Promotional graphic for the StudyME Registry. The background shows blurred researchers working in a lab. Text on a white banner at the bottom reads: “Do you want to help speed up the research process? Now you can! Join the OMF StudyME Registry: www.omf.ngo/studyme.”

🔬Help advance #MECFS and #LongCOVID research by joining OMF’s StudyME, a free global participant registry that connects you with researchers conducting studies in these areas.

👉 Sign up today: https://www.omf.ngo/studyme/

#UnitedForME #MECFSresearch #POTS #pwME #pwLC

#TheNicotineTest #MECFS #LongCovid #PASC #MECFSResearch #MEResearch #LongCovidResearch #PASCResearch #FundMECFS #FundLongCovid #Vielight #RedLightTherapy #Rutin #HRV #HeartRateVariability #PEM #GIP #PostPrandial #MedicalResearch #PatientLed #PatientLedResearch #FundMedicalResearch

Update: UK ME/CFS Biobank Steering Group - The ME Association The ME Association (MEA) has invested £1.095m in the UK […]

Update: UK ME/CFS Biobank Steering Group

The Cure ME Steering Group meets quarterly to discuss matters relating to the UK ME/CFS Biobank,  and its most recent meeting was on 17 December.

Read more about this meeting: https://meassociation.org.uk/4wug 

#MECFS #CureME #UKMECFSBiobank #MECFSResearch

£1.1m awarded to investigate links between ME/CFS and Long Covid A new landmark study funded by The ME Association will help scientists to uncover shared pathways between ME/CFS and Long Covid.

Imperial College London: £1.1m awarded to investigate links between ME/CFS and Long Covid

"A new landmark study funded by The ME Association will help scientists to uncover shared pathways between ME/CFS and Long Covid."

https://tinyurl.com/mr3ybhwv

#MECFSResearch #MECFS #pwME #LongCovid

Graphic with the StudyME logo, showing a blue interconnected globe and the text ‘Accelerate Research – Join OMF StudyME Registry,’ along with the OMF logo in the corner.

🔬Help advance #MECFS and #LongCOVID research by joining OMF’s StudyME, a free global participant registry that connects you with researchers conducting studies in these areas. Healthy volunteers are needed too!

👉 Sign up today: www.omf.ngo/studyme/

#UnitedForME #MECFSresearch #POTS #pwME #pwLC

A huge thank you to the scouts from Essen-Horst! 🙌
Their charity run raised an incredible €21,100 for #mecfsresearch .
You can start your own campaign too – every initiative counts!
Info: 👉 https://mecfs-research.org/en/support/
#research #LongCovid #PostCovid #mecfs

Im Fundraising-Shop der ME/CFS-Forschungsstiftung werden Weihnachtskarten angeboten, die direkt an Familie, Freund*innen oder Kolleg*innen versendet werden können, um so die Stiftung sichtbar zu machen.

Im Bild ist eine Liste mit Elementen, die im Spendenpaket für die Fundraising-Aktion enthalten sind, wie hochwertige Weihnachtskarten, festliches Design mit ME/CFS-Logo, ein Premium-Umschlag in Creme und ein Informationsflyer über ME/CFS und die Forschung.

Unsere Weihnachtskarten sind da! 🎄💙 Verschicke persönliche Grüße und mach zugleich auf #mecfs aufmerksam: Jede Karte enthält einen Info-Flyer + QR-Code zum direkten Spenden.
Hochwertige Karte, Premium-Umschlag, echter Impact. #mecfsresearch #mecfsforschung #LongCovid #PostCovid

a man standing in front of a blue background

a blue oval with white text

Big step for people with #mecfs & #LongCovid in Germany: the BMFTR announces a “National Decade on Post-Infectious Diseases” with long-term research funding and a focus on diagnostics & treatments. #mecfsresearch #research

ein blaues Oval mit weißem Text

Wichtiger Tag für Menschen mit #mecfs & #LongCovid : Die BMFTR​ kündigt eine „Nationale Dekade gegen postinfektiöse Erkrankungen“ an, mit langfristiger Forschungsförderung und Fokus auf Diagnostik & Therapien.
#mecfsresearch #mecfsforschung #research #forschung

✨ The time has come: our online shop for fundraisers is now live.
What can you expect to find there? Take a look for yourself. 🔗: https://t.ly/merf-fundraising #mecfsresearch #mecfsforschung #research #forschung #LongCovid #PostCovid #mecfs #fundraising

✨ Es ist soweit: Unser Online-Shop für Spendenaktionen ist live.
Was euch dort erwartet? Schaut selbst. 🔗: https://t.ly/merf-fundraising #mecfsresearch #mecfsforschung #research #forschung #LongCovid #PostCovid #mecfs #fundraising

🌍 People worldwide used their limited energy to finish “ME/CFS is…” Their voices show the challenges, losses & urgent need for change. Thanks to matching donors, every gift to OMF is tripled up to $500K!

