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Posts by Leiden Early Drug Discovery & Development (LED3)

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In this Nature article https://lnkd.in/eQsGRRvC they report N-destethylfluoronitazene (DFNZ) as a promising opioid receptor superagonist analgesic with minimal adverse effects (in Mice). Mind you… | S... In this Nature article https://lnkd.in/eQsGRRvC they report N-destethylfluoronitazene (DFNZ) as a promising opioid receptor superagonist analgesic with minimal adverse effects (in Mice). Mind you, the...

Other examples:

www.linkedin.com/posts/stan-v...

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(3/4)

1 week ago 2 1 1 0
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How did the Medicinal Chemists in my department at Organon create the new chemical entity that is now marketed as acalabrutinib (Calquence), a blockbuster BTK inhibitor? Initially, there was no BTK… |... How did the Medicinal Chemists in my department at Organon create the new chemical entity that is now marketed as acalabrutinib (Calquence), a blockbuster BTK inhibitor? Initially, there was no BTK pr...

He covers a variety of drug discovery stories with insightful science and a lot of interesting background.

Make sure to check them out and follow him, if you are interested. (2/4)

www.linkedin.com/posts/stan-v...

1 week ago 1 1 1 0
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Another example—this time from my own history—of incremental improvement in drug discovery. In 1988 it was discovered in Oxford that deoxynojirimycin (DNM), an α‑glucosidase inhibitor found in… | Stan... Another example—this time from my own history—of incremental improvement in drug discovery. In 1988 it was discovered in Oxford that deoxynojirimycin (DNM), an α‑glucosidase inhibitor found in mulberr...

Do you want to hear the exciting and insightful stories behind drug discovery?

Lately, Stan Van Boeckel, emeritus professor at @leidenscience.bsky.social and @led3hub.bsky.social , has started a series of #SciComm posts on this topic. (1/4)

www.linkedin.com/posts/stan-v...

1 week ago 8 3 1 0
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Are you a #PhD or #Postdoc and do you want to present your #ChemBio research to a wide international audience?

Here is your chance! Enter our Abstract Challenge to win a Flash Talk at the 6th Virtual ChemBioTalks on September 29th. (1/2)

chemistry-europe.onlinelibrary.wiley.com/hub/journal/...

2 weeks ago 3 2 2 0
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I am very excited that we will again have three slots for Flash Talks by #PhDs and #Postdocs at the 6th Virtual @chembiotalks.bsky.social!

If you are interested in applying, enter our abstract challenge: fd24.formdesk.com/universiteit...
#ChemBio #ChemSky #Presentation #Networking #Award

2 weeks ago 5 3 0 1
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We are very excited that Ed Tate will be one of our speakers at the 15th International Activity-Based Protein Profiling Meeting #ABPP2027 (June 2nd to 4th, 2027) in Leiden.

If you do not want to miss anything, make sure to follow us and to sign up for our mailing list: www.universiteitleid...

2 weeks ago 2 2 0 0

We have another great @led3hub.bsky.social Lecture lined up for you!

On April 23rd, Peng Chen will visit Leiden and report on his group's exciting research into protein chemistry in living cells.

If you are interested, do not miss it!

#ChemSky #ChemBio

2 weeks ago 3 1 0 0
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We are looking forward to the LED3 Lecture by Peng Chen on April 23rd. He will talk about "Live-cell Protein Chemistry in Health and Disease"

If you are interested, make sure to come by!

www.universiteitleiden.nl/en/science/l...

#ChemBio #ChemSky #DrugDiscovery

2 weeks ago 1 1 0 1
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We are excited that Matt Bogyo from Stanford will be one of our speakers at the 15th International Activity-Based Protein Profiling Meeting #ABPP2027 (June 2nd to 4th, 2027) in Leiden.

If you do not want to miss anything, follow us and sign up for our mailing list: www.universiteitleid...

3 weeks ago 2 2 0 0
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How can we develop new antibiotics against the most devastating infections with antibiotic-resistant Gram-negative bacteria?

Thomas Clairfeuille gave an inspiring lecture on this topic in his @led3hub.bsky.social Lecture. (1/8)

www.nature.com/articles/s41...

3 weeks ago 8 1 1 0
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We are very happy that Thomas Clairfeuille from Roche visited us today for a very well attended LED3 Lecture. He talked about "The discovery and mechanism of lipid transport inhibition by the antibiotic Zosurabalpin".

www.nature.com/articles/s41...
#Antibiotics #DrugDiscovery #ChemBio #ChemSky

3 weeks ago 2 1 1 0
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We are excited that Benjamin Cravatt from @scripps.edu will be one of our speakers at the 15th International Activity-Based Protein Profiling Meeting #ABPP2027 (June 2nd to 4th, 2027) in Leiden.

If you do not want to miss anything, follow us and sign up for our mailing list: www.universiteitleid...

1 month ago 7 2 0 0
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Interesting talk by Karlijn Meerman at #KNCVMCCB2026. She talked about her #PhD research in the @feringalab.bsky.social about making photoswitchable cyclic peptides in collaboration with Nathaniel Martin of our @led3hub.bsky.social.

