Deltaviruses spread through a viral Trojan Horse McKellar et al. have discovered that some satellite viruses act as the ultimate hitchhikers. They physically become a virus inside a virus, hiding within helper virus particles by hitching a ride as a...

This week #JournalClub @labsoap.bsky.social @cellpress.bsky.social @karimaj.bsky.social #virusinavirus #virus #spreading www.cell.com/cell/fulltex...

Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder This study describes the cell-type-specific lysosomal proteome across the major brain cell types and identifies SLC45A1 as a neuron-specific lysosomal sugar exporter linked to lysosomal storage diseas...

This week #JournalClub @labsoap.bsky.social #lysosome #brain @cellpress.bsky.social @abu-remaileh.bsky.social www.cell.com/cell/fulltex...

Unraveling the Dynamics of Oxytocin in Hypothalamic Neurons Oxytocin (OT) plays an important role in regulating social behavior, and dysregulation of the oxytocinergic system leads to social impairments, such as autism spectrum disorder. Central OT release is...

Just Published !

onlinelibrary.wiley.com/doi/10.1111/...

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy - Nature Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuro...

This week #JournalClub @LabSoap @nature.com #mitochondria transfer #astrocyte #neuron #nanotube Mitochondrial transfer from glia to neurons protects against peripheral neuropathy www.nature.com/articles/s41...

Autophagolysosomal exocytosis inverts Src kinase onto the cell surface in cancer Overexpression of the proto-oncogene Src is common to a wide variety of cancers. In this work, we found that Src is noncanonically translocated and inverted onto the cell surface in cancer, both in vi...

This week #JournalClub @labsoap.bsky.social
#Src #lysosome #autophagy #exocytosis welcome to the upside-down 😱 @science.org www.science.org/doi/10.1126/...

This week #JournalClub @labsoap.bsky.social @nature.com #ageing #metastasis #stressresponse www.nature.com/articles/s41...

@labsoap.bsky.social proud to take part in #BrainAwarenessWeek @semaineducerveau.bsky.social , where we engaged with the public on the topic of #brain #tumors
It was a great opportunity to share our research and raise awareness about the challenges and advances in this field.

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

This week #JournalClub @labsoap.bsky.social @science.org #cGAS_STING @idikic.bsky.social www.science.org/doi/10.1126/...

💪 the almost final program is now available

📍btmbts26.sciencesconf.org/data/pages/PgBTMBTS_27.p...

🕐 still time to register and present a poster

💪 the almost final program is now available

📍btmbts26.sciencesconf.org/data/pages/PgBTMBTS_27.p...

🕐 still time to register and present a poster

A lysosomal requiem for glioblastoma cells Once viewed solely as degradative compartments, lysosomes shape cell fate through signaling, metabolism, and communication. In glioblastoma, their rew…

take a look to our #forum on #lysosome #glioblastoma out @cp-trendscancer.bsky.social

🧠 "A lysosomal requiem for glioblastoma cells"

lnkd.in/e3Zcb46y

🙌 Laura Merlet Margaux LE GUYON Julie Gavard

www.sciencedirect.com/science/arti...

Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity - Nature The ALPK1 agonist UDSP-Hep stimulates tumour-cell antigen presentation, macrophage–DC cross-priming and differentiation of protective memory T cells.

This week #JournalClub @labsoap.bsky.social #immunotherapy #inflammation #cGAS-STING @nature.com www.nature.com/articles/s41...

🗣️You can NOW (at last) register for the Brain Tumor Meeting By The Sea which will be held in #StMalo from March 23 to March 25 here btmbts26.sciencesconf.org

🤩The keynote speakers are @annagolebiewska.bsky.social, #David_Castel and @benjaminwerner.bsky.social

poke @labsoap.bsky.social

poke @elodie-lafont.bsky.social @tonyavril.bsky.social @xguillory.bsky.social @insermgrandouest.bsky.social @labsoap.bsky.social @rennesuniv.bsky.social @inserm.fr

fantastic venue, fantastic program, just apply and spread the word 🧠 🌊💺

The integrated stress response promotes immune evasion through lipocalin 2 - Nature The transcription factor ATF4 and its effector lipocalin 2 (LCN2) have a key role in immune evasion and tumour progression, and targeting the ATF4–LCN2 axis might provide a way to treat several t...

