Unlocking how dogs' fungal ear infections evade treatment Mutations in a key protein make a yeast found in dogs with common outer ear infections more resistant to the topical antifungals used to treat it, veterinarians and pathobiologists at the University…

How #dogs' #fungal #ear #infections evade treatment ...

| #fungi | #yeast | #MicroSky | #antifungals | #pathobiology | #canine | Via @sciencex.bsky.social

22-23 PHARMA - Fast and the curious This month: the NHS as a dystopian game of Tetris, the GLP-1 explosion and its impact on future meds, plus deep dives into AI in pharma, reproductive health, and Trump’s healthcare influence. Also, co...

#mRNAvaccines #GLP1 #obesity #CARTcelltherapies #oncology #PCSK9inhibitors #HepatitisC #Immunotherapy #checkpointinhibitors #RSVvaccines #Genetherapies #rarediseases #antivirals #Biosimilars #expandedaccess #biologics #HIV #Migraine #CGRPinhibitors #antifungals #precisionmedicine
zurl.co/3UDz7

News : Basilea

Basilea Pharmaceutica and Prokaryotics, Inc. announced a collaboration to develop a first-in-class, broad-spectrum antifungal for severe invasive infections, including those caused by Candida, Aspergillus, and rare molds.

Read here ➡️ www.basilea.com/news#news_1576

#Antifungals #AntiInfectives

Please support the ESICM & ESCMID–endorsed survey on antifungal strategies after abdominal surgery.
Your input (5–7 min) will help improve guidelines and stewardship.
Thank you!
➡️ www.clinicalsurveys.net/uc/SURG_MYC/
#InfectiousDiseases #ICU #Surgery #Antifungals

EPA urged to ban spraying of antibiotics on US food crops amid resistance fears Use of 8m pounds of antibiotics and antifungals a year leads to superbugs and damages human health, lawsuit claims

#EPA urged to ban spraying of #antibiotics on U.S. #food #crops amid resistance fears ...

| #antifungals | #superbugs | #health | #agriculture | Via @theguardian.com

EPA urged to ban spraying of antibiotics on US food crops amid resistance fears Use of 8m pounds of antibiotics and antifungals a year leads to superbugs and damages human health, lawsuit claims

'EPA urged to ban spraying of antibiotics on US food crops amid resistance fears'
www.theguardian.com/environment/...

'Use of 8m pounds of antibiotics and antifungals a year leads to superbugs and damages human health, lawsuit claims'

#antibiotics #antifungals #pesticides #PublicHealth

Closeup of two clusters of purple grapes hanging from a branch. The rest of the vineyard blurs into the background.

Disease risk is growing as more than 475 medically important drugs are sprayed on fruits and vegetables.

The overuse of #antibiotics and #antifungals as #pesticides on crops threatens public health — it can lead to superbugs and fungal infections that are less treatable.

Read on ➡️ bit.ly/3K7qwHY

Use the right treatment for the right condition!

#Antibiotics ≠ #Antivirals ≠ #Antifungals
Each will target ≠ types of #infections, so it’s important not to confuse them

This will prevent your symptoms from getting worse
📖 Learn + https://shorturl.at/I6onD

#EAAD #WAAW #prevention

'Rotten egg' gas could be the answer to treating nail infections, say scientists Hydrogen sulfide, the volcanic gas that smells of rotten eggs, could be used in a new treatment for tricky nail infections that acts faster and with fewer side effects, according to scientists at the…

#Rotten #egg #gas could be the answer to treating #nail #infections ...

| #H2S | #Hydrogensulfide | #fungi | #diabetics | #antifungals | By @uniofbath.bsky.social via @sciencex.bsky.social

Aspergillus fumigatus effector crpA orchestrates host prostaglandin signaling to promote fungal virulence - PubMed Conidia are the primary infection structures in <i>Aspergillus fumigatus</i>, the etiologic agent of aspergillosis. Here, we characterized CrpA (a cysteine-rich protein), a conidial surface-associated protein important for fungal e …

