#BrCa

👨‍⚕️🎥 We are back with another Ask A Cancer Researcher video! Watch Dr. Rob Grant explain how our DNA can be used to help choose the best treatment for a particular cancer. 🔎🧬 https://bit.ly/48gj4D9

#cancerresearch #pancreaticcancer #OICR #precisionmedicine #personalizedmedicine #BRCA

Hormone Therapy and Breast Cancer Risk in Women With BRCA Variant This cohort study assesses the association between hormone replacement therapy exposure and invasive breast cancer diagnosis among women in Israel carrying BRCA1 and BRCA2 pathogenic variants.

En mujeres c/variantes patogénicas del BRCA q reciben reemplazo hormonal luego de ooforectomía bilateral reductora de riesgo, ter reemplazo solo c/estrógenos se asocia c/menor riesgo de CA mama en las q tienen la variante BRCA1 #HRT #BreastCancer #brca jamanetwork.com/journals/jam...

Lesley Ann Warren plays "Candie" in Love, Danielle

#BRCA #HereditaryCancer #Previvor #Movie

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FYI: 23andMe's #BRCA test not clinical grade & only covers 44 variants out of thousands, so a negative result does not mean you are in the clear. Certified genetic counselor=most qualified to assess cancer risk, order appropriate testing panels, & interpret results. findageneticcounselor.nsgc.org

BRCA gene mutations now implicated in thyroid, bladder, skin, and head and neck cancer An international group have discovered associations between pathogenic variants of the BRCA 1 and 2 genes and four types of cancer. Published in ESMO Open, the findings expand the potential for p...

An international group led by researchers from the RIKEN Center for Integrative Medical Sciences (IMS) in Japan have discovered associations between pathogenic variants of the #BRCA genes & 4 types of cancer.

#hereditarycancer #genetics #cancerresearch #medsky

🔬NEW study (RIKEN Center for Integrative Medical Sciences) links: #BRCA1 → #thyroidcancer and #BRCA2 → #bladdercancer, #skincancer, head & neck #cancer
A step toward extending #precisionmedicine beyond common cancers. #BRCA #Oncology #CancerResearch
www.linkedin.com/posts/drmelv...

Jill Martin’s Call to Action: A Deep Dive into the Life-Saving Potential of Genetic Testing "TODAY" contributor, Jill Martin, recently shared an emotional revelation with the world – she was diagnosed with breast cancer.

#GeneticTesting

#CancerScreening for hereditary cancer genes can be lifesaving and is increasingly available. Please read the story of this woman whose family carries a #BRCA gene

www.lifeandstylemag.com/contributors...

Health screenings for BRCA carriers do not stop after preventive surgery. Here's what came up at my 6 month high-risk check up and why it matters.

@oncodaily.bsky.social @oncoalert.bsky.social
#BRCA #Previvor #HereditaryCancer #OncoDaily #OncoAlert

Frontiers | Testing for hereditary cancer genes in men: a missed opportunity for cancer prevention IntroductionGenetic testing for inherited cancer risk syndromes can inform targeted surveillance and intervention, but testing for male patients is inadequat...

Men represented a minority in #genetictesting for #hereditarycancer but had ⬆️ test + rates. These findings underscore the need for ⬆️ integration of routine screening for cancer risk factors in primary care settings to enhance early detection & prevention.

#menshealth #BRCA #medsky #cancerresearch

Surgical Outcomes After Risk-Reducing Mastectomy Among BRCA1 and BRCA2 Carriers This cohort study analyzes cancer risk and surgical complications after risk-reducing mastectomy for BRCA1 and BRCA2 carriers.

In this cohort study of 1208 women with a gPV in #BRCA the risk of developing #breastcancer or early major surgical complications after RRM was very ⬇️. The low occurrence of primary BC precluded meaningful statistical comparisons between different RRM techniques.

#bcsm

@jamanetworkopen.com

No Survival Advantage for Risk-Reducing Mastectomy Over Surveillance in BRCA1/2 Carriers | Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways Study finds risk-reducing mastectomy in BRCA1/2 carriers significantly cuts cancer risk but offers no overall survival benefit over intensive surveillance.

