🔬 Studying #protein-DNAinteractions and wondering how freely-diffusing #single-molecule techniques can support your research? Here are a couple of the most commonly asked questions we hear from scientists in this space. Find more on our protein-DNA application page > buff.ly/uOHzEy5
Find Tim and Charlotte at today's #LondonPolymerGroup meeting (at @imperialcollegeldn.bsky.social) to learn how single-molecule data can complement your existing workflows to reveal polydispersity and #polymer conformational dynamics, and confirm nanoparticle cargo loading or leakage in real-time.
👀 How can #FCS be used to quantify interactions of #proteins with binding partners? See how Prof Elizabeth Rhoades' lab used FCS, along with other biophysical methods, as a tool to investigate cellular internalisation of disordered proteins linked to neurodegeneration > youtu.be/Z7nbpW1xBpg?...
🤔 How do #proteins reshape RNA dynamics? Static structures tell only half the story. Using smFRET on the EI-FLEX, the @chillzaa.bsky.social lab at @yorkuniversity.bsky.social mapped viral protein–dependent RNA pseudoknot formation - revealing it as a binary, protein-triggered event > buff.ly/IVQYK72
👀 Your #molecules are doing something exciting! But what, exactly? Discover - when and why - #smFRET is the method of choice to use alongside your current techniques, adding a layer of dynamic data that can quantify #biomolecularconformations and complex formation. Learn more > buff.ly/arAGYZ4
🙌 Congratulations to Chadda et al. on their new paper! #smFRET on the EI-FLEX provided a highly complementary technique alongside SEC, mass spectrometry, mass photometry & bulk FRET to elucidate the pathway that forms mature intasomes from viral #DNA & retrovirus integrase dimers.👀 > buff.ly/mkBUmjc
👀 What Exciting things are your molecules really doing? Introducing the EI-FLEX Pro and Pro HT - designed to reveal dynamics, binding, and aggregation in real time with the ultimate single-molecule resolution and no specialist setup > youtu.be/peLNtmqAVIM
#singlemolecule #lifescience #biopharma
Using #cryoEM or AI to design proteins, but wondering how they behave in solution at the single-molecule level? We’re excited to sponsor NESBA’s Designing Structure symposium. Stop by our booth to chat about uncovering dynamics beyond static structures.
🎟️ www.eventbrite.com/e/designing-...
Download our latest app note (produced in collaboration with the Coleman Lab at Lawrence Livermore National Laboratory) to discover how #FCS can be performed to assess #antibody-antigen binding affinities and generate Kd values for candidate molecules > excitinginstruments.com/resource-lib...
👋 Struggling to resolve cell membrane receptor organisation with standard imaging? #FCS offers the resolution and flexibility needed to probe #membranedynamics in detail.
In this seminar, Joelle shares how FCS reveals:
• Diffusion
• Expression
• Stoichiometry
Watch here 👉 youtu.be/YzFw-TLG1Bk
👀 In our new application note, we demonstrate how fluorescence cross-correlation spectroscopy (FCCS) can be performed on the EI-FLEX system to characterise the formation of a ternary complex > excitinginstruments.com/resource-lib...
#ternarycomplex #fccs #PROTACs #molecularglues
Who's heading to the #ClimbTour #Sheffield edition tomorrow? Our very own @timcraggs.bsky.social will be joining a great lineup of founders, investors, and ecosystem leaders, coming together for an afternoon of insights and networking. Hope to see you there 🙌 #entrepreneurs #innovation #climbuk
📢 New application notes, single-molecule discoveries, seminars, society meeting sponsorship (and pizza 🍕), and more! Read the latest Exciting Insights newsletter and share with colleagues:
26707290.hs-sites-eu1.com/-temporary-s...
Subscribe: share-eu1.hsforms.com/2tB-S9AikSdG...
Check out our Novalix conference poster below, with a focus on true #ternarycomplex formation and cooperativity, and how the EI-FLEX Pro supports dynamic #proteincharacterisation in #induced-proximity #drugdiscovery. Email info@excitinginstruments.com to discuss the poster in more detail.
