Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF Upstream open reading frames exert translational control of TNFR1, which limits tissue responsiveness to TNF.

I am delighted that our study “Upstream ORFs control TNFR1 abundance and tissue tolerance to TNF”, led by Biao Ma, is published in Science Immunology.

#TNFR1, #inflammation, #CellDeath, #Immunopathology, #Tissue_tolerance
@sic-ucph.bsky.social @ludwigcancer.bsky.social

doi.org/10.1126/scii...

There is still time to register for this #VirtualEvent on Thursday, 2/19! https://bit.ly/3O3nlT5 #WomensHealth #Immunopathology #ChronicIllness

Next week, Dr. Michal Caspi Tal from @mit.edu will discuss IACI's and predictive diagnostics! Don't miss out https://bit.ly/3O3nlT5 #WomensHealth #Immunopathology #ChronicIllness

To kick off our 2026 #VirtualEvents, ASIP Women in Pathology will sponsor a Women's Health Research Seminar featuring Dr. Michal Caspi Tal from @mit.edu! Register here https://bit.ly/3O3nlT5
#WiP #WomensHealth #Immunopathology #ChronicIllness

These speakers at #Pathobiology2026 will spotlight new advances in the biology of specialized pro-resolving mediators, highlighting their dynamic roles in resolving inflammation and more! See the full program at pathobiology2026.asip.org

#Inflammation #Immunopathology #ASIP2026

Image shows a purple square with the cover of the February edition of Pathology Journal, with white writing saying the issue is out now and some of the benefits, including open access articles.

The February issue of #pathologyjournal is out now. Discover the latest peer-reviewed articles on #anatomicalpathology #haematology #immunopathology and more rcpa.me/journal-Feb

- #Immunopathology: Excessive NET formation is a major driver of ARDS & can trigger #thrombosis (🩸 clots) & #autoimmunity. In #COVID , neutrophil activation & NET formation are linked to immunothrombotic clots in the lungs & kidneys, contributing to organ damage & ⏫️ mortality

Organoids in respiratory virus research: advances and perspectives - Molecular Biomedicine The pandemics of respiratory viruses pose a worldwide public health problem and bio-safety threat. Therefore, the development of high-throughput and accurate infection models is crucial for elucidatin...

#Review
Organoids in respiratory virus research: advances and perspectives doi.org/10.1186/s435...

#HumanOrganoid #RespiratoryVirus #Immunopathology #DrugDiscovery

New findings from Idorn, Paludan et al. @au.dk suggest that IFN-I defects lead to elevated levels of HSV-1 replication in the brain, which subsequently enables NF-κB–driven #immunopathology, offering insights with therapeutic potential. rupress.org/jem/article/...

#Immunodeficiency

Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity | Journal of Experimental Medicine | Rockefeller University Press Idorn et al. characterized a mouse strain harboring a mutation identified in an HSE patient. Defective IFN-driven antiviral responses led to hyperactivatio

Type I interferon deficiency redirects antiviral immunity into NF-κB–driven inflammatory pathways, representing a maladaptive compensation that likely underlies the most common forms of virus-induced #immunopathology.

#immunology
#immunity
#virus

buff.ly/bbxWAwN

Drs Fran Prenen & Philippe Van den Steen review #malaria-associated #liver #dysfunction: a forgotten challenge. #Immunopathology #MALID

authors.elsevier.com/a/1lDKu5Eb1x...

Immunopathology in human tuberculosis The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

@tomscriba.bsky.social, Mahlatse Maseeme, Carly Young, Laura Taylor, & Alasdair Leslie review the #immunopathology of #tuberculosis! #TB

Immunopathology in human tuberculosis The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

@tomscriba.bsky.social, Mahlatse Maseeme, Carly Young, Laura Taylor, and Alasdair J. Leslie review our current understanding of the #immunopathology of #tuberculosis! #TB

Clinical manifestations of and organ-specific pathologies of TB in humans. (A) Extrapulmonary TB. (B) Primary and postprimary pulmonary TB.CREDIT: A. MASTIN/SCIENCE IMMUNOLOGY

Review looks at #immunopathology in #tuberculosis. @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

Immunopathology in human tuberculosis The balance between protective and pathological immune responses shapes progression of Mycobacterium tuberculosis infection.

This week in #Science #Immunology: @tomscriba.bsky.social, Mahlatse Maseeme, Carly Young, Laura Taylor, & Alasdair Leslie, five researchers based in #SouthAfrica, pen a landmark #review on the #immunopathology of #tuberculosis !

SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair antibody-dependent complement-mediated lysis The complement system is a vital anti-microbial defence mechanism against circulating pathogens. Excessive complement activation can have deleterious outcomes for the host and is consequently tight...

#MedSky🧪#IDSky #Immunology The findings present an intriguing immune escape mechanism that provides novel insights into the #immunopathology observed in severe #COVID19

www.tandfonline.com/doi/full/10....

#MedSky🧪#IDSky #NeuroSky imbalances among TH cell subsets can contribute to the #immunopathology of severe diseases such as allergies, autoimmunity and infectious diseases. In #SARSCoV2 infection , #LongCovid / #NeuroCovid is correlated with elevated interferon responses,

https://www.iamascientist.info/tina-cheng#here

ICB
Persist or Perish:
Can #Bats Threatened with #Extinction Persist and Recover from White-nose Syndrome?
Cheng, Bennett, O'Mara, Auteri, Frick
doi.org/10.1093/icb/...
& stay tuned Tuesday for the blog on co author Dr.
Tina L. Cheng.
#fungal #conservation #immunopathology

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MedSky🧪#IDSky Severe #COVID19 is marked by excessive inflammation that can persist after infection. The commensal yeast #Candidaalbicans is now implicated in the acute and chronic #immunopathology of #LongCOVID