#Medsky🧪 #IDsky #microsky #immunosky #publichealth The findings highlight the gut-immune interface as a potential driver of #Longcovid & support therapeutic strategies targeting #viralpersistence and intestinal immune homeostasis

WAIT, COVID is still in the body 3 YEARS later?! 🤯 New study sees viral remnants and T-cells hiding in major organs. Long COVID breakthrough! It validates SO much. If you have Long COVID, share this! 👇🦠🔬

#LongCOVID #COVID19 #ScienceNews #ViralPersistence

Covid is endemic.*

*in your testes and dick

#ViralPersistence

decline in effector memory T cells lasting over a year in #postcovid / #PACS
2. #Viralpersistence in tissues may contribute to long immune remodeling, similar to what is seen in viral infections.
3. Immune Dysregulation - Persistent low levels of lymphocytes

🔑 findings
- Mechanism of Deficits: Infection restricted to the respiratory tract was found to trigger long term loss of dopaminergic neurons in the olfactory bulb & substantia nigra. These deficits were not caused by #viralpersistence in the 🧠

#ApresJ20 #LongCovidBelgium
#CovidLongEnfants #SantéPublique
#PatientsExperts #MaladiesPostInfectieuses
#DroitsDesPatients #CovidLong
#LongCovid #Science
#Recherche #Santé #PostCovid
#EM #EncéphalomyéliteMyalgique
#Microclots #ViralPersistence
#Immunologie #Immunité

reports that #viralpersistence in contributes to long-term immune remodeling, similar to chronic viral infections. This may impair the immune system's ability to mount effective responses against latent infections.

Frontiers | Consensus based recommendations for the management of post-COVID long-term sequelae (Long COVID): a regional perspective Background and objectiveThe coronavirus disease 2019 (COVID-19) pandemic marks the biggest public health emergency of the 21st century. The long-term health ...

- Vaccination reduces the number of #Covid infections and the severity of acute illness, which may minimize virus-induced pathology & #viralpersistence , thereby ⏬️ the risk of LC

www.frontiersin.org/journals/med...

@nature.com
www.nature.com/articles/s41...

#ApresJ20 #CovidLong #LongCovid
#EncéphalomyéliteMyalgique #EM #MECFS #Lyme #Alzheimer
#PostInfectious #PersistentVirus #ViralPersistence #IACCs #PostInfectieux #BiomedicalResearch #ClinicalTrials #FallSymposium2025 #PolyBio #UCSF #Karolinska #MountSinai #DemystifyingLongCovid

#Medsky🧪 #IDsky #immunosky #publichealth @petterbrodin.bsky.social , @casanovalab.bsky.social et al
To determine the underlying genetic causes & other modifying factors like sex hormones , interferon responses impacting restrained #Tcell responses to #SARSCoV2 & #viralpersistence in #LongCOVID.

the presence of persistent S protein ( #Viralpersistence ) in the etiology of this chronic disease.
journals.asm.org/doi/10.1128/...
- The RGD (arginine-glycine-aspartic acid) sequence in the Spike protein's receptor-binding domain (RBD) functions as a ligand for integrin receptors,

#Medsky🧪 #IDSky #immunosky #publichealth Recap This excellent study @casanovalab.bsky.social @petterbrodin.bsky.social et al identified that a "restrained" or underperforming memory CD8+ T cell response appears to enable #viralpersistence & stimulate heightened IgG antibody production

but instead involves a Neuropilin-1-dependent mechanism.
www.sciencedirect.com/science/arti...
@plos.org
journals.plos.org/plospathogen...
Emerging evidence suggests that #viralpersistence, or the presence of viral components, may be a potential driver of #LongCOVID symptoms .

Pp1ab [peptide] is encoded by the ORF1ab gene and plays a crucial role in SARS-CoV-2 viral RNA transcription and replication. The Pp1ab viral protein persisted in EVs months after acute infection and may serve as a blood-based biomarker for LongCOVID

#Medsky 🧪 #IDSky #Immunosky #publichealth
The intriguing role of #extracellularvesicles in mediating #SARSCoV2 effects & potential #LongCOVID
The study highlights the dual role EVs in #covid infection: they can facilitate #viralpersistence & contribute to LC
link.springer.com/article/10.1...

The circulation of infected megakaryocytes & platelets could also serve as a potential route for viral spread within the body. #Viralpersistence as a direct cause of LC is supported by research that closely associates “loss of taste/altered taste” with #Viralpersistence in the taste buds of 👅 …

Evidence for #viralpersistence in #Longcovid
A growing body of evidence suggests that the persistent presence of #SARSCoV2 in various cell types & tissues may be the underlying cause of #LongCOVID sequelae While many individuals with #viralclearance from their throats within 28 days,

Targeting the SARS-CoV-2 reservoir in long COVID There are no approved treatments for post-COVID-19 condition (also known as long COVID), a debilitating disease state following SARS-CoV-2 infection t…

#covid
#longcovid
#viralpersistence
#science

Viral Persistence / Long Covid Action Project | Patrick Farnsworth Get more from Patrick Farnsworth on Patreon

Now available to all members (free and paid), my interview w/ @joshuapribanic.bsky.social @amymitchellart.bsky.social, discussing #LongCovid, #viralpersistence, & the groundbreaking new @lcap.bsky.social book, A National Treatment and Research Agenda for Long Covid.

www.patreon.com/posts/viral-...

In 2020, a bioweapon was released mildly into your testes.

#CovidLivesInYourDick
#ViralPersistence

“There is a very strong connection between #SarsCov2 persistence in patients with #LongCovid and the persistence of related other RNA viruses, [the #enteroviruses], in patients with an #MECFS diagnosis who got sick before the Covid pandemic.”

#ViralPersistence

Why Covid persistently living in my dick was the CHRISTMAS GIFT I Didn’t Know I Needed

#ViralPersistence

#COVID19 #ViralPersistence #ReplicatingVirus #LongCOVID

#MedSky🧪 #IDsky #Immunosky It’s a terrific 🧵 on #Viralpersistence 👇🏿👇🏿👇🏿

Coronavirus Tidbits #323, December 1, 2024 – Dr. Judy Stone

New free #Coronavirus Tidbits Newsletter is up, w clips abt #LongCovid #ViralPersistence #AvianFlu, Surviving Hospitalization, #MaskBans, and more--

and by @tylerblack.bsky.social @zey.bsky.social @broadwaybabyto.bsky.social , more

drjudystone.com/coronavirus-...

Long COVID: A proposed hypothesis-driven model of viral persistence for the pathophysiology of the syndrome Long COVID (coronavirus disease 2019) syndrome includes a group of patients who, after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibit lingering mild-to-moderate s...

🧠 pmc.ncbi.nlm.nih.gov/articles/PMC...
🧠 www.nature.com/articles/s41...
In a recent study, a significant association between #viralpersistence & the presence of LC symptoms noted & and neutrophils appear to play a role
www.thelancet.com/pdfs/journal...

link.springer.com/content/pdf/...

Persistent SARS-CoV-2 infection: significance and implications The study "Persistent SARS-CoV-2 infection: significance and implications" delves into the complexities and challenges posed by prolonged SARS-CoV-2 infections, especially in immunocompromised individ...

Persistent SARS-CoV-2 infection: What does it mean for long COVID and global health? Explore the science and implications behind lingering viral presence.

Read more 👉 longcovidresource.com/persistent-s...

#LongCOVID #COVID19 #ViralPersistence

The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China Our findings suggest that residual SARS-CoV-2 can persist in patients who have recovered from mild COVID-19 and that there is a significant association between viral persistence and long COVID symptom...

and that there is a significant association between #viralpersistence & #longCOVID symptoms.
🦠 www.thelancet.com/journals/lan...
🦠 www.nature.com/articles/s41...
🦠 www.mdpi.com/1999-4915/16...
🦠 virologyj.biomedcentral.com/articles/10....
🦠 assets-eu.researchsquare.com/files/rs-429...

When you keep stimulating a T cell with the same virus over and over again, a strange thing happens. The T cell decides it's just going to live with the damn thing. When you see markers like PD-1 and Tim3 that means #ViralPersistence David Price MD PhD

Nirmatrelvir plus ritonavir reduces COVID-19 hospitalization and prevents long COVID in adult outpatients - Scientific Reports Scientific Reports - Nirmatrelvir plus ritonavir reduces COVID-19 hospitalization and prevents long COVID in adult outpatients

This effect is likely due to the relationship between #viralpersistence and long COVID symptoms , as treatment may reduce #viralload & subsequently, #longCOVID symptoms.

www.nature.com/articles/s41...

Thread by @ejustin46 on Thread Reader App @ejustin46: 𝙇𝙊𝙉𝙂 𝘾𝙊𝙑𝙄𝘿 𝙍𝙄𝙎𝙆𝙎 𝙖𝙣𝙙 𝙑𝙄𝙍𝘼𝙇 𝙋𝙀𝙍𝙎𝙄𝙎𝙏𝙀𝙉𝘾𝙀 (5𝘵𝘩 𝘢𝘯𝘥 𝘭𝘢𝘴𝘵 𝘱𝘢𝘳𝘵) "𝙕𝙤𝙢𝙗𝙞𝙚" 𝙫𝙞𝙧𝙪𝙨 𝙛𝙧𝙖𝙜𝙢𝙚𝙣𝙩𝙨 𝘸𝘩𝘪𝘤𝘩 𝘤𝘰𝘯𝘵𝘪𝘯𝘶𝘦 𝘵𝘰 𝘤𝘢𝘶𝘴𝘦 𝘪𝘯𝘧𝘭𝘢𝘮𝘮𝘢𝘵𝘪𝘰𝘯 𝘢𝘧𝘵𝘦𝘳 𝘵𝘩𝘦 𝘷𝘪𝘳𝘶𝘴 𝘪𝘴 𝘥𝘦𝘴𝘵𝘳𝘰𝘺𝘦𝘥 2) According to our opinion, one of th...

Another 🧵 from @ejustin46.bsky.social on ""𝙕𝙤𝙢𝙗𝙞𝙚" 𝙫𝙞𝙧𝙪𝙨 𝙛𝙧𝙖𝙜𝙢𝙚𝙣𝙩𝙨 𝘸𝘩𝘪𝘤𝘩 𝘤𝘰𝘯𝘵𝘪𝘯𝘶𝘦 𝘵𝘰 𝘤𝘢𝘶𝘴𝘦 𝘪𝘯𝘧𝘭𝘢𝘮𝘮𝘢𝘵𝘪𝘰𝘯 𝘢𝘧𝘵𝘦𝘳 𝘵𝘩𝘦 𝘷𝘪𝘳𝘶𝘴 𝘪𝘴 𝘥𝘦𝘴𝘵𝘳𝘰𝘺𝘦𝘥"

threadreaderapp.com/thread/18072...

#LongCovid #ViralPersistence