UK Study finds risk-reducing mastectomy in #BRCA carriers significantly cuts #breastcancer risk but offers no overall survival benefit over intensive surveillance. @targetedonc.bsky.social

#hereditarycancer #bcsm #womenshealth #genetics #cancerresearch #medsky

Association between type and location of germline BRCA1/2 pathogenic or likely pathogenic variants with phenotype and prognosis in young patients with breast cancer: results from an international coho... The clinical implications of specific pathogenic and likely pathogenic variant (LP/PV) types and locations in the BRCA1 or BRCA2 tumor-suppressor genes remain to be elucidated.

Association between type and location of germline #BRCA pathogenic or likely pathogenic variants with phenotype and prognosis in young patients with #breastcancer: Results from an international cohort study.

#bcsm #hereditarycancer #womenshealth #genetics #cancerresearch

Menopause, Menarche Impact Breast Cancer Risk in BRCA Carriers In a compelling advance for cancer genetics and epidemiology, a groundbreaking study has been published exploring the interplay between natural reproductive milestones and breast cancer risk among

Natural menopause, menarche and #breastcancer risk in #BRCA pathogenic variant carriers: A Mendelian randomization analysis by UK researchers.

#hereditarycancer #bcsm #medsky #womenshealth #genetics

💊 5 fármacos clave contra el cáncer de mama en China

Terapias ADC e inhibidores PARP están marcando tendencia en HER2+ y BRCA.

🎥 Descubre más en el video

#CáncerDeMama #HER2 #BRCA #Oncología #ADC #PARP #ChinaPharma

🧬 4 inhibidores clave de #PARP en el tratamiento del cáncer de próstata
💊 Terapia dirigida
🎯 Mutaciones #BRCA
🔗 Tratamientos combinados

#CáncerDePróstata #PARPInhibitors #MedicinaDePrecisión #PrecisionMedicine #TerapiaDirigida #TargetedTherapy #HRR #DNARepair #DengYueMedicinasEnHongKong

Understanding <I>BRCA</I> Mutations in Prostate Cancer and New Treatment Advances Most people think of BRCA genes as a women’s health issue, linked to breast and ovarian cancer. But they affect men too, as men are just as likely to have BRCA mutations. And it turns out that alterat...

#BRCA Isn’t Just About #Women

#cancer

mirakind.org/brca-mutatio...

Impact of Germline BRCA Mutation Status on Antitumor Activity of Modified FOLFIRINOX in Patients With Advanced Pancreatic Cancer: An Exploratory Analysis | JCO Precision Oncology PURPOSEGermline BRCA (gBRCA) mutations confer increased sensitivity to platinum-based chemotherapy and have been associated with improved survival across several malignancies. This study investigated ...

Mutación BRCA en la línea germinal se asocia con mejores respuestas radiológicas y biológicas a FOLFIRINOX modificado enel cáncer de páncreas avanzado #brca #APC ascopubs.org/doi/full/10....

Previvorship - Final report Final project report: Social media for carriers of hereditary cancer syndromes

Final project report: Social media for carriers of hereditary cancer syndromes. @stefaniavicari.bsky.social @leverhulme.ac.uk

www.previvorship.org/final-report

#BRCA #lynchsyndrome #socialmedia #research #hereditarycancer

Attending SGO this year? Add "Love, Danielle" when registering! This story needed to be told and I am so grateful it is now being seen by the medical community at one of the most important women's cancer conferences of the year. www.sgo.org/events/annua...

