Gender matters in the brain/bone axis. Buck scientists find that #APOE4 silently undermines bone quality in female mice: osteocytes may be a potential mid-life biomarker for both #osteoporosis and #Alzheimers www.buckinstitute.org/news/apoe4-t...
You can have any insulin level with exactly same Glucose.
Glucose alone is a terrible proxy for metabolic health.
We need to ask for fasting insulin.
#InsulinResistance #MetabolicHealth #BloodTest #FastingInsulin #APOE4
We are all unique "formulas" waiting to be solved.
Play the short MindCrowd.org memory game.
Help scientists find the personalized formulas we could use to keep our minds fit for life.
#MindCrowd #BrainHealth #PrecisionAging #AlzheimersResearch #APOE4
Source: Karolinska Institutet
🧵 2/2
As a medical school professor, I teach about APOE4 -- the gene that makes you 2.5x more likely to develop Alzheimer's. We've told patients there's nothing they can... jamanetwork.com/journals/jamanetworkopen...
#APOE4 #Alzheimers #MetabolicHealth #Nutrition #HealthLongevity
Looks like I will be chairing the Lightning Round session on Aging and Women’s Health in Alzheimer’s Disease and Related Dementia session at #AAIC2026. I’m very excited to share some of the #APOE4 specific lysosomal changes in the brains of female mice… See in London this July!
ApoE4.Info and ApoE4 Alzheimer's Alliance: A Bold Step for Advocacy in Alzheimer’s Research #United_States #Washington #Alzheimer's #Advocacy #ApoE4
Roche Unveils Breakthrough Blood Test for Alzheimer’s Gene Variant Detection #Roche #Switzerland #Alzheimer's #Basel #ApoE4
Roche's New Blood Test: A Breakthrough Tool for Alzheimer's Risk Assessment #Roche #Switzerland #Alzheimer's #Basel #ApoE4
Chris Hemsworth on Alzheimer’s Risk, Fame, and Fear
wiobs.com/chris-hemswo...
#ChrisHemsworth #AlzheimersAwareness #CelebrityHealth #APOE4 #LimitlessSeries #MentalHealth
4/4
These insights emphasize the potential for microbiome-targeted strategies to mitigate AD risk in genetically predisposed individuals. 🧠 buff.ly/iCwmNTz
#endalz #APOE4 #microbiome
📣 New Podcast! "Genetic Secrets: How to Maximize Your Lifespan" on @Spreaker #alzheimers #apoe4 #biomarkers #cardiovascular #cholesterol #diet #dna #exercise #genetics #healthspan #inflammation #lifespan #longevity #metabolism #nutrition #prevention #risk #sleep #smoking #wellness
🧠 ApoE4 lowers the p-tau217 #tauopathy threshold.
In two independent cohorts spanning preclinical and symptomatic #Alzheimer’s disease, the study tested where #ApoE4 accelerates the amyloid-to-tau transition.
🔗Read a summary of the study on our website: www.synergy-munich.de/news-events/...
Sauna isn’t about heat tolerance. It’s about dose.
2–3x/week = minimum effective
4–7x/week = optimal
Post-workout sessions amplify benefits.
Track it or it doesn’t compound.
Watch : https://youtube.com/shorts/uMZesBAcTp0?feature=share
#Sauna #APOE4 #BrainHealth #Longevity
New study: "In the #APOE4 group, lower adherence to a #plantbased pattern and higher adherence to an animal- and fat-rich pattern were both associated with poorer cognitive performance."🥦 🍄 #neurology #neurosky #dementia #Alzheimers @leadcoalition.bsky.social
www.mdpi.com/2072-6643/18...
New: "This case study could contribute to a greater understanding of protective lifestyle changes that delay #Alzheimers disease, specifically in patients who are homozygous for the #APOE4 gene." @leadcoalition.bsky.social #dementia #plantbased
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
#ferroptosis #oxidizedlipids #ApoE4 #toxicity #ABC4 #transport
bsky.app/profile/liga...
“Higher intake of high-fat cheese and high-fat cream was associated with a lower risk of all-cause dementia, whereas low-fat cheese. APOE ε4 status modified the association between high-fat cheese and AD.” #ISOGG #DNA #epigenetics #cheese #brie #APOE4 #dementia www.neurology.org/doi/10.1212/...