🔍 Want to know whether your biomolecules form static, heterogeneous populations or are dynamically interconverting? Our latest appnote highlights how the EI-FLEX system can recover rates of molecular #conformationaldynamics, using #DNA hairpins as a well-characterised test system > buff.ly/zRH2KmM
Want to add easy access to #smFRET, #FCS and #FCCS to your core facility? Our new tools for single-molecule measurements offer:
💪 Reliable performance
⚡ Intuitive workflows
🦶 Small footprint, big impact
Learn more and get in touch > buff.ly/q8KQw0i
#corefacilities #biophysics #singlemolecule
👀 At #BPS but haven’t stopped by booth 401 yet? Meet the team to discover how you can unlock the ultimate #single-molecule resolution at your benchtop, generating high-impact insights into #biomolecular interactions and dynamics. See you there! @biophysicalsoc.bsky.social #biophysics #lifescience
At the final day of the @novalix.bsky.social conference? If you haven't had chance to meet with Audrey and Jake yet, there's still time to discuss how confocal fluorescence spectroscopy can accelerate your induced-proximity drug screening ⚡
#ternarycomplex #molecularglues #PROTACs #novalix
🚀 Big news from @timcraggs.bsky.social x #BPS2026: meet the new EI-FLEX Pro! Automated alignment + focus, real-time analysis with publication-ready plots, modular upgrade to 96/384 wells, no darkroom or optical table, compact benchtop. Meet us at booth 401 or get in touch for a demo! #singlemolecule
What better way to start your day than by exploring the key components of a confocal FRET experiment that ensure single-molecule sensitivity and accurate determination of FRET efficiencies? > buff.ly/NMausGH #singlemolecule #FRET #molecularbiophyics #biochemistry #molecules
Heading to #SLAS2026 today? Make sure you catch our East Coast BDM, Jake Isaacs, on the Topical Interest Group #ProximityAssays panel discussion "From #Degraders to PPI Modulators: The Expanding Universe of Proximity Medicines" at 1pm in room 204AB 💡
🇺🇸 Heading to #Novalix? Learn how confocal fluorescence spectroscopy accelerates induced-proximity drug screening. Meet our US team, Audrey & Jake, to discuss #biophysicalscreening, #molecularglues and #PROTACs, #single-molecule #proteindynamics, and more. Look out for their booth and poster!
Congratulations to Alison Twelvetrees, Evelyn Smith and team at the University of Sheffield on their publication in iScience! - www.cell.com/iscience/ful...
Amazing to see the in-cell labelling and smFRET measurements in cell lysate.
#smfret #celllysate #singlemolecule #proteins
☕ Grab a cup of coffee and take 5 minutes to read the latest edition of our newsletter > 26707290.hs-sites-eu1.com/-temporary-s...
Subscribe to never miss a future edition > share-eu1.hsforms.com/2tB-S9AikSdG...
#biophysics #biochemistry #singlemolecule
🧐 Curious how #single-moleculeFRET measures nanoscale distances with Å precision? Our #appnote note shows smFRET on the EI-FLEX using #DNA standards, ALEX for clean FRET/stoichiometry, and Förster radii to calculate inter-dye distances > excitinginstruments.com/resource-lib...
👀 Looking for #mechanisticinsight beyond traditional biochemistry? Our EI-FLEX system reveals in-solution dynamics, kinetics & rare events with intuitive software that delivers publication-ready plots and clear interpretation in minutes. No biophysics expertise needed 💪> buff.ly/FTlfZgO
Want to add fast, solution-based #single-molecule dynamics to your workflow? Our new, practical handbook shows how confocal #smFRET reveals conformational change, heterogeneity & nanoscale distances, with clear, step-by-step guidance from basics to advanced analysis > buff.ly/xHefIrP
📢 Structural biochemists: do you have beautiful, atomic-resolution static structures, but feel like a piece of the puzzle is missing? Add single-molecule dynamics with smFRET to reveal hidden conformational changes 👉 excitinginstruments.com/resource-lib...
#structuralbiology #proteindynamics
🇺🇸 Are you in #SanFrancisco this week for #JPM26, or local to the area, and curious to learn more about the power of high-throughput single-molecule characterisation?
Drop @timcraggs.bsky.social or @robertbell.bsky.social a DM if you'd like to meet up to learn more!
Special thanks also to the
@ei-science.bsky.social team for equipping us with #fcs capabilities in @ybri-uoy.bsky.social & @york.ac.uk thanks to support from EPSRC!
@uoyopenres.bsky.social
