Natalie Suhy's beautiful image, "Patient Stem Cell-Derived #BloodBrainBarrier In A Dish", is so much deeper. In the @joelwblanchard.bsky.social Lab, the 3-D model allows Natalie to study genetic drivers of #Alzheimers pathology in human tissue. VOTE NOW for #ArtoftheBrain Image # 11 👉 Most 💝s wins!
INCREDIBLE to see the great #CallforImages #SciArt coming from #FriedmanBrainInstitute! The Ferland Lab's Alyshia Davis' "Luminous Barrier" is stunning! #Astrocytes (💙) surround the blood vessels (❤️) of the brain to form the #BloodBrainBarrier. VOTE NOW for #ArtoftheBrain Image # 2 👉 Most ❤️'s wins!
🗓 When: June 28 – July 1, 2026
📍 Where: Salt Lake City, Utah
👉Register:
metastasis-research.org/2024/06/26/m...
#MRS2026 #MasanoriTachikawa #BloodBrainBarrier #DrugDelivery #Pharmacokinetics #Metastasis #TohokuUniversity #NeuroOncology
A #nanotechnology -based approach packages two existing #CancerDrugs into tiny particles engineered to cross the #brain's protective #BloodBrainBarrier and target #glioblastoma #tumor cells.
#BrainCancer #GlioblastomaTreatment
Lunai Bioworks acquires blood-brain barrier delivery platform for central nervous system Alzheimer’s therapies
Lunai Bioworks (NASDAQ: LNAI) has announced a $20M transaction to acquire blood-brain barrier (BBB) delivery technology and CNS Alzheimer’s drug assets from the Clemann Group. BBB delivery is a major bottleneck in CNS drug development. #Alzheimers #CNS #BloodBrainBarrier
A NEW STUDY by Chris Greene, Declan Brennan, Colin Doherty, Matthew Campbell, et al. has identified a leaky #BloodBrainBarrier (BBB) as the primary mechanism linking repetitive head injuries to long-term cognitive decline in retired athletes. Learn More @science.org 👉 www.science.org/doi/10.1126/...
Faecalibacterium, Coprococcus, and Roseburia, synthesize Short Chain Fatty Acids
#SCFA #gut #brain #health #mentalhealth #bloodbrainbarrier #BBB #vagus #nerve #microbiome #fiber #fermentation #depression #psychosis #dementia #paranoia #nutrition #PSA
www.psychologytoday.com/us/basics/sh...
As a medical school professor, I've always told students exercise is good for the brain. Now we know a key reason why.
UCSF resear...
#BrainHealth #Exercise #BloodBrainBarrier #MetabolicHealth #Longevity
www.ucsf.edu/news/2026/02/431526/scie...
Polyphenols→prodrugs: nanomedicine cracks the BBB, boosting brain exposure for neurotherapeutics 🧠🔬💊🚀🌿 @mdpiopenaccess.bsky.social #Neuroscience #OpenScience #Research #BloodBrainBarrier #Nanomedicine
Read & cite 👉 www.mdpi.com/1422-0067/27...
🧠 #PhDOpportunity
Can oral microbes influence brain health?
Our centre at @qmul.bsky.social is welcoming PhD applications to explore how the oral #microbiome interacts with the #bloodbrainbarrier and neurovascular biology.
Join us! 🔬
🔗 Apply via the link in the ad
Delighted to collaborate on this exciting #PhDOpportunity exploring links between the oral #microbiome and #brain health. This project will investigate how periodontal microbial metabolites influence the #bloodbrainbarrier and neurovascular biology. @drsimonmcarthur.bsky.social
🧠🧪
Exercise Wards Off Dementia. Exercise protects your brain from Alzheimer’s dementia by strengthening your brain’s natural defense mechanisms. #exercise #dementia #alzheimers #bloodbrainbarrier
www.instagram.com/p/DVMhbjwkUaq
Study finds that an #exercise-induced #liver protein strengthens the #BloodBrainBarrier, improving #memory and slowing #AgeRelatedDecline.
#Aging #Exercise #PhysicalActivity #Exerkine #BrainHealth
New findings suggesting that PROX1 compromises BBB integrity by negatively regulating BBB-associated Wnt signaling. #BBB #BloodBrainBarrier #cerebrovascular
hPSC-derived #BloodBrainBarrier (Neural Crest-derived Pericyte + Endothelial cell) models Flavivirus Neuroinvasion
Powassan virus or Japanese encephalitis virus, not West Nile virus, ⏬BBB in vitro
WNV infection
⏬OXPHOS transcripts in Pericyte, not in EC
#iScience 2026
www.cell.com/iscience/ful...
#Plasma platelet-derived growth factor receptor-β decrease correlates with #bloodbrainbarrier damage in #AlzheimersDisease
Jieyin Li, Anqi Li...Xuhui Chen, Dai Shi, Tengfei Guo
link.springer.com/article/10.1...
#LRP1‑targeted #polymersomes reprogram #BloodBrainBarrier trafficking, enabling rapid #Amyloidβ clearance and sustained cognitive recovery in #AlzheimersDisease models. @beppebattaglia.bsky.social @ucl.ac.uk @icta-uab.bsky.social
#CoverPage in #STTT: doi.org/10.1038/s413...
Research : doi.org/10.1038/s415...