👉 Donate: www.omf.ngo?form=donate-....

#mecfs #pwME #mecfsresearch

David Tuller interviews Professor Chris Ponting about the new PRIME research project into ME/CFS, which is being conducted by the University of Edinburgh.

https://www.youtube.com/watch?app=desktop&v=1dgKMO0tPBw

#pwME #MECFS #MyalgicEncephalomyelitis #MECFSResearch

Join the #ausmebiobank in advancing #MECFS and #longCOVID research.
If you're in QLD, NSW or VIC with these conditions, or a healthy volunteer, donate blood today.
Find out more 👉 zurl.co/kSU0r


#MECFSResearch #DonateForScience #MedicalResearch #ThankYouDonors

5/
Oops, I forgot to say it was in the Spring 2024 edition www.meresearch.org.uk/wp-content/u...

#MEresearch #MECFSresearch

Haptoglobin phenotypes and structural variants associate with post-exertional malaise and cognitive dysfunction in myalgic encephalomyelitis - Journal of Translational Medicine Background Myalgic encephalomyelitis (ME) is a chronic, multisystem illness characterized by post-exertional malaise (PEM) and cognitive dysfunction, yet the molecular mechanisms driving these hallmark symptoms remain unclear. This study investigated haptoglobin (Hp) as a potential biomarker of PEM severity and cognitive impairment in ME, with a focus on Hp phenotypes and structural proteoforms. Methods A longitudinal case–control study was conducted in 140 ME patients and 44 matched sedentary healthy controls. In the discovery phase, global plasma proteomic profiling was performed in 61 ME patients and 20 controls before and after a standardized, non-invasive stress protocol in order to induce PEM. Associations between Hp levels, phenotype, and cognitive performance were assessed. In the validation phase, plasma Hp concentrations and proteoform composition were analyzed in an independent cohort of 89 ME patients and 24 controls using high-performance liquid chromatography (HPLC). Results ME patients demonstrated a significant reduction in Hp levels following post-exertional stress. Lower baseline Hp concentrations were associated with impaired cognitive performance. Hp phenotypes were differentially associated with symptom burden, with the Hp2-1 phenotype enriched in ME and linked to greater PEM severity and cognitive deficits compared to Hp1-1 and Hp2-2. HPLC analysis revealed altered Hp proteoform profiles in the Hp2-1 subgroup, including increased high-mass tetrameric and pentameric forms and shorter retention times indicative of structural changes. In contrast, the Hp1-1 phenotype was associated with milder symptoms and greater cognitive resilience. Conclusions These findings suggest that Hp phenotype and proteoform structure modulate the physiological response to post-exertion in ME, offering insight into the molecular basis of PEM and its clinical heterogeneity. Hp may serve as a translational biomarker for patient stratification and a potential therapeutic target to mitigate oxidative stress and cognitive dysfunction in ME.

New study finds that genetic differences in a blood protein may explain why people with ME experience severe crashes and brain fog after exertion.

https://tinyurl.com/467wec2a

#MECFS #MECFSResearch #MEResearch #PEM #MyalgicEncephalomyelitis

Kara Jane karajanesings.com Help Kara Jane Spencer raise money to support ME Association

Donate here: https://www.justgiving.com/page/kara-jane-sings-2  

#KaraJaneSings #InLimbo #MECFS #MECFSResearch

ME/CFS Research Foundation

Wir freuen uns sehr, dass Elena mit an Bord ist! 🙏
Habt ihr Fragen an sie? Schreibt sie gerne in die Kommentare! 💬"

mecfs-research.org
_______
#MECFS #MECFSResearch #Meettheteam #Team

3/3

ME/CFS and PASC Patient-Derived Immunoglobulin Complexes Disrupt Mitochondrial Function and Alter Inflammatory Marker Secretion
Basens, E. E., Bellmann, J. et al.
Paper
Details
#MECFSResearch #PASCStudy #ImmunoglobulinComplexes

Hello Selina We are writing to let you know that the initial DNA results from the DecodeME study will be available in the next few days. We plan to send you an email with our findings on Wednesday 6th August around 7pm. We will also be announcing the results on our website at this time. We're letting you know the timing in advance so you can pace yourself if needed. Thank you for your continued support and we look forward to sharing more very soon. Warmest wishes, The DecodeME Team

So many of us in the UK #mecfs community, who took part in this DNA analysis study, will be checking our emails on Wednesday night...

