#SpatialTranscriptomics
Vascular SpatialTime

CD201/PROCR+ 👤perivascular mesenchymal progenitors in artery/vein outer adventitia
Wnt-hi

Hierarchy of adventitial CD34+CD31-CD45-CD146- cell stemness
CD201➡️CD304/NRP1 or CD141/THBD

@nthottappillil.bsky.social #DevCell 2024
www.cell.com/developmenta...

Coordinated control of calcium signaling by CPK3 and CaM2 via CNGCs in response to cold stress in Arabidopsis Calcium (Ca2+) signaling plays a pivotal role in cellular responses to cold stress. Exposure of plant cells to cold water triggers cytosolic Ca2+ elev…

Coordinated control of calcium signaling by CPK3 and CaM2 via CNGCs in response to cold stress in Arabidopsis @cellpress.bsky.social #DevCell

www.sciencedirect.com/science/arti...

#Glioblastoma #CancerNeuroscience #Epigenomics #SingleCell #BrainTumor #DevCell

#SETDB1 #EndogenousRetroVirus

Pax7+ #MuSC, but not Pdgfra+ FAP, SETDB1 KO🐭➡️defected #SkeletalMuscle Regeneration
50%⏬muscle mass

Loss of SETDB1-H3K9me3 in MuSC depresses ERV expression ▶️
⏫cGAC-STING-IRF3▶️
⏬proliferation ⏫cell death ⏫pro-inflamm cytokines

#DevCell 2025
www.cell.com/developmenta...

#SmoothMuscleCell Transcriptomic Atlas🤠

betsholtzlab.org/Publications...

Organotypicity 🫀🫁Colon Aorta

Zonation: A-V, Promixal-Distal Aorta, elastic vs muscular Artery

16 adult🐭 2780 SMC

Notch3➡️vascular SMC
Hhip➡️visceral SMC

#DevCell 2022
www.cell.com/developmenta...

An amino acid-resolution interactome for motile cilia identifies the structure and function of ciliopathy protein complexes Motile cilia are ancient, evolutionarily conserved organelles whose dysfunction underlies motile ciliopathies, a broad class of human diseases. Motile…

An amino acid-resolution interactome for motile cilia identifies the structure and function of ciliopathy protein complexes #DevCell #MassSpec www.sciencedirect.com/science/arti...

Next to my talk (12/16 4 pm room 33B), I will present a poster: "Semaphorin/Plexin Antagonism Orchestrates Collective Cell Migration in vivo". Tuesday, Dec 17 11:15 AM.

P2780/Board No. B397

I am so excited. I just love ASCB meetings!

#cellbio2024 #cellbio #devcell @ascbiology.bsky.social #ASCB

Stem cell migration drives lung repair in living mice Chioccioli et al. establish longitudinal imaging of intact mouse lung tissue ex vivo and in vivo to track the spatiotemporal coordination of alveolar type II cells following bleomycin-induced injury. ...

Watch the AT2 epithelial cell protruding, squeezing, elongating & migrating b/w Alveoli in bleomycin-injured🐭Lung in vivo!!!👹

45% AT2 cells become motile 3-to-6 days post-injury
Video

#DevCell 2024
www.cell.com/developmenta...

Spatially-resolved MultiOmics of🐭fetal #Cardiomyocyte
snRNAseq scATACseq 10X Visium
13 CM subsets
NFYa marks CM4-like subsets

CM NFYa KO🐭->
Embryonic death
#CardiacNoncompaction/Hypertrabeculation
⏬Proliferation
⏬Mitochondrial respiration

#DevCell 2023
www.sciencedirect.com/science/arti...