Alt: aerial view of Chicago skyscrapers covered in cloud, with orange to blue sunset colours Credit: Razvan Sera/Amazing Aerial Agency/Science Photo Library

📊 Round up of The Lancet Respiratory Medicine content presented at #SCCM

🏥 Wonderful to see so many advances presented during the congress, continuing progress in #CriticalCare

#ARDS #SEPSIS #BRONCHIOLITIS @sccmcriticalcare.bsky.social

A virus that isn’t COVID or the flu is pummeling Northern California Human metapneumovirus, or HMPV, typically spreads during winter and spring.

A #virus is pummeling Northern #California ...

| #metapneumovirus | #HMPV | #infections | #pathogen | #bronchiolitis | By @arianabindman.bsky.social via @sfgate.com

necessarily involve LRT
- RSV infection in infants frequently causes severe respiratory compromise with #bronchiolitis & #pneumonia, requiring hospitalization or #PICU.
- Most #SARSCoV2) infections in infants are reported to be mild & are typically associated with lower morbidity.

Bronchiolitis: Small Airway Inflammation in Infants- Risk Factors, Symptoms, Diagnosis & Supportive Care
#Bronchiolitis #RSV #PediatricRespiratory #SmallAirways #iPrkashMishra
#Wheezing #Hypoxia #Pediatrics #Pulmonology #NursingNotes #MedNotes

- #Nirsevimab use in the 2023-24 season led to a significant reduction in RSV #bronchiolitis cases in both hospital & ambulatory settings, even with different RSV strains predominating.
- A study in Galicia, 🇪🇸(NIRSE-GAL) found that the benefits of nirsevimab extended beyond 1st year,

Markers of immune dysregulation in pediatric patients with severe #bronchiolitis. New report from Katherine Hickey, Dusan Bogunovic @bogunoviclab.bsky.social and colleagues: rupress.org/jhi/article/...

Children w/ #bronchiolitis exhibit a unique immunophenotype. Hickey, @bogunoviclab.bsky.social et al identify a significant difference in plasmacytoid #DendriticCells & #eosinophils in hospitalized patients, plus differences in cytokines involved in airway #inflammation rupress.org/jhi/article/...

Das Bild ist als Hochformat-Poster gestaltet und besteht aus mehreren klar voneinander abgegrenzten Elementen im Comic-Stil: • Oben befindet sich der Schriftzug „Kombiniere…“ in schwarzer, handschriftlich wirkender Comic-Typografie. • Direkt darunter ist der Oberkörper eines Detektivs im Retro-Cartoon-Stil zu sehen: grüner Hut, kariertes Sakko, Krawatte, Pfeife im Mund und eine Lupe vor dem rechten Auge. Hinter seinem Kopf sind gelbe Strahlen dargestellt, die Aufmerksamkeit oder Erkenntnis symbolisieren. • In der Bildmitte steht eine zentral ausgerichtete, vertikale Liste von Krankheits- und Erregerbezeichnungen in fetter schwarzer Schrift, u. a.: Covid-19, Influenza, Common cold, Chickenpox, Measles, Mumps, Adenovirus, Bocavirus, Rubella, Bronchiolitis, Smallpox, Whooping cough, Diphtheria, Legionella, Meningitis, Tuberculosis und Aspergillosis. • Unten links ist derselbe Detektiv erneut abgebildet, diesmal freudestrahlend mit erhobenem Zeigefinger. In der anderen Hand hält er eine FFP2-Maske, gut erkennbar durch die typische Form und die Aufschrift „FFP2“. Auch hier sind gelbe Strahlen und Glanzsymbole um den Kopf dargestellt, die eine gefundene Lösung symbolisieren. • Unten rechts befindet sich die Illustration eines Luftreinigers in modernem Design. Aus der Oberseite strömen stilisierte blaue Licht- und Luftstrahlen nach oben, ergänzt durch kleine Glanzsymbole. Auf der Front ist ein kleines Display mit einer numerischen Anzeige zu sehen. Der Hintergrund ist vollständig weiß, wodurch Text und Illustrationen klar hervortreten. Insgesamt vermittelt das Bild visuell die Idee, dass durch das Kombinieren von Schutzmaßnahmen – konkret Maske und Luftreiniger – eine Lösung im Umgang mit luftübertragenen Krankheiten dargestellt wird.

A #respiratorMask and #AirPurifier helps prevent all of these👇

#Covid19, #Influenza, #CommonCold, #Chickenpox, #Measles, #Mumps, #Adenovirus, #Bocavirus, #Rubella, #Bronchiolitis, #Smallpox, #WhoopingCough, #Diphteria, #Legionella, #Meningitis, #Tuberculosis, #Aspergillosis

Comparative Efficacy of Continuous Positive Airway Pressure Versus High-Flow Nasal Cannula Therapy in Children With Acute Bronchiolitis: A Systematic Review and Meta-Analysis This systematic review and meta-analysis compared the efficacy of continuous positive airway pressure (CPAP) and high-flow nasal cannula (HFNC) therapy in children with acute bronchiolitis. A comprehe...