New study reveals the A. fumigatus effector CrpA hijacks host prostaglandin signaling to boost virulence — a promising antifungal target.
🔗 pubmed.ncbi.nlm.nih.gov/40938145/

#Aspergillus #FungalPathogenesis #Immunology #CrpA #mBio #HostPathogenInteraction #Antifungals

Tomorrow at #TIMM2025:
📍 2:15 PM – I’ll be speaking on clinical trial design for new antifungals (Room 0B)
📍 4:15 PM – PD Dr. Philipp Köhler will cover starting antifungal therapy (Room 0D)
Looking forward to the discussions!
#InfectiousDiseases #Antifungals #ClinicalTrials #MedicalMycology

📢 Presented at #MYK2025 by @salmantongarcia.bsky.social : Current trends on antifungal prophylaxis in solid organ transplantation – an ESCMID/SEIMC study exploring real-world practices to guide IFI management in transplant centers. #Transplant #Antifungals

New class of antifungals show potent effects against priority pathogens Coniotins, found in another fungus, is effective against drug-resistant pathogenic fungi

New class of #antifungals show potent effects against priority #pathogens ...

| #fungi | #prefractionation | #lipopeptaibiotics | #Coniochaeta | By @robinson-julia.bsky.social via @chemistryworld.com

Towards shorter therapy for candidaemia: defining uncomplicated candidaemia in adults Although the characteristics of complicated candidaemia are well known, uncomplicated disease remains undefined. Recommended treatment duration for candidaemia is 14 days after bloodstream infection i...

Defining uncomplicated candidaemia in adults: controlled source, clinical response & bloodstream clearance within 5 days. Could this allow shorter antifungal therapy? 🧫💉 Read more: www.thelancet.com/journals/lan...
#Candidaemia #Antifungals #InfectiousDiseases #ClinicalResearch

New class of antifungals show potent effects against priority pathogens Coniotins, found in another fungus, is effective against drug-resistant pathogenic fungi

New class of antifungals show potent effects against priority pathogens #Science #HealthandMedicine #InfectiousDiseases #Antifungals #PublicHealth

Thirty years of research shows increased resistance in fungi Fungi are increasingly resistant to antifungals, and the variation in resistance has significantly increased. This is evident from the analysis of more than 12,000 lung samples collected over 30…

Thirty years of research shows increased resistance in #fungi ...

| #fungus | #fungal | #antifungals | #infections | #Aspergillus | Via @sciencex.bsky.social

Tým vedený prof. Janem Konvalinkou připravil látku, která v laboratorních podmínkách ničí kvasinkovou houbu #Cryptococcus neoformans, smrtelně nebezpečnou pro lidi s oslabeným imunitním systémem. 🧵

#chemistry #Cryptococcus #chemie #uochb #iocb #iocbprague #antifungals #popularizace

Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study Only a small number of antifungal therapies for invasive fungal disease (IFD) are currently available, and many pathogens are resistant to one or more…

New hope for hard-to-treat fungal infections: Phase 2b results show #Olorofim is effective and well-tolerated in patients with few or no treatment options.
Read in The Lancet Infectious Diseases 👉 www.sciencedirect.com/science/arti...
#IFD #Antifungals #ClinicalTrials

🧪 Curious about how new antifungal treatments are developed? Dr. Jon Salmanton-García explains the full journey - from preclinical research to phase III trials, highlighting key challenges, innovations, and the fight against resistance. youtu.be/ekLy55XheKE #Antifungals #ClinicalTrials

Proud to co-chair with Jon Salmanton-García the session on clinical trials for new antifungals at ISHAM 2025 🧪🦠 We tackled challenges in trial design, recruitment, and resistance - paving the way for future treatments. Exciting times ahead! #ISHAM2025 #Antifungals #ClinicalTrials

