MTA1-mediated transcriptional repression of Cox2 confers resistance against neutrophil infiltration in endometritis - Genes & Immunity Genes & Immunity - MTA1-mediated transcriptional repression of Cox2 confers resistance against neutrophil infiltration in endometritis

🌅 #Research #Alert
MTA1-mediated #transcriptional repression of #Cox2 confers #resistance against #neutrophil infiltration in #endometritis

@springernature.com #Genes & #immunity
www.nature.com/articles/s41...

Transcriptional regulation of ventral hippocampus-nucleus accumbens circuit excitability drives cocaine seeking ΔFosB induces calreticulin to decrease excitability of ventral hippocampus-accumbens projections and drive cocaine seeking.

#Transcriptional regulation of ventral #hippocampus- #nucleusaccumbens circuit excitability drives #cocaine seeking | Science Advances www.science.org/doi/10.1126/...

Delighted to share our new #preprint on #mastcell desensitization on @biorxiv-immuno.bsky.social

We show that #mastcell #desensitization involves #IgE internalization and induces distinct #immunoregulatory #transcriptional program linked to #immune regulation.

www.biorxiv.org/content/10.6...

Published in Horticulture Research, the study compares rapeseed with its two diploid progenitors and shows that regulatory features of duplicated genes become increasingly aligned after polyploidization.
#transcriptional balance #Brassica napus
Details: doi.org/10.1093/hr/uhaf266

El siguiente bloque de pláticas fue del grupo de @mgschiavon.bsky.social, y fue dada por Diego Morales, quien nos habló de #biestabilidad y #transcriptional #bursting #DiasAcademicos2026 @liigh-unam.bsky.social

This review traces milestones in #Tcell exhaustion research, detailing how metabolic, #epigenetic, and #transcriptional changes drive immune dysfunction, while evaluating emerging therapies, ongoing challenges, and future directions.

#OpenAccess in #STTT: doi.org/10.1038/s413...

IRF8 worsens NAFLD through the BMAL1/PPARγ axis, linking circadian regulation, metabolism, and hepatic inflammation—revealing promising therapeutic angles.
#NAFLD #LiverDisease #InflammationMechanisms #Lipogenesis #Transcriptional regulation
www.sciencedirect.com/science/arti...

Mechanistic model demonstrating secondary #metabolite-mediated #drought tolerance through #antioxidation, #osmoprotection, and #transcriptional regulation

www.sciencedirect.com/science/arti...

@plantsciencedbg.bsky.social @plantbiology.bsky.social @cp-trendsecolevo.bsky.social @cropxr.bsky.social

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ

schematic of genetic tagging of cells that respond preferentially to early-life stress, and then capturing ribosomally tethered transcripts in these same cells

Just dropped! 🧠🧪how to pinpoint brain cells activated by early-life #stress then determine their #epigenomic and #transcriptional changes that govern adult behaviors. Led by @amaliaflorious.bsky.social @svmahler.bsky.social @cate-cholamine.bsky.social @thebalelab.bsky.social doi.org/10.3389/fnin...

Transcriptional regulation of Ligase IV by an intronic regulatory element directs thymocyte development - Genes & Immunity Genes & Immunity - Transcriptional regulation of Ligase IV by an intronic regulatory element directs thymocyte development

#Transcriptional #regulation of #Ligase IV by an #intronic #regulatory #element directs #thymocyte #development

#Genes & #Immunity @springernature.com
www.nature.com/articles/s41...

Our study investigates #gene regulatory networks behind #Mimosa pudica leaf-folding response to mechanical stress, revealing distinct #transcriptional and #physiological changes after single and repeated disturbances, with implications for understanding #stress -induced #plant #defense mechanisms.

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease - Molecular Neurodegeneration Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, tau hyperphosphorylation, and neuroinflammation. The choroid ple...

'Early #transcriptional and cellular abnormalities in choroid plexus of a mouse model of #AlzheimersDisease'

Zhong-Jiang Yan, Maosen Ye, Jiexi Li, Deng-Feng Zhang, Yong-Gang Yao

molecularneurodegeneration.biomedcentral.com/articles/10....

Kudos to @raffaella.ergasti for presenting our ongoing work on #transcriptional #signatures underlying high-grade serous #ovariancancer subtypes in collaboration with Gemelli Hospital at @ESGO_society in Rome 🌟🌟🌟 well done 🙌🙌 #esgo2025

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease - Nature Neuroscience Using single-nucleus RNA sequencing from 32 donors, researchers identified distinct astrocytic gene expression programs activated across brain regions and Alzheimer’s disease stages. They also found u...

Interesting study: astrocye #transcriptional changes remates to #tau spreading during #Alzheimer’s disease progression

www.nature.com/articles/s41...

We just got here! 😀We study #transcriptional control of #inflammation, work on #macrophages, 😍 #NuclearReceptors - and 'long walks on the Upper East Side in #NYC Please, bear with us until we find our way around this place. Stop by to say hello!! Hard to find everyone 😃 @wcm-imp.bsky.social

Kroll Lab A website by WashU Sites

Just joined Bluesky--looking to connect with those interested in #embryology, #developmental biology, #molecular neuroscience, #autism and other #neurodevelopmental disorders, #epigenetic and #transcriptional regulation, and other interests nature, photography, travel, etc. sites.wustl.edu/krolllab/