RSV season is tough. HFNC is easier to use, but is CPAP more effective? We meta-analyzed 6 RCTs to compare them head-to-head in children with acute bronchiolitis.

doi.org/10.7759/cureus.81826

#WeiPublications #Pediatrics #PICU #MedSky #Bronchiolitis #RSV #FOAMped

Latest Global Burden of Diseases data spotlight significant health disparities in #pneumonia, #bronchiolitis

The highest death rates were in sub-Saharan Africa and in the youngest and oldest people.

www.cidrap.umn.edu/p...

Photo: UN, Albert Gonzalez Farran / Flickr cc

Only 2 days left to join leading #picu experts to explore the practical tools to optimize respiratory management and improve outcomes for infants with severe #bronchiolitis.

Free registration✅: bit.ly/4rS6K40

#espnic #nicu #picu #PediatricCare #ventilation

Join leading #picu experts to explore the practical tools to optimize respiratory management and improve outcomes for infants with severe #bronchiolitis.

Free registration✅: bit.ly/4rS6K40

#espnic #nicu #picu #PediatricCare #ventilation

Bronchiolitis: Symptoms, Causes, and Management Guide - Baby Kids Health Understand bronchiolitis, a common lung infection in infants. Learn about symptoms, causes, and bronchiolitis treatment.

Is That 'Just a Cold' Actually Bronchiolitis? 🚨 A Must-Read for Parents.

www.babykidshealth.com/bronchioliti...

#bronchiolitis #rsv #rsvawareness #babyhealth #pediatrics #infanthealth #parentingtips #momlife #dadlife #sickbaby #wheezing #respiratoryhealth #newmom #newdad #wintervirus #babycold

We consider RSV infections in babies and young children. We explore the seasonality of these infections, along with their symptoms, treatment, and prevention. We hope you can join us!

#pediatric #podcast #RSV #bronchiolitis @nationwidekids bit.ly/4hMc1FQ

🫁 Pediatric Respiratory System
#PediatricRespiratorySystem #PediatricAirway #MedicalNotes #MedicalMindsHub #ChildHealth #RespiratoryCare #Surfactant #Bronchiolitis #VikaasShandily #VikaasLLC

New vaccine for pregnant women protects babies from serious lung infection, study shows Vaccination of pregnant women has been linked to a drop in newborns being admitted to hospital with a serious lung infection, research suggests.

New #vaccine for #pregnant #women protects #babies from serious #lung #infection ...

| #RespiratorySyncytialVirus | #RSV | #virus | #bronchiolitis | By @edinburgh-uni.bsky.social via @sciencex.bsky.social

The challenge of balancing patient respiratory needs w/ floor max settings guidelines is a common one in #bronchiolitis

What are the outcomes when you ⬆️ the floor HFNC max?

Drs. Miller, Jones, & Zorc evaluated these outcomes:
@PedsCareonline
pubmed.ncbi.nlm.nih....

Nirsevimab slashes RSV hospitalizations in infants by 78% in real-world study A Spanish study found that nirsevimab prophylaxis significantly reduced infant hospitalizations, ICU admissions, and severe symptoms linked to RSV and other respiratory viruses. Hospitalizations for R...

Nirsevimab slashes RSV hospitalizations in infants by 78% in real-world study 🇪🇸🧬👶 www.news-medical.net/news/2025050... #RSV #nirsevimab #infanthealth #pediatrics #bronchiolitis #monoclonalantibodies #hospitalization #publichealth #viralprotection #Spain @isirvepi.bsky.social

Multiple #Myeloma Complicated With #Bronchiolitis #Obliterans Syndrome After Allogeneic Haematopoietic Stem Cell Transplantation and Subsequently Underwent #LungTransplantation Successfully: A Case Report

👍Superb #bronchiolitis podcast

Well worth🎧

😁 Taught our 3rd yrs about #Bronchopulmonary #dysplasia (BPD) this week. It was mentioned as a Bronchiolitis #risk #factor

Colleague & I will set up Bronchiolitis #scenarios & incl best practice on assessment: assess from distance & 👶facing parents tum

Final day 🚑 Trust Mandatory Training today

After busy week 👩‍🏫 lecturing at Uni

🎧Listening to latest
@TheResusRoom podcast on
#Bronchiolitis

On my commute in
Its a condition I adore teaching about since CPD sessions with some fab #Paediatric Docs over the years

RSV definitely on the way out...

(but could we have attenuated the peak if we'd have vaccinated more effectively)

#RSV #Bronchiolitis

So bad news for #RSV 2024/25 it's not quite met the dizzy heights of 2019/20...

....great news for everyone working in acute and emergency care though!

