lab studies how these engineered cellular therapies interact with tumors and the native immune system. Wang also oversees clinical trials that use these “living medicines” to treat pediatric brain tumors and other aggressive cancers. Hosted by Bobby Gordon, MA, MBA This episode was recorded on Oct. 17, 2025, and information is current as of the time of this recording. Find more episodes: https://stemcellpodcast.org

bit.ly/3NO9OiN 🎙️ Tune in to our reGEN Podcast with
Leo D. Wang, MD, PhD - City of Hope - for insights on the
@cirmnews.bsky.social Alpha Clinic network & breakthroughs in pediatric #cancer; from engineered cell therapies to “living medicines,” advancing care for aggressive cancers. #stemcells

Effects of Exosomes from Menstrual Blood-derived Stem Cells and Ginger on Endometriotic Stem Cells

This study demonstrates that natural #Exosomes can reprogram #GeneExpression in #Endometriotic #StemCells toward healthier states, with plant derived exosomes showing cost effective promise as #NaturalTherapies for #Endometriosis. #medsky

To read: doi.org/10.1007/s115...

Qkine are exciting to be supporting iPSC research in Zurich, Switzerland as we exhibit at the @iPSZürich 2026 Symposium on the 10th April.

More about the event > zurl.co/C7KPk

#stemcells #recombinantproteins #research

#stemcells

Weekly reads: 1st FDA-approved CIRM supported therapy, asymmetric histone inheritance, stem cell retraction - The Niche Biologist discusses recent regenerative news including 1st FDA-approved CIRM TX, asymmetric histone inheritance, and skin cell memory.

Weekly #regenerative reads: 1st FDA-approved CIRM supported therapy, asymmetric histone inheritance, stem cell retraction ipscell.com/2026/04/week... #stemcells

Organoids + AI is the convergence everyone in the field is watching right now. ML is being used to stabilize culture conditions, segment morphology in real time, and integrate imaging with spatial omics.
#organoids #stemcells #neuroscience

🧬 Japan approved the world's first 2 iPS cell medicines — and researchers are making "universal blood" from stem cells that works for ANY patient, no blood-type matching needed.

20 yrs after Yamanaka's Nobel, iPS Cell 2.0 is here.

#iPSCell #RegenerativeMedicine #StemCells

Quick guide: Stem cells are undifferentiated cells for self-renewal & specialization! 🧬 Embryonic, iPSCs; properties like self-renewal; apps in regenerative med, tissue eng.
Master with BioResire—contact for internships!
Join: whatsapp.com/channel/0029...

#StemCells #BioResire #StemCellsGuide

SSR Podcast – Society for the Study of Reproduction The Future Conceived The Future Conceived podcast is the official podcast for the Society for the Study of Reproduction. In this podcast, you’ll hear about emerging scientists, new techniques, investigators from around the world, untold stories about our annual conference, and so much more!

Listen here 🎧 https://ssr.org/ssr-resources/ssr-podcast/

#StemCells #BioTwitter #SciComm

🧠 Stem cell therapies are opening new possibilities for neurological disorders like AD, PD, stroke & MS.

From neuroregeneration to precision medicine, this review highlights key advances—and remaining challenges.

📖 dr.clintile.com/article/doi/...

#StemCells #Neuroscience #RegenerativeMedicine

🧬 New Research Alert

KLF2 enhances ellagic acid–induced osteogenic differentiation of dental pulp stem cells via autophagy & mitochondrial regulation.

💡 A promising mechanism for regenerative medicine

🔗 dr.clintile.com/article/doi/...

#StemCells #Osteogenesis #RegenerativeMedicine

Rita Perlingeiro and Karim Azzag

Dra. Rita Perlingeiro and Karim Azzag share their insights on the "Progress on cell therapy for skeletal muscle disorders" in the Advanced Drug Delivery Reviews. A must-read for those following the latest in iPSCs & muscle regeneration.

Link: z.umn.edu/perli-azzag-...

#Medicine #StemCells #iPSCs

My favorite weird & not-so-weird but cool science pictures from 16 years of The Niche: Part 1 - The Niche Professor discusses his favorite weird and not-so-weird science pictures from 15 years of The Niche including some related to stem cells.

My favorite weird & not-so-weird but cool science pictures from 16 years of The Niche: Part 1 ipscell.com/2026/04/my-f... #stemcells #stemcell including this flesh-faced "robot"

At that moment, Rosaria was listening to Life on Mars? by David Bowie, an unexpectedly perfect match for a scene that felt more like a distant planet than a dish of living cells.

#sciart #stemcells #neuroscience #microscopy #cellbiology #scienceisbeautiful #artinscience

Qkine has optimized the manufacturing process of its stem cell factor (SCF) to produce a highly bioactive protein with excellent lot-to-lot consistency for enhanced experimental reproducibility > zurl.co/n6SLt

#stemcells #research #growthfactors

A photograph of UCLA's Dr. Donald Kohn wearing a blue shirt and tie with a white lab coat. There is a quote overwriting the image. The quote reads, "I saw a marked improvement across all patients in terms of restored immune function. Witnessing that these patients no longer battle life-threatening infections has been incredibly meaningful." Attribution is: Distinguished professor of microbiology, immunology and molecular genetics Dr. Donald Kohn

How does the FDA-approved LAD-I gene therapy work?

