#Bluetorial for a quick refresh
#ESHREjc

👇🏼👇🏼👇🏼👇🏼👇🏼

Revisit the #bluetorial for the discussed paper 👇🏻 #ESHREjc

The emerging role of the oocyte cortical domain in maturation, fertilization, and development - PubMed The cell cortex, a cytoskeletal network with regulatory signalling pathways, is localized beneath the cell membrane: it is especially prominent in mammalian oocytes. As in other cells, the cortex ensures appropriate shape and robustness of oocytes. It is also involved in other key and more specific …

🧬 The Oocyte Cortex: Fertility’s Hidden Control Layer

To find out join #ESHREjc on Friday 29/1 starting 17:00 CET.
@paolavigano.bsky.social @rvassena.bsky.social @enricabianchi.bsky.social&authors Giovanni Cotichio and Danilo Cimadomo

Paper ➡️ pubmed.ncbi.nlm.nih.gov/41206604/

🧵 #bluetorial 👇🏻

Step 3: check for compensation😮‍💨(4/6)

Met acidosis: resp compensation- hyperventilation🫁
Met alkalosis: resp compensation- hypoventilation

Resp: renal compensation to adjust the HCO3-
Acute-little to no compensation
Chronic- HCO3- is adjusted significantly

#medschool #medicaleducation #bluetorial

Step 1: what is the pH?🤯(2/6)

The most important thing to start with is finding out whether the pH is acidotic, alkalotic, or normal.
pH<7.35 is acidotic
pH>7.45 is alkalotic
7.35<pH<7.45 is normal, BUT that doesn’t mean everything is actually normal.

#medschool #meded #acidbase #bluetorial

Understanding Acid–Base Made Simple: A Crash Guide for Medical Students🧪

Acid-base disorders may look intimidating, but every case follows the same logic.
Here’s a simple, practical approach that will save you in exams and on the wards!(1/6)

#medschool #medicaleducation #abg #acidbase #bluetorial

Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision

#Bluetorial below👇🏼

#KRAS #Plasticity #ColorectalCancer

➡️ This important video was missing from yesterday’s #Bluetorial.

CRC organoids under treatment with KRAS inhibitor RMC-9945, rapidly acquire a LGR5+ cancer stem cell-like phenotype, allowing them to bypass KRAS inhibition, and eventually resume growth.

Centonze et al., in #CancerDiscovery

#AACR

A new step towards targeting #tumornetworks in #glioblastoma !

Very happy to have made a small contribution to this exciting work led by @danielazorin.bsky.social and @dirkchoffmann.bsky.social 💐

#cancerneuroscience #GBM #braintumors 🧠

For a #Bluetorial see 👇

Genetic mechanisms of resistance to targeted KRAS inhibition KRAS mutations are among the most prevalent oncogenic drivers in non-small cell lung cancer (NSCLC), yet the mechanisms of therapeutic resistance to KRAS inhibitors in these cancers remains poorly und...

No time for a #bluetorial today, but happy to share a new preprint from the lab. In this paper we used gene saturation and cancer-mutation-focused base editing screens to unveil genetic drivers of resistance to multiple KRAS inhibitors. www.biorxiv.org/content/10.1...

Serendipity science via #bluetorial.
Reason x/n this is a useful website.

Thank you @homeobox.bsky.social and colleagues.

a man in a suit and tie has his mouth open Alt: a man in a suit and tie has his mouth open

How much genetic function is required to avoid the worst phenotypes? For Tulp3, the answers may surprise you! New pre-print from my lab, led by postdoc Corinne McCoy, using an 8-part genotypic series in mice. #Bluetorial
www.biorxiv.org/content/10.1... 1/

Check out Andi's #Bluetorial for a summary of our findings 🙌

Check out this fabulous #bluetorial by @edelblumlab.bsky.social. Beautiful paper, finally ready it and this thread was cherry on top. 🎊🎊🎊

two men are riding a bicycle with a basket on it . ALT: two men are riding a bicycle with a basket on it .

