Thanks to the @proteinsociety.bsky.social for organising an excellent virtual seminar on structural biology of #TRPchannels at different temperatures. Inspiring talks by Alexander Sobolevsky, Juan Du and David Julius, chaired by Yifan Cheng.

Can a blind retina be made sensitive to infrared light? Our team shows that an engineered human TRPV1 channel, delivered by AAV, elicits robust responses without foreign proteins or nanoparticles.
🔗 bit.ly/4gt0LO5
#AcademicBlueSky #ProteinEngineering #TRPChannels #SyntheticBiology #Vision #Retina

Took a TRP to beautiful Leuven and the sensory neurons are all firing....
Came for the Belgian 🍫,
stayed for the🌶🧅 🧊
#TRPChannels #LipidLove

#ProteinEngineering #TRPChannels #SyntheticBiology #VisionRestoration #Retina #GeneTherapy

#TRPchannels mediate cellular responses to various #NaturalProducts. #EnglerinA (EA), found in a plant used as a traditional medicine and a poison, is a potent and selective TRPC1/4/5 activator. However, how EA interacts with these channels has remained a mystery – until now.

#ThrowbackThursday Special Topic article in JHC: "Transient Receptor Potential Channels in the Healthy and Diseased Blood–Brain Barrier."

Click to read for FREE: bit.ly/3JPKZ0h

#bloodbrainbarrier #neurology #TRPchannels

Structural insights into TRPV2 modulation by probenecid Nature Structural & Molecular Biology - The authors reveal that probenecid, an FDA-approved drug, uniquely modulates TRPV2 through an intracellular pocket. Probenecid drives the channel into an...

Congrats Julia Rocereta & Moiseenkova-Bell Lab on your Nature Structural & Molecular Biology publication: "Structural insights into TRPV2 modulation by probenecid"
#cryoEM #TRPV2 #TRPchannels

www.nature.com/articles/s41...

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

"Human TRPA1 activity is suppressed by caffeine (Figure 10), whereas in mice this ion channel is stimulated by caffeine."

doi.org/10.1177/0960...

#MouseVsHuman #MouseModel #Mice #TRPA1 #TRPchannels #caffeine #pain #neuroscience #biology

Redirecting

research article from 2016:
Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism
doi.org/10.1016/j.bb...

#ALDH2 #TRPV1 #TRPchannels #mitochondria #ToRead

Busting Myths and Offering Unique Leg Cramp Remedies What causes muscle cramps? Hint: They're NOT brought on by dehydration or electrolyte imbalance. Triggering TRP channels with leg cramp remedies might help.

Busting Myths and Offering Unique Leg Cramp Remedies www.peoplespharmacy.com/articles/bus... via @peoplespharmacy
#legcramps #musclecramps #remedies #TRPchannels