#DecodeME #mecfsresearch #DNAresearch

Calling #MECFS researchers: It’s your last chance to apply for free biosamples from the UK ME/CFS Biobank for your #MECFSResearch

Deadline: today at 23.59

How to apply: http://bit.ly/MECFS-samples

#pwME #MyalgicE

IMAGE DESCRIPTION: Wording - The UK ME/CFS Biobank is offering free samples to support ME/CFS researchers. LSHTM and Cure ME Logos.

The UK ME/CFS Biobank are offering free #MECFS samples to researchers until this Thursday 

Samples are provided extensive patient profiles and comprehensive datasets to facilitate the next breakthroughs in ME/CFS research

Details: http://bit.ly/MECFS-samples

#pwME #MECFSResearch #Research

ME/CFS: Lauterbach fordert mehr Forschung zu Chronischem Fatigue-Syndrom Ex-Gesundheitsminister Karl Lauterbach wirft der Bundesregierung "Staatsversagen" bei der Erforschung der Krankheit ME/CFS vor. Er fordert eine Milliardeninvestition.

"Former [German] Health Minister Karl Lauterbach accuses the German government of "government failure" in researching ME/CFS. He calls for a billion-dollar investment." 

Read more: https://tinyurl.com/ymmht4yw

#pwME #MECFS #MyalgicEncephalomyelitis #MECFSResearch

IMAGE DESCRIPTION: Heading - The UK ME/CFS Biobank provides samples with a rich set of clinical, immunological and demographic data. LSHTM and Cure ME Logos.

For years, we've been proud to support the work of the UK ME/CFS Biobank.

And we're happy to share their latest campaign that opens up free samples to support the next generation of biomedical research tackling #MECFS

Apply by 31 July: https://tinyurl.com/mp96zzwp

#pwME #MECFSResearch

IMAGE DESCRIPTION: IMAGE DESCRIPTION: Photo of an MRS machine. Wording reads: Molecular Psychiatry: Brain and muscle chemistry in myalgic encephalitis/chronic fatigue syndrome (ME/CFS) and long COVID: a 7T magnetic resonance spectroscopy study. MEA logo bottom right.

On 12th July, a new study was published which provides further evidence of mitochondrial dysfunction and abnormal lactic acid production in ME/CFS.

https://meassociation.org.uk/ptxrv 

#MECFS #pwME #MyalgicEncephalomyelitis #MECFSResearch #Mitochondria #LacticAcid

Research: SMPDL3B a novel biomarker and therapeutic target in ME - The ME Association On the 7th July, a research paper entitled ‘SMPDL3B a […]

"Sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B) is emerging as a potential biomarker and therapeutic target in myalgic encephalomyelitis (ME)" 

Read more, and Dr Shepherd's, Hon. Medical Adviser to the MEA's, comments here: https://meassociation.org.uk/wgce 

#MECFS #pwME #MECFSResearch

IMAGE DESCRIPTION: Heading - The UK ME/CFS Biobank is offering free samples to support ME/CFS researchers. Graphics of Cure ME and London School of Hygiene and Tropical Medicine logos.

The UK ME/CFS Biobank have sent #MECFS samples around the world to researchers working on the next important breakthroughs.

Join this global effort by applying for some of the biobanks free ME/CFS samples, available until the end of this month.

Details: bit.ly/MECFS-samples

#MECFSResearch #pwME

Gut microbiome: A new frontier for chronic fatigue and long COVID management Imagine living with a persistent, debilitating fatigue that no amount of rest can alleviate, coupled with a constellation of other symptoms such as brain fog, pain, and sleep disturbances. This is the reality for millions suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Now, envision a similar struggle following a viral infection, a condition increasingly recognized as long COVID.

Medical Xpress: Gut microbiome: A new frontier for chronic fatigue and long COVID management

https://tinyurl.com/bderd8yw

#MECFS #pwME #LongCovid #PostCovidSyndrome #GutMicrobiome #MECFSResearch #LongCovidResearch

IMAGE DESCRIPTION: Green background with the CureME and London School of Hygiene and Tropical Medicine logos at the bottom right. Wording reads: The UK Me/CSF Biobank provides samples with a rich set of clinical, immunological, and demographic data.

The MEA are proud to support the CureME Team, who are currently offering free, high-quality biosamples from the UK ME/CFS Biobank.

Make sure you apply by 31 July: http://bit.ly/MECFS-samples 

#MECFS #MEResearch #MECFSResearch #CureME

@mecfsresearch.bsky.social :

"Wir feiern die Eröffnung der neuen ME/CFS und Post-COVID-Modell-Station in Haus 10 der München Klinik Schwabing! 🏥🎈

Die ME/CFS Research Foundation ist (...) ein wichtiger Co-Finanzierungspartner.
Koordiniert wird das Projekt von Prof. Dr. Uta Behrends."
#MEcfsResearch