#tumormicrobiome #hmgb1 #necrosis #adhesion #antibioticresistance #secretion #immuneregulation #LPS #ECM
doi.org/10.1016/j.ch...

MiR-142-3p Regulates ILC1s by Targeting HMGB1 via the NF-κB Pathway in a Mouse Model of Early Pregnancy Loss

miR‑142‑3p regulates #ILC1s by targeting #HMGB1 via the #NFκBpathway, reducing pro‑inflammatory #cytokines and attenuating #MaternalFetal interface #inflammation in mice, highlighting its potential role in #pregnancy‑related disease mechanisms.

#Read: doi.org/10.1007/s115...

The group performed a prospective cohort study on patients with MPE undergoing talc pleurodesis and collected pleural fluid samples before the procedure. They measured biomarkers including, #HMGB1 #protein and #sRAGE, a soluble decoy #receptor that sequesters HMGB1.

GlycoNex Partners with Change Cure to Boost Antibody Program Development GlycoNex has signed a CDMO service agreement with Change Cure to advance their HMGB1-targeted antibody program, marking a significant milestone in drug development.

GlycoNex Partners with Change Cure to Boost Antibody Program Development #Taiwan #New_Taipei_City #GlycoNex #Change_Cure #HMGB1

Hydrogen sulfide (H₂S) ameliorates sepsis-induced brain injury by upregulating heme oxygenase-1 (HO-1) to inhibit high-mobility group box 1 (HMGB1) release The incidence of brain injury in sepsis patients has been as high as 70 %, which has been a significant cause of septic patients' death. However, the pathophysiology of brain injury in sepsis is multi...

Hydrogen sulfide (H₂S) protects the brain from sepsis-induced injury by boosting HO-1 and blocking HMGB1. In mice, H₂S improved survival, cognition, and reduced brain damage - a potential therapy for sepsis-related injury.
#Sepsis #Neuroinflam #H2S #HO1 #HMGB1

Paper 👇

Blood's Aging Broadcast HMGB1 Protein Spreads Senescence Signals, But Reversal Hype Outpaces Human Proof

Extracellular #HMGB1 acts as a "messenger of aging," fostering inflammation and dysfunction in distant organs, a finding that fuels excitement for anti-aging therapies but draws criticism for overpromising based on animal models alone. 🥼

breakingnews4x.com/f/bloods-agi...

Online now - the Review "Intrinsic disorder and fuzzy interactions drive multiple functions of #HMGB1" from Giovanna Musco, Marco Emilio Bianchi, et al.

#FuzzyComplexes #IntrinsicallyDisorderedRegions #Multivalency #MolecularChaperone

authors.elsevier.com/sd/article/S...

MiR-142-3p Regulates ILC1s by Targeting HMGB1 via the NF-κB Pathway in a Mouse Model of Early Pregnancy Loss

This study examines the regulatory effect of miR-142-3p on ILC1s and the underlying mechanism involving #HMGB1 and the NF-κB signaling pathway in early pregnancy loss. #ReproductiveImmunology #medsky

Read: doi.org/10.1007/s115...

"High mobility group box-1 protein–mediated class II major histocompatibility complex transactivator superenhancers are critical for dendritic cell–trained immunity in acute-to-chronic progression of allograft rejection" by Sun et al. doi.org/10.1016/j.aj... #trainedimmunity #HMGB1

Key point: Persistent elevation of HMGB1 post-TBI links to PTE development.
doi.org/10.1002/epi4...

#epilepsy #ILAE #biomarker #cognitiveimpairment #HMGB1 #neuroinflammation #posttraumaticepilepsy #traumaticbraininjury

Inactivated SARS-CoV-2 induces acute skeletal muscle damage in human K18-hACE2 transgenic mice The pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in over 7 million global fatalities and billions of individu…

www.sciencedirect.com/science/arti...

"Significant elevations were noted in inflammatory mediators in the muscle of inactivated #SARSCoV2 mice, including high mobility group box-1, tumor necrosis factor-alpha, phospho-nuclear factor kappa B, caspase 11, and pannexin-1." #HMGB1 #TNFα #NFκB #PANX1