📅 #ISHAM 2025 – Wed, May 21
🔬 Our Contributions, Your Insights
Join us to advance fungal research:
Jon Salmanton-García – Unlocking the basics: Antifungal trials
Oliver Cornely – Clinical trials for new antifungals
Danila Seidel – Climate change & the rising threat
#Antifungals #FungalThreats

#research #medchem #antifungals

On-Resin Assembly of Macrocyclic Inhibitors of Cryptococcus neoformans May1: A Pathway to Potent Antifungal Agents (Kryštůfek et al.) – @pubs.acs.org J. Med. Chem.: doi.org/10.1021/acs....

@iocbprague.bsky.social @czechacademy.bsky.social @imgprague.bsky.social

Fosmanogepix for the Treatment of Invasive Mold Diseases Caused by Aspergillus Species and Rare Molds: A Phase 2, Open-Label Study (AEGIS) Fosmanogepix 1000mg IV (loading dose) and 600mg IV or 800mg oral (maintenance dose) was associated with an all-cause mortality of 25% at Day 42 with accept

🦠 New study in Clinical Infectious Diseases: Fosmanogepix shows potential for treating invasive mold infections by Aspergillus & rare molds in high-risk patients with limited options.
📄 Read more: doi.org/10.1093/cid/...
#InfectiousDiseases #Antifungals #FMGX

Fusariosis can be as scary as it sounds. Fungal infections might not be as common as bacterial, but when they do happen their #resistance patterns can look like this! 😱 Thanks to @olivercornely.bsky.social for bringing us the new #antifungals coming to the rescue!

#ESCMIDGlobal

Honored to present today at ESCMID Global in Vienna: Ibrexafungerp salvage results from 233 patients in the FURI study — showing high success rates! 🔬💪 A promising new tool in the antifungal pipeline. #ESCMID2025 #FURIstudy #Ibrexafungerp #Antifungals #InfectiousDiseases

🔬 Don’t miss the Pipeline Symposium PM1 tomorrow!
🕗 Monday, 14 April | 08:30–10:30 | Hall 12
💡 Progress & challenges in drug discovery
🔍 09:30 – Antifungal drugs in clinical development
#ESCMIDGlobal2025 #DrugDevelopment #Antifungals

🗓️ Join us Sunday, 13 April 2025 | 17:30–18:30 | Hall 12
🔍 What’s new in antifungal guidelines and management
Don’t miss the global candidiasis guideline update by ECMM, ISHAM & ASM and insights from the FURI study on ibrexafungerp!
#ESCMIDGlobal2025 #Antifungals #InfectiousDiseases

Achieving and maintaining therapeutic drug exposures with #Antifungals can be challenging in special patient populations, such as those with #OrganDysfunction (liver or kidney). Read more in the latest Journal of #Infection 👉 www.journalofinfecti...

Colony (top) and cellular (bottom) morphologies of the diploid and haploid strains (left and right in each pair, respectively). Left pair show strain E56, right pair show strain C23. Scale bars: 1 mm for colonies; 5 μm for cells.

The pathogen #Candida tropicalis is increasingly resistant to azole #antifungals. Although C. tropicalis was thought to be diploid, this study shows that a widely used agricultural #fungicide generates haploid cells that are cross-resistant to antifungal drugs #AMR @plosbiology.org 🧪 plos.io/3RAckqM

Colony (top) and cellular (bottom) morphologies of the diploid and haploid strains (left and right in each pair, respectively). Left pair show strain E56, right pair show strain C23. Scale bars: 1 mm for colonies; 5 μm for cells.

The pathogen #Candida tropicalis is increasingly resistant to azole #antifungals. Although C. tropicalis was thought to be diploid, this study shows that a widely used agricultural #fungicide generates haploid cells that are cross-resistant to antifungal drugs #AMR @plosbiology.org 🧪 plos.io/3RAckqM