#ChemSky #ChemBio #Peptides #PhotoSwitch

1 month ago 2 1 0 0
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Amazing talk by @janavolaric.bsky.social from our Molecular Physiology Department and @led3hub.bsky.social at #KNCVMCCB2026. She talked about her postdoctoral research in the Ed Tate lab into optical control of S-acyltransferase activity in mammalian cells.

#ChemSky #ChemBio #GeneticCodeExpansion

1 month ago 2 1 0 0
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How can virtual screening be combined with in-house synthesis to quickly evaluate hits?

@seanmckenna.bsky.social from our @led3hub.bsky.social talked about his exciting work on COMBINAUT that allows automated synthesis and purification.

chemrxiv.org/doi/full/10....
#ChemSky #ChemBio #DrugDiscovery

1 month ago 6 1 0 0
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Predicting the stereochemical outcome of glycosylations is a complex problem.

In his talk at #Lunteren2026, Daan Hoogers from the group of Jeroen Codee of our @led3hub.bsky.social presented his research into the systematic exploration of this question.
pubs.rsc.org/en/content/a...
#ChemSky #ChemBio

1 month ago 8 2 0 0
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Great to hear the full story of this exciting project that is done in collaboration with, among others, @mads-chem.bsky.social of our @led3hub.bsky.social. (2/2)

#ChemBio #ChemSky #Synthesis #SAR #Tuberculosis #Virulence #ABPP #PAL

1 month ago 4 1 0 0
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We urgently need new antibiotics against the most devastating Gram-negative infections.
I am excited that Thomas Clairfeuille from Roche will visit us for a @led3hub.bsky.social Lecture on March 26th to talk about Zosurabalpin, a recent success story in the field.(1/2)
www.nature.com/articles/s41...

1 month ago 5 1 1 0
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We are looking forward to the LED3 Lecture by Thomas Clairfeuille from Roche on March 26th. He will talk about "The discovery and mechanism of lipid transport inhibition by the antibiotic Zosurabalpin"

www.universiteitleiden.nl/en/science/l...

#ChemBio #ChemSky #Antibiotics #DrugDiscovery

1 month ago 1 1 0 0

It was great to be part of the discussion about the faculty priority themes of @leidenscience.bsky.social and to represent the @led3hub.bsky.social alongside @mvdstelt.bsky.social, Laura Heitman and @kimmb1.bsky.social.

1 month ago 3 1 0 0
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ABPP2027 The 15th International Activity-Based Protein Profiling Meeting will be held in Naturalis, Leiden, The Netherlands from June 2nd to 4th, 2027. This meeting will discuss the latest advancements in prot...

Save the date! 15th Activity Based Protein Profiling meeting #ABPP2027 is in Leiden, 2-4th June 2027. Join the mailing list for program updates and rego: www.universiteitleiden.nl/en/science/led3/abpp2027
#chembiol #proteomics #ABPs #Chemicalprobes @led3hub.bsky.social @leidenscience.bsky.social

1 month ago 5 2 0 1
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Our theme leader, @mvdstelt.bsky.social, introduces our LED3 hub at the meeting of all of our faculty priority themes of @leidenscience.bsky.social. Great discussions on the annual and communication plan and the outlook for the future. Exciting things ahead.
www.universiteitleiden.nl/en/science/l...

1 month ago 2 1 0 1
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Interested in Activity-based Protein Profiling?

We are excited to host the 15th Activity-based Protein Profiling meeting (@abpp2027.bsky.social #ABPP2027) on June 2nd to 4th, 2027, at Naturalis in Leiden.

Save the date and sign up for our mailing list: www.universiteitleiden.nl/en/science/l...

1 month ago 13 7 0 0

We hope you all enjoyed Christina's talk as much as we enjoy sharing our science! Seems like it was a packed house 🫡

1 month ago 3 2 0 0
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Amazing @led3hub.bsky.social Lecture by @thewoolab.bsky.social! She talked about her group's exciting work on protein C-terminal cyclic imids as natural ligands of cereblon for protein degradation. (1/3)
www.nature.com/articles/s41...

#TPD #DrugDiscovery #ChemBio #ChemSky #Degron

1 month ago 13 1 1 0
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We are very happy that Christina Woo (@thewoolab.bsky.social) visited us for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation.
#TPD #ChemBio #ChemSky

1 month ago 8 1 0 1
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@thewoolab.bsky.social at @led3hub.bsky.social seminar series on Rewriting Protein Modifications
#LED3

1 month ago 4 2 0 0

The Activity-Based Protein Profiling Conference #ABPP2027 is coming to Leiden on June 2nd to 4th, 2027.

Already mark your calendars! We hope to be able to welcome many of you in Leiden.

1 month ago 1 1 0 0

#DrugDiscovery #Automation #VirtualScreening #MedicinalChemistry #HitDiscovery #ChemSky #ChemBio

2 months ago 0 0 0 0
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New preprint from our LED3 hub on ChemRxiv!

The labs of @sebastianpomplun.bsky.social , @gjpvwesten.bsky.social and Laura Heitman with first author @seanmckenna.bsky.social present COMBINAUT: an automated parallel synthesis platform for rapid access to 22.9M-compounds.

chemrxiv.org/doi/full/10....

2 months ago 7 3 1 0