Doctors take the patient's OWN stem cells, add a healthy copy of the mutated gene, and return them. No donor needed. No transplant rejection risk.

All 9 trial patients: restored immune systems.

🔗 lnkd.in/gDJzjgvx

#GeneTherapy #StemCells

Problems to be solved in the clinical application of MSCs.

🧪 Can natural compounds improve MSC therapies?

MSCs show promise—but inconsistent outcomes.

🌱 Natural products may:
boost survival & homing，guide differentiation， enhance immune regulation
⚠️ Multi-target strategies could be key.
🔗 www.sciencedirect.com/science/arti...
#StemCells #NaturalProducts

As a medical school professor, I've taught about blood transfusions for decades. But this study from Aging Cell just showed that removing blood may be even more p... onlinelibrary.wiley.com/doi/full/10.1111/acel.70...

#AntiAging #MetabolicHealth #Longevity #StemCells #HealthLongevitySecrets

Epigenetics Update - Stage-specific epigenetic priming amplifies gene activation during lineage commitment bit.ly/4s3qDnN

Arion Foertsch and Asifa Akhtar in PNAS

#Epigenetics #StemCells #NPCs
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Gain deeper insights into gene regulation; epigenometech.com

🩸 #sfh2026 #Hematology #OncoHematology #Waldenström #IWMF #Immunology #Lymphoma #WomenInSTEM #GustaveRoussy #WeillCornell #StemCells #ApostolouLab #MelnickLab

Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo Cai et al. used a Perturb-seq platform to systematically identify in vivo pathological barriers to cardiac reprogramming in infarcted mouse hearts. Calreticulin emerged as the top-ranked inhibitory factor, reducing calcium to inactivate MEF2C. Targeting this pathway boosted induced cardiomyocyte efficiency and function, revealing a potent regenerative target.

Online Now! Perturb-seq uncovers pathological obstacles to direct cardiac reprogramming in vivo #stemcells

Weekly reads: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit - The Niche Professor discusses regenerative news: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit

ICYMI: Weekly #stemcell & #regenerative reads: Gattaca stack, animal sacks, custom iPS cells (is it worth $40K+?), ImmunityBio FDA warning, mouse cloning limit finally reached ipscell.com/2026/03/week... #stemcells

The modulation of MSCs with natural products.

🧬 Natural products → better MSC therapies 🧪

↑ homing, survival, differentiation
↑ immune regulation & oxidative balance
Key compounds: phenols, flavonoids, terpenoids

Framework for regenerative medicine

🔗 doi.org/10.1016/S187...

#StemCells #RegenerativeMedicine #TCM #CJNM 🧪

❓A one-time, durable, and even reversible way to prevent thrombosis? In this preprint, led by @lrbzldz.bsky.social, we show that epigenome editing of 🩸 #StemCells can durably reprogram platelet function: www.biorxiv.org/content/10.6...

📄 New review in JND

Satellite cells are central to muscle regeneration and a growing class of disorders termed satellite cell-opathies.

Emerging therapies include gene editing, cell therapy, and niche-targeting drugs.
Read the full review here: buff.ly/n5brzO7

#StemCells #RareDisease

Japan grants conditional approval to Amchepry for Parkinson’s Japan granted conditional approval to Amchepry, a stem cell-derived therapy for Parkinson’s disease, based on early clinical trial results

🧠 Japanese 🇯🇵 pharma company #Sumitomo has received approval to mass-manufacture a pioneering #StemCells treatment that regenerates dopamine-producing brain cells. Early trials showed over half of #Parkinsons participants showing signs of recovery with no adverse effects. 🌟

Weekly reads: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit - The Niche Professor discusses regenerative news: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit

Weekly #regenerative reads: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit ipscell.com/2026/03/week... #stemcells #stemcell

We’ve been told to eat 3 meals a day.. starting with breakfast as soon as we rise, but why? 🧐 I skip breakfast, and intermittent fast (only eat 12pm-8pm). Fasting gives your body time to heal.. especially while you sleep.

🍽️

#Kellogs #Breakfast #Fasting #Healing #StemCells

Paralyzed Man Regains Use of Arms and Hands After Experimental Stem Cell Therapy - Neuroscience News Researchers inject an experimental stem cell treatment into the damaged cervical spine of a recently paralyzed young man, restoring a level of function into his hands and arms.

Paralyzed after a car crash, regains use of arms with stem cells therapy
#stemcells
neurosciencenews.com/stem-cell-pa...

Engineered MSCs enable bone marrow-targeted immunomodulation Zhang and colleagues developed a bone marrow-targeted, tumor-evasive cell vector that enhances systemic immunity without stimulating tumor growth. By delivering protective or immune-restorative signals directly to immune organs rather than to the tumor itself, their strategy reframes cancer therapy as systemic immune reprogramming instead of localized tumor attack.

Online Now! Engineered MSCs enable bone marrow-targeted immunomodulation #stemcells