#GynecologicOncology #BRCA

LinkedIn This link will take you to a page that’s not on LinkedIn

Those interested in #Socialmedia in health care, check our this project Previvorship www.previvorship.org) report on Social Media for Carriers of Hereditary Syndromes lnkd.in/eds-kMDm #gyncsm #lynchsyndrome #BRCA #bcsm

A rev in Ther Adv Med Onc highlights the unique challenges of early breast cancer in young BRCA carriers-covering surveillance, risk‑reducing surgery, PARP‑based therapy, fertility considerations, and survivorship needs. 🔗https://buff.ly/6fj4pvT
#BreastCancer #BRCA #Oncology #YoungPatients

30,000 People Tested in NHS Jewish BRCA Programme - The Institute of Cancer Research - OncoDaily 30,000 People Tested in NHS Jewish BRCA Programme - The Institute of Cancer Research / cancer, Clare Turnbull, NHS Jewish BRCA Testing Programme, OncoDaily,

The Institute of Cancer Research - 30,000 People Tested in NHS Jewish BRCA Programme

@england.nhs.uk @icr.ac.uk

oncodaily.com/voices/the-i...

#OncoDaily #Oncology #Cancer #Health #Medicine #BRCA #MedX #MedTwitter

🧬Hoy hace8️⃣0️⃣años nació la #genetista #MaryClaireKing, quien identificó los genes #BRCA 1 y 2 -responsables del #cáncer de #mama- y trabajó en #DerechosHumanos.
Rescatamos su excelente bio en @mujeresconciencia.com:
url.td/QE1dl

Hormonal birth control is safe for most people, but for some, it may slightly increase breast cancer risk. Learn more about the benefits, risks, and considerations for different birth control options here: bit.ly/4gVAzvB

#BreastCancer #CancerPreventionMonth #BreastCancerRisk #BRCA #GeneticTesting

Risk-Reducing Mastectomy, Surveillance Lead to Similar Survival in BRCA Carriers 'Reassuring' data show more breast cancers with surveillance, but no difference in survival

"There is no universal right choice." -- Katharine Schulz-Costello, DO, of @cityofhope.bsky.social, discussing the choice between risk-reducing mastectomy or radiographic surveillance for #BRCA carriers.
www.medpagetoday.com/hematologyon...

Black & BRCA

#BRCA #genetictesting #genechat #hereditarycancer

Risk-Reducing Mastectomy, Surveillance Lead to Similar Survival in BRCA Carriers 'Reassuring' data show more breast cancers with surveillance, but no difference in survival

Risk-Reducing Mastectomy, Surveillance Lead to Similar Survival in #BRCA Carriers.
@medpagetoday.com

#bcsm #hereditarycancer #womenshealth #medsky #genetics

Three weeks post-mastectomy. I feel better, and confidence is following suit. 🫡 #mastectomy #BRCA1 #BRCA #breastcancerawareness #geneticmutation #aestheticflatclosure #healing #surgery #results #post-op #bilateralmastectomy #preventativemastectomy #artist #musician #writer #author #confident

A novel metabolic gene signature induced by Di-(2-ethylhexyl) phthalate and Mono-(2-ethylhexyl) phthalate exposure predicts prognosis in breast cancer: An integrative bioinformatics and experimental s... Di-(2-ethylhexyl) phthalate (DEHP) and its metabolite mono-(2-ethylhexyl) phthalate (MEHP) are endocrine-disrupting chemicals linked to breast cancer …

#health #gerontology #ecology #womenshealth #menopause #endocrinology #exposome #BRCA

The phthalate plasticizer DEHP
and its metabolite MEHP
promote the proliferation and migration of
breast cancer cells.
.
www.sciencedirect.com/science/arti...

We analyzed 17 BRCA1 and BRCA2 variants associated with hereditary breast and ovarian cancer to evaluate their impact on RNA splicing. Eight variants showed aberrant splicing, while nine had no spliceogenic effect, enabling improved variant classification. 🔬 This work contributes to refining the clinical interpretation of BRCA1 and BRCA2 variants and highlights the importance of combining experimental and computational evidence for genetic risk assessment. https://academic.oup.com/clinchem/advance-article/doi/10.1093/clinchem/hvaf177/8416539. https://doi.org/10.1093/clinchem/hvaf177. Epub ahead of print. PMID: 41499258.

✨ We are starting the year with great news! 🎉 Our new paper titled "Splicing predictions, splicing assays and variant classification using ACMG/AMP guidelines: challenges observed with BRCA1 and BRCA2 variants" has been published. 🧬
#Genetics #BRCA #HereditaryCancer #Splicing #ACMG #Research