#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🍬🍭🔬

For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime

Preprint and #bluetorial below!!

We were very fortunate to have our R35 MIRA awarded by NIGMS - start date of April 1, 2024. There is a long and personal story behind applying for this grant that could be a #Bluetorial for another time.
6/n

1/10 Small pre-Christmas #bluetorial on the workshop held by the T-cell Receptor (TR) and Immunoglobulin (IG) Nomenclature Sub-Committee of @iuis-online.bsky.social on policies and procedures for TR/IG gene annotation and nomenclature #immunerepertoire #immunogenetics

Sex-dimorphic gene regulation in murine macrophages across niches Macrophages are a key cell type of the innate immune system and are involved at all steps of inflammation: (i) they present antigens to initiate inflammation, (ii) they clear up foreign bodies through...

End of the year #bluetorial for a small meta-analysis study 💻 just preprinted led by the talented #CassieMcGill to understand recurrent sex-dimorphic♀️♂️ features of murine #macrophages across niches. #ImmunoSky #Genomics 🖥️🧪🧬 A 🧵 , 1/7 www.biorxiv.org/content/10.1...

Thanks, here you can find a #Bluetorial of our article on “Less, but more” evolution
👇🏻
bsky.app/profile/evod...

First #bluetorial. 🎉🎉 We’re very happy to share our latest biorxiv #preprint, just in time before the holiday season. We explored how transposable elements (TEs) diversify eukaryotic proteomes and found a cool case in nematode F-box genes. #TEsky #evosky #Celegans

Short 🧵 with highlights.

"LESS, but MORE" refers to the evolutionary framework characterized by massive gene losses accompanied by bursts of duplications that we describe in a MS just published in MBE about FGF evolution in appendicularian tunicates👉 bit.ly/3VGWSfd
@official-smbe.bsky.social
Here, our first #BLUETORIAL 🦋😁👇

Atomistic Mechanisms of Calcium Permeation Modulated by Q/R Editing and Selectivity Filter Mutations in GluA2 AMPA Receptors GluA2 is a key subunit of AMPA receptor ion channels that is abundantly expressed in the vertebrate brain. Posttranscriptional Q/R editing of GluA2 renders AMPARs nearly impermeable to calcium ions, w...

! 🚨Preprint Alert🚨
!
Flo and Johann’s magnum opus on calcium permeation in AMPA Receptors is up. It’s another chapter in our collaboration with Han Sun (FMP-Berlin), with ephys from our former student @ecekuru.bsky.social

www.biorxiv.org/content/10.1...

For the details, here's a #bluetorial

1/n

🚰 Water & food problems are 2 of the most pressing issues facing humanity, yet are often ignored in high-income countries. In this #bluetorial, I break down our
@naturewaterjnl.bsky.social paper examining the water-food nexus among US children 🧵1/13
nature.com/articles/s44...

I'm going to start using #bluetorial

a man in a doctor 's coat is sitting at a desk and says blood pressure ALT: a man in a doctor 's coat is sitting at a desk and says blood pressure

Hey there, #neuro enthusiasts! Ever pondered the perfect blood pressure after endovascular thrombectomy (EVT)? ⚖️

Let's dive into the latest trials (with links!) to crack this code! Buckle up, it's brain-savin’ time! 🚀 #Bluetorial #NeuroSky #MedSky #MedEd

Wonderful work! Long live the #bluetorial. 🧪🦋

Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)

Cool data & #bluetorial!

Prevalence of Iron Deficiency and Iron-Deficiency Anemia in US Females Aged 12-21 Years, 2003-2020 This study examines prevalence of iron deficiency among females aged 12 to 21 years to inform future screening strategies for iron deficiency and iron-deficiency anemia.

Our study found that nearly 40% (!) of 12-21 yo females are iron deficient.

tinyurl.com/FeJAMA

But did you know that in addition to many physical symptoms, iron deficiency is associated with multiple mental health issues?

A #medsky #bluetorial 🧵1/