Wonderful talk by David Holtzman at the #NIH/#NINDS regarding #APOE and #AD, and Christchurch mutation. #APOE4 #APOE3ch #neurodegeneration
Check out this interesting study that identifies a potential rescue mechanism for APOE4 induced defects in neuronal proteostasis and synaptic plasticity.
www.life-science-alliance.org/content/9/2/...
#Alzheimers #APOE4
97% Accurate Blood Test BEATS Spinal Taps
This changes EVERYTHING for APOE4 carriers 🧬
A simple blood test just beat the invasive spinal tap:
• 97% vs 92% accuracy
• $300 vs $2,000
• No needles in your spine
• Available TODAY
#APOE4
youtube.com/shorts/O9-QB...
Figure 4N from the PNAS paper "Engineered 3D immuno-glial-neurovascular human miBrain model" (10.1073/pnas.2511596122) with the following caption: "miBrain reveals APOE4 astrocytes promote tau phosphorylation via crosstalk with microglia...schematic illustrating experiments testing the effect of APOE4 microglia-astrocyte crosstalk by applying CM from astrocyte monocultures and microglia monocultures versus microglia-astrocyte coculture"
The miBrain is the first human 3D brain platform to integrate six major cell types in a single culture.
The @picowerinstitute.bsky.social & @mitkochinstitute.bsky.social team used it to study the role of #APOE4 astrocytes in the pathology of #Alzheimers, a uniquely human disease.
#neuroskyence 🧪
Exploring Dr. Juan Fortea's Transformative Research on Alzheimer's Disease and Genetics #USA #Washington #Alzheimer's #ApoE4 #Dr._Fortea
Microplastics Linked to Alzheimer‑Like Brain Damage in Mice
Three‑week exposure to polystyrene micro‑and nanoplastics worsened memory in APOE4‑carrying mice; males showed reduced avoidance and females slower novel‑object recognition, the study reports. getnews.me/microplastics-linked-to-... #microplastics #apoe4
Mediterranean Diet May Counteract Genetic Alzheimer’s Risk, Study Finds
Researchers studied 5,700 people (1989‑2023) and found the Mediterranean diet lowered Alzheimer’s risk, even for those with two APOE4 copies, with strongest protection in the highest‑risk group. getnews.me/mediterranean-diet-may-c... #diet #apoe4
New research from Roche: New protocol for differentiating brain endothelial cells from iPSCs. In cells homozygous for #ApoE4, researchers show disrupted intracellular trafficking and impaired iron homeostasis. #neuroscience #Alzheimers ow.ly/l20p50WJMeC
@isscr.org
New 4-year Alzheimer's data:
- 69% of early patients: zero decline
- APOE4/4 carriers: 20% biomarker drop with oral pill
- Benefits double over time (not plateau)
- Start early = 27% better outcome
Not reversing damage, but finally bending the curve.
#AAIC2025 #Alzheimers #APOE4
youtu.be/DipVwic6pPI
Your blood test: "Perfect cholesterol!"
Your brain: "Actually... 🚨"
New AAIC 2025 research shows female APOE4 carriers can have ideal blood cholesterol while it's secretly building up in brain cells.
It's not how much. It's WHERE it's stuck.
youtube.com/shorts/el_Pi...
#BrainHealth #APOE4 #AAIC2025
Figure 6 from the paper linked in the second post. “Summary of neurodevelopmental consequences of APOE4. APOE4 alters the window of neurogenesis leading to premature neuronal maturation, shifting the balance from neurogenesis to gliogenesis, contributing to altered cellular composition of neurons and glia. In GEOs, APOE4 leads to premature GABAergic neuron maturation. Collectively, these changes are associated with heightened synchronicity and weakened inhibitory signaling in APOE4 assembloids, with APOE4 in COs being sufficient to drive functional changes.”
With human brain organoids generated from stem cell lines, researchers at @utsaroadrunners.bsky.social discovered how #APOE4, the top genetic risk factor for #Alzheimer's, influences the formation of neural circuits during development & changes network synchronicity in the brain.
#neuroskyence 🧪
Thirty years on, our research linking viral infections with Alzheimer’s is finally getting the attention it deserves
#Health #Alzheimers #ColdSoreVirus #HerpesSimplex #Vaccines #DementiaResearch #Neuroscience #Brain #APOE4 #VirusLink #Dementia #Shingles
the-14.com/thirty-years...