@springernature.com
#bloodbrainbarrier #brainmetastases #braintumours #cancerdrugdelivery #her3receptor #nanomedicine
Multivalent nanomedicine targeting LRP1 at the blood–brain barrier accelerates amyloid-β clearance and restores cognitive function in Alzheimer’s models.
#AlzheimersDisease #AmyloidBeta #BloodBrainBarrier #Nanomedicine #Neurodegeneration
www.nature.com/articles/s41...
CNS Pharmaceuticals re-engineers old chemotherapies to cross the blood-brain barrier, targeting aggressive glioblastoma. Dr. Sandra Silberman explains their "back to the future" strategy and two promising drugs. #BrainCancer #Glioblastoma #Biotech #Oncology #BloodBrainBarrier #CNSPharmaceuticals
CNS Pharmaceuticals re-engineers old chemotherapies to cross the blood-brain barrier, targeting aggressive glioblastoma. Dr. Sandra Silberman explains their "back to the future" strategy and two promising drugs. #BrainCancer #Glioblastoma #Biotech #Oncology #BloodBrainBarrier #CNSPharmaceuticals
Targeted nutrient transport is gaining traction as DHA delivery research moves from mechanism to real-world market application.
longevity.technology/news/unlocki...
#UnlockingTheBrain #BloodBrainBarrier #NeuroNutrition #BrainHealth #BioAccess #longevity #CognitiveSupport #DHA #neuroscience
Focused Ultrasound Blasts Chemotherapy Pathways Into The Brain. Temporarily opens blood-brain barrier. #ultrasound #focused #bloodbrainbarrier #braincancer #chemotherapy
Engineered Fab glycosylation of a blood-brain barrier transporter single-chain variable fragment preserved functionality but did not impact anti-drug antibody formation
Godec, A. et al.
Paper
Details
#glycoengineering #bloodbrainbarrier #antibodyformation
A multicenter trial found that using #transcranial #FocusedUltrasound to temporarily open the #BloodBrainBarrier during standard-of-care #chemotherapy for #BrainCancer resulted in nearly a 40 percent increase in #OverallSurvival.
#Glioblastoma #GlioblastomaTreatment
Left: Maximum projection images of elavC155QF>QUAS-prosRi tumor brains stained with Repo and Dpn. The animals were moved from standard food to chemically defined diet (CDD) (top left), CDD minus Leu (top right), CDD minus Ile (bottom left), and CDD minus Met (bottom right) at 72hALH and dissected at 120hALH. Right: Schematic depicting the working model. Nutrient Restriction (NR) inhibits BBB glia expansion, which consequently limits brain tumor growth. The authors show that NR inhibits the expression of fat body and glia-derived Ilp6, causing downregulation of the InR/PI3K pathway in BBB glia. This results in a reduction in Path expression and the downstream mTOR-S6K pathway, causing a slowdown of BBB glial cell cycle progression. Path downregulation and defects in BBB expansion consequently led to a decrease in brain AAs, such as Leu, which hinders brain tumor protein synthesis to slow down tumor growth. Data information: ALH, after larvae hatching.
How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @joannaqd.bsky.social @chengflylab.bsky.social &co show that this is regulated by the SCL36 AA transporter Pathetic at #BloodBrainBarrier glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY
Left: Maximum projection images of elavC155QF>QUAS-prosRi tumor brains stained with Repo and Dpn. The animals were moved from standard food to chemically defined diet (CDD) (top left), CDD minus Leu (top right), CDD minus Ile (bottom left), and CDD minus Met (bottom right) at 72hALH and dissected at 120hALH. Right: Schematic depicting the working model. Nutrient Restriction (NR) inhibits BBB glia expansion, which consequently limits brain tumor growth. The authors show that NR inhibits the expression of fat body and glia-derived Ilp6, causing downregulation of the InR/PI3K pathway in BBB glia. This results in a reduction in Path expression and the downstream mTOR-S6K pathway, causing a slowdown of BBB glial cell cycle progression. Path downregulation and defects in BBB expansion consequently led to a decrease in brain AAs, such as Leu, which hinders brain tumor protein synthesis to slow down tumor growth. Data information: ALH, after larvae hatching.
How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @joannaqd.bsky.social @chengflylab.bsky.social &co show that this is regulated by the SCL36 AA transporter Pathetic at #BloodBrainBarrier glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY
Left: Maximum projection images of elavC155QF>QUAS-prosRi tumor brains stained with Repo and Dpn. The animals were moved from standard food to chemically defined diet (CDD) (top left), CDD minus Leu (top right), CDD minus Ile (bottom left), and CDD minus Met (bottom right) at 72hALH and dissected at 120hALH. Right: Schematic depicting the working model. Nutrient Restriction (NR) inhibits BBB glia expansion, which consequently limits brain tumor growth. The authors show that NR inhibits the expression of fat body and glia-derived Ilp6, causing downregulation of the InR/PI3K pathway in BBB glia. This results in a reduction in Path expression and the downstream mTOR-S6K pathway, causing a slowdown of BBB glial cell cycle progression. Path downregulation and defects in BBB expansion consequently led to a decrease in brain AAs, such as Leu, which hinders brain tumor protein synthesis to slow down tumor growth. Data information: ALH, after larvae hatching.
How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @chengflylab.bsky.social &co show that this is regulated by the SCL36 amino acid transporter Pathetic at the #BloodBrainBarrier perineural glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY
Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarrier
