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Posts by Stephen McLaughlin

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Assembly and phospho-regulatory mechanisms of the budding yeast outer #kinetochore KMN complex. New study from Noah N. Turner (@noahnturner.bsky.social), David Barford and colleagues @mrclmb.ac.uk:
rupress.org/jcb/article/...

#CellDivision #StructuralBiology #kinetochores #centromeres #cryoEM

5 days ago 9 8 1 0
Three-year funded postdoctoral fellowship for scientists returning after a 12-month career break, deadline May 17, 2026.

Three-year funded postdoctoral fellowship for scientists returning after a 12-month career break, deadline May 17, 2026.

The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year.

Applications are open now!

More details: mrclmb.ac.uk/careers-and-...

Please share this post with anyone who may be interested!

1 week ago 15 17 0 2

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...

3 weeks ago 203 74 9 2
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📣 Physicists and engineers: apply your experimental skills to biology! Join the group of Katerina Naydenova @imprs-lm.bsky.social for a #PhD to develop new technologies that enable answering fundamental biological questions. Apply NOW!

1 month ago 10 11 0 1
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🔍 Want to uncover how proteolytic enzymes in the ubiquitin system work—and exploit those insights for novel therapeutic approaches? Apply to the Gersch Lab @maltegersch.bsky.social at @imprs-lm.bsky.social.
#proteolysis #ubiquitin #biochemistry #proteinchemistry

1 month ago 8 7 0 0
3D molecular model showing a complex protein structure with blue, green, pink, and gray regions bound to a twisted blue DNA strand.

3D molecular model showing a complex protein structure with blue, green, pink, and gray regions bound to a twisted blue DNA strand.

📣 Fully funded PhD position available!
Join @suyangzhang.bsky.social’s group to uncover how human cells coordinate RNA transcription and splicing. You’ll use biochemical, structural & cellular approaches, including #cryoEM.
Apply by 14th April.
More details: mrclmb.ac.uk/careers-and-...
#PhDposition

4 weeks ago 13 11 0 1
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BBC Radio 4 - In Our Time, Archaea How a discovery in the 1970s changed the theory of the origin of complex life on earth.

Archaea hit prime time: www.bbc.co.uk/programmes/m...

1 month ago 99 42 8 2

We are RECRUITING for maternity cover for our NMR facility at the UCL School of Pharmacy - expected from April until February. Come and join us! Details below, feel free to reach out to me informally for more information. Closing date *9 March*.

1 month ago 3 4 0 0

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab.
@mrclmb.bsky.social

Please get in touch if you have any questions.
www.nature.com/naturecareer...

1 month ago 51 54 1 0
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Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis
www.biorxiv.org/content/10.6...

2 months ago 135 61 3 4
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Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳

mrc.tal.net/vx/mobile-0/...

2 months ago 83 106 1 3
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How did life arise from simple chemical building blocks?

New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.

Read more: mrclmb.ac.uk/news-events/...

2 months ago 53 31 0 2
Suyang Zhang smiles in front of a blurred laboratory background

Suyang Zhang smiles in front of a blurred laboratory background

Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry.
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs

2 months ago 5 11 0 0
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Molecular Techniques Training Seminars 2025 - YouTube The recordings are from the LMB's recent series of training seminars 'Biophysical Techniques Course: Solving Probes with Molecular Techniques.' Featuring exp...

Are you interested in finding out how biological questions can be investigated with a range of molecular techniques? Find out how the MRC-LMB facilities tackle problems here:

www.youtube.com/playlist?lis...

2 months ago 1 0 0 0
Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle - Nature Communications To maintain genome stability, the specialised reverse transcriptase telomerase processively adds telomeric DNA repeats to chromosome ends. Here the authors reported structures of human telomerase at t...

Excited to share our latest work on dissecting the mechanism of processive telomeric DNA synthesis by telomerase. Led by amazing PhD student Sebastian Balch in collaboration with lab members,@automnenine.bsky.social @rachael-kretsch.bsky.social,@rdaslab.bsky.social.
www.nature.com/articles/s41...

2 months ago 51 15 2 2
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Postdoctoral Researcher - Structural Studies - Dr Suyang Zhang - LMB 2761 - Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12852642 Postdoctoral Researcher Salary £42,694 per annum  MRC Laboratory of Molecular Biology, Cambridge, UK We are recruiting a Postdoctoral Researcher to...