This week #JournalClub @labsoap.bsky.social #immunotherapy #resistance #evasion @nature.com www.nature.com/articles/s41...

Here’s the classic lab SOAP-box picture, sometimes copied but un-equalized, and full of memories.

Sad to see some familiar faces leaving, but so excited to welcome new colleagues, and sometimes old friends we are hoping to see back to @labsoap.bsky.social

Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer How tumor cells overcome anti-tumor immune responses and drive cancer recurrence is not well understood. Yu et al. demonstrate how therapy-resistant breast cancer cells synthesize and secrete arachido...

This week #JournalClub from @LabSoap @cp-immunity.bsky.social #lipid #neutrophils #TNBC #breastcancer #resistance www.cell.com/immunity/abs...

Meningeal blood vessel blockage enhances anti-glioblastoma immunity Meningeal blood vessel blockage enhances anti-tumor immunity against GBM in preclinical models by expanding dural resident border-associated macrophages, which are equipped with an elevated antigen-pr...

This week #JournalClub @labsoap.bsky.social @cellpress.bsky.social #glioblastoma #immune_responses #meningeal_vessels www.cell.com/cell/abstrac...

Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation Platelet integrin αIIbβ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of αIIbβ3 by von Willebrand factor or fibrin under flow triggered its accumulation in plasma ...

This week #JournalClub @labsoap.bsky.social @nature.com #integrin #tetraspanin #migration www.science.org/doi/10.1126/...

IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation Identifying the cell of origin that harbors an initial driver mutation is key to understanding tumor evolution and for the development of new treatments. For isocitrate dehydrogenase (IDH)–mutant glio...

This week #JournalClub @labsoap.bsky.social @science.org #glioblastoma #IDH1 www.science.org/doi/10.1126/...

Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...

This week #JournalClub @labsoap.bsky.social #lysosomes #ER #secretion @nature.com www.nature.com/articles/s41...

This week #JournalClub @labsoap.bsky.social @nature.com #celldeath #plasmamembrane #rupture #MLKL #necroptosis www.nature.com/articles/s41...

Microbial signals in primary and metastatic brain tumors - Nature Medicine A combination of high-resolution spatial imaging, spatial proteomics and transcriptional data reveals sparse and heterogeneous bacterial signals in gliomas and brain metastases.

This week #JournalClub @labsoap.bsky.social #glioblastoma #microbiota @natureportfolio.nature.com www.nature.com/articles/s41...

This week no #JournalClub @LabSOAP - it's #SOAPosium celebrating a decade in #Nantes 🎂🎁🎈🎄⛄

Membrane potential mediates the cellular response to mechanical pressure Mechanical forces influence cellular decisions to grow, die, or differentiate, through largely mysterious mechanisms. Separately, changes in resting m…

This week #JournalClub @cellpress.bsky.social #membrane #pressure #Hippo #density www.sciencedirect.com/science/arti...

From Mechanisms to Therapy: Exploring the Role of Ferroptosis in Cervical Cancer Transformation and Treatment This review mainly discusses the role of ferroptosis in cervical cancer from four aspects: underlying mechanisms, stage-specific sensitivity, ferroptosis-related targets and biomarkers, and clinical ...

Just published !

onlinelibrary.wiley.com/doi/10.1111/...

Strain‐Dependent Immune Signaling by Small Extracellular Vesicles Derived From Trypanosoma cruzi‐Infected Macrophages Chagas disease, caused by Trypanosoma cruzi, remains a major treatment challenge due to variations in host immunity and parasite strains. We found that small extracellular vesicles (EVs) from infecte...

Just published !

onlinelibrary.wiley.com/doi/10.1111/...

Just Published!

Spatiotemporal Analysis of Glucagon Secretory Granule Dynamics - Ghignoli - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/abs/10.1...

Just Published !

Virion Associated Importin Subunit Beta‐1 Augments Nuclear Import of HIV‐1 Pre‐Integration Complex - Yandrapally - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...