#bronchiolitis

Full 2023–24 season results of universal prophylaxis with nirsevimab in Galicia, Spain: the NIRSE-GAL study In April, 2024, we reported on mid-season findings from NIRSE-GAL, a population-based longitudinal study on the effectiveness of universal nirsevimab prophylaxis against respiratory syncytial virus (RSV) in infants aged 0–24 months in Galicia, Spain.1 Our early findings aligned with other interim real-world studies on the considerable effectiveness of nirsevimab in preventing RSV-related hospitalisations for lower respiratory tract infections (LRTIs).2 The immunisation campaign in Galicia (which ran from Sept 25, 2023, to March 31, 2024) is described elsewhere.

#Medsky🧪 #IDsky #pedsky #publichealth This full RSV season analysis confirms that #nirsevimab reduced infant hospitalisation for #RSV-related LRTI, RSV-related LRTI requiring oxygen, and all-cause #bronchiolitis or #bronchitis,

www.thelancet.com/journals/lan...

Respiratory syncytial virus: Understanding the patient journey and healthcare burden | Journal of Family and Child Health Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants in the United Kingdom (UK), contributing to a significant burden of disease for the healthcare system and healthcare professionals (HCPs). To understand how an infant with RSV can impact the various levels of the healthcare system, we explore the patients' and caregivers' experiences through the system using available literature, which was supplemented through interviews with two separate caregivers of infants with a previous diagnosis of RSV disease. In the UK, most infants (~60%) will have experienced an RSV infection by their first birthday. Of these, some will require multiple healthcare encounters, including hospitalisations and admission to paediatric intensive care units. The burden of RSV disease extends beyond the healthcare system, with a substantial impact on the caregivers of affected infants.

#RSV #Bronchiolitis Understanding the impact on babies, families & healthcare www.magonlinelibrary.com/doi/full/10....

Publication in Paediatric Respiratory Reviews: “New paradigms in acute viral bronchiolitis: Is it time to change our approach?”

Abstract: Viral bronchiolitis is the most common pediatric acute respiratory infection leading to hospitalization, and it causes a significant healthcare burden worldwide. Current guidelines recommend supportive management after many clinical trials on specific therapies failed to demonstrate benefits. However, several studies in the past decade have revealed that bronchiolitis may not be a homogeneous disease, but instead may constitute an umbrella comprised of different "endotypes" and "phenotypes" based on patient characteristics, etiology, pathophysiological mechanisms, and clinical presentation. In this extensive review, we summarize the current evidence that several different types of bronchiolitis ("bronchiolitides") coexist, with different short- and long-term consequences on respiratory health and the risk of asthma development. Disease pathobiology, immune response, and clinical characteristics may differ between the two most prevalent viral agents, respiratory syncytial virus and rhinovirus. Recent randomized trials have shown that some subgroups of children may benefit from the use of systemic corticosteroids and/or bronchodilators. These findings also suggest that some children may benefit from individualized therapeutical approaches for viral bronchiolitis rather than following broad recommendations for treating all patients uniformly using only supportive management.

Coincidentally, recently published review making similar points on treatments for the various subtypes/endotypes of #bronchiolitis (written with colleagues Drs Castro-Rodriguez, Astudillo, Puranik, Brown, and Custovic)

doi.org/10.1016/j.pr...

#Pedsky #PedsPulmSky
@ats-peds.bsky.social

Excellent and interesting “umbrella review” of various meta-analysis on the management of #bronchiolitis

Neither implementation nor de-implementation should use blind, one-size-fits-all approaches. Patients are not all the same!!

#Medsky #Pulmsky
@ats-peds.bsky.social
@socpedresearch.bsky.social

Nirsevimab and Hospitalization for RSV Bronchiolitis | NEJM Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis, resulting in 3 million hospitalizations each year worldwide. Nirsevimab is a monoclonal antibody against RSV that has an ext...

which enable its implementation in the general population . #Respiratorysyncytialvirus is a leading cause of #bronchiolitis. #nirsevimab decreased RSV-associated hospitalization by 83%

www.nejm.org/doi/full/10....

#MedSky🧪#IDSky #PedSky #PedsICU In a real-world setting, #nirsevimab therapy was effective in reducing the risk of hospitalized RSV-associated #bronchiolitis. #Nirsevimab is a #monoclonalantibody against RSV that has enhanced neutralizing activity and an extended half-life in vivo,

COVID-19 lockdown reduced childhood wheezing and bronchiolitis cases Bronchiolitis cases dropped significantly during the COVID-19 lockdown, leading to fewer wheezing episodes and reduced respiratory medication use in children.

COVID-19 lockdown reduced childhood wheezing and bronchiolitis cases 👶🌬️🔬 www.news-medical.net/news/2024071... #COVID19 #lockdown #bronchiolitis #RSV #childhealth #pediatrics #wheezing #asthma #publichealth #epidemiology