🚨Postdoc opportunity🚨Our lab at MRC-LMB Cambridge is recruting a postdoc to study transcription-coupled splicing using cryoEM and endogenous isolation! 🔬 🧬

Please feel free to get in touch directly #postdoc #cryoEM #biochemistry #splicing

Apply here by 11 Feb
www.nature.com/naturecareer...

2 months ago 15 17 0 2
HMS - Postdoctoral Fellow in BCMP, Brown Lab We invite applicants for a postdoctoral fellow position in the Brown lab at Harvard Medical School in Boston, Massachusetts. The Brown lab uses structural, biophysical, and biochemical approaches to d...

Our lab is seeking a Postdoctoral Fellow. The position is intentionally broad, as we are looking for outstanding researchers from diverse scientific backgrounds to advance our understanding of cilia and ciliopathies: academicpositions.harvard.edu/postings/15526

5 months ago 22 19 0 1

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

5 months ago 52 40 0 0
Join the LMB's PhD programme!
Applications now open for October 2026
Deadline 2nd December 2025

Join the LMB's PhD programme! Applications now open for October 2026 Deadline 2nd December 2025

Want to join the LMB as a PhD student in October 2026?
You’ve got two weeks left to apply!
Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int...
Applications close on 2nd December 2025.

5 months ago 8 12 0 0
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Thanks to the speakers and all who attended our Next Generation Biophysics Symposium. We now looking forward to the 10th Symposium on 16th September 2026. Here is a link to catch up on what happened in this year's

5 months ago 2 0 0 0
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Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...

Assembly, architecture and functional roles of microbial surface layers

Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.

S-layers are everywhere!

www.nature.com/articles/s41...

5 months ago 87 32 3 6
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Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs

5 months ago 28 23 1 0
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Our lab @mrclmb.bsky.social in Cambridge is seeking a passionate PhD student to explore transcription-coupled splicing! Join our team for an exciting project to understand human gene regulation 🧬 Feel free to get in touch directly #PhD #cryoEM #biochemistry

www2.mrc-lmb.cam.ac.uk/students/int...

5 months ago 10 11 0 0
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Biological Laboratory | LEGO® Ideas This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗
beta.ideas.lego.com/product-idea...

6 months ago 222 131 8 12
Join the LMB's PhD programme!
Applications now open for October 2026
Deadline 2nd December 2025

Join the LMB's PhD programme! Applications now open for October 2026 Deadline 2nd December 2025

Considering a PhD in molecular biology?
Make sure to check out the projects on offer at the LMB!
www2.mrc-lmb.cam.ac.uk/students/int...
General applications by 2nd DEC.
US Gates Scholarship applications by 15th OCT.
#PhD

6 months ago 8 7 0 1

Is that a pointer, looks more like a jedi sword!

7 months ago 0 0 1 0
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Excited that we are only two weeks away for our Next Generation Biophysics Symposium 2025. We have a fantastic line-up of speakers. Registration is closing soon. Come in person or view on-line
#Biophysics #SingleMolecule #CryoEM #nmr #proteindynamics

8 months ago 4 1 3 0
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Desert Island Discs - Professor Dame Carol Robinson, scientist - BBC Sounds Dame Carol Robinson, scientist, shares the soundtrack of her life with Lauren Laverne.

Carol Robinson on Desert Island Discs - have a listen friends: www.bbc.co.uk/sounds/play/...
An inspirational scientist & friend. An example of combining scientific excellence, courage, hard work and really importantly; kindness. (Yes I’m biased, but it’s true nevertheless)
@kavlioxford.bsky.social

8 months ago 12 7 1 0
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Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps Lövestam and Scheres present a cryo-EM structure of vault particles, found during tau filament extraction from progressive supranuclear palsy (PSP) brain tissue. They reveal a symmetry shift at the va...

Sofia Lövestam's vault structure is now online in Structure @cellpress.bsky.social. 🥳

How beautifully explorative is #cryoEM! We never planned to do this. The vaults just came down with #amyloids from human brain tissue, and Sofia decided to have a closer look.

www.cell.com/structure/fu...

8 months ago 125 29 3 0
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Research Group Leader in Chemical/Synthetic Biology at MRC Laboratory of Molecular Biology Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

9 months ago 27 33 1 4