TET1: The epigenetic architect of clinical disease progression
This review highlights #TET1 as a key #DNAdemethylation regulator that maintains epigenetic balance and modulates #TumorSuppressor genes, with context-dependent roles in #cancer progression, acting as both tumor suppressor & #oncogenic factor.
#OpenAccess: doi.org/10.1016/j.ge...
ZNF750 functions as a #TumorSuppressor in #ESCC by regulating #PUFA metabolism via FADS1, and its loss drives lipid remodeling, malignant progression, and #ferroptosis sensitivity through ACSL4, spotlighting PUFA metabolism and ferroptosis as targets.
Read: doi.org/10.1016/j.ge...
🆕 ADVANCE ONLINE 🆕
CANCER METABOLISM REVIEW: Metabolic permissiveness: how tissue context shapes cancer
By Chrysanthi Moschandrea and Christian Frezza
➡️ genesdev.cshlp.org/content/early/2026/02/09...
#cancermetabolism #oncogene #tumorsuppressor #mutation #TCAcycle
Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer: Integrating Bioinformatics Analysis with Experimental Confirmation
Bioinformatic and experimental analyses reveal #SLC9A2 as a #TumorSuppressor in #ColorectalCancer, inhibiting proliferation and metastasis via #MAPK signaling, highlighting its potential as a diagnostic and therapeutic target.
Read: doi.org/10.1007/s115...
ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/β-Catenin Signaling Pathway
ZNF554 functions as a #TumorSuppressor in UCEC, inhibiting its progression by regulating the RBM5/WNT/beta-catenin signaling pathway, thus highlighting it as both a prognostic #Biomarker and a #TherapeuticTarget for UCEC.
Read: doi.org/10.1007/s115...
Scientists identify #OXCT1 as a #TumorSuppressor in #ColorectalLiverMetastasis, where its loss drives migration and #metastasis via CDK8–Wnt/β‑catenin signaling; low OXCT1 correlates with poor outcomes, highlighting therapeutic potential.
#OpenAccess: doi.org/10.1016/j.ge...
Multiplexed CRISPR/Cas9 Editing of Tumor Suppressor Genes Recapitulates Molecular and Morphological Features of High-Risk Endometrial Cancer
Bonifaci, N. et al.
Paper
Details
#CRISPR #EndometrialCancer #TumorSuppressor
The LTFe–LTF #enhancerRNA axis is identified as a #ferroptosis-promoting #TumorSuppressor in #ProstateCancer, with AR signaling disrupting LTFe-mediated chromatin looping, and #enzalutamide + RSL3 suppresses #CRPC growth.
#OpenAccess in #STTT: doi.org/10.1038/s413...
This study identifies psiTPTE22-HERV as a #TumorSuppressor that inhibits the #PI3K/AKT/#mTOR/#EIF4E pathway, with its down-regulation serving as an independent marker of poor prognosis in #GastricCancer patients. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
🔬 Two full-time #Postdoc Associate Scientist positions are available in the laboratory of Zuzana Keckesova—which aims to identify new #tumorsuppressor pathways.
See more ► www.uochb.cz/en/open-posi... ⤵️
#openposition #iocbprague #iocb #researchjobs #tumorsuppressors #cancer #cancerresearch
Targeting an Enzyme Could Rewire Cancer Cells to Suppress Growth by up to 77% for Melanoma and Colorectal Tumors: Eleven years of cancer research has proven fruitful for a scientist at Johns Hopkins… @goodnewsnetwork.org #CancerResearch #Melanoma #ColorectalCancer #TumorSuppressor #HealthInnovation
This study reveals that #SLC9A2 acts as a #TumorSuppressor through the #MAPKpathway and may be a potential target for #ColorectalCancer (CRC) diagnosis, prognosis and #therapy. #bioinformaticanalysis #biomarkers #MostDownloaded #medsky
Read: link.springer.com/article/10.1...
Insights into targeting LKB1 in tumorigenesis
This review from @westernu.bsky.social highlights the biochemical processes dictating liver kinase B1 (LKB1) activity in cell biology and pathology and addresses the therapeutic relevancy of targeting LKB1 in #cancer. #Tumorsuppressor
#OpenAccess: https://buff.ly/4hbX4Mg
