[BioRxiv] Single cell landscape of sex differences in the progression of multiple sclerosis
https://doi.org/10.1101/2024.06.15.599139
#neurodegeneration #biorxiv #biomarker #Neurodegeneration #excitotoxicity
[BioRxiv] Activity-dependent mitochondrial transport in peri-synaptic glia drives motor function
https://doi.org/10.1101/2021.11.29.470476
#neurodegeneration #biorxiv #Neurodegeneration #excitotoxicity
![Phytocannabinoids CBD and Δ9-THC
In addition to the phytocannabinoid Δ9-THC, it is estimated that the cannabis plant consists of over 400 chemical entities, of which more than 60 of them are phytocannabinoid compounds. Some of these compounds have been identified as acting uniquely on both CB1 and CB2 receptors separately and simultaneously, and/or to inhibit or activate receptor functions. CBD, like Δ9-THC, is a major phytocannabinoid accounting for up to 40% of the plant's extract. CBD was first discovered in 1940 more than 20 years before Δ9-THC.[104,105] Until recently, Δ9-THC dominated cannabis research. All classes of phytocannabinoid compounds found in marijuana and hemp, including Δ9-THC and CBD, are derived from various changes to base molecular structure of cannabigerol-type compounds [Figure 1].[34,49]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cwg2zyfzx2hljvnhavdzeft4/bafkreia57mbt2zz5imp64qvmr5loxs2g3crxwivnt2ijzlhy5s2gpwdfby)
Phytocannabinoids CBD and Δ9-THC In addition to the phytocannabinoid Δ9-THC, it is estimated that the cannabis plant consists of over 400 chemical entities, of which more than 60 of them are phytocannabinoid compounds. Some of these compounds have been identified as acting uniquely on both CB1 and CB2 receptors separately and simultaneously, and/or to inhibit or activate receptor functions. CBD, like Δ9-THC, is a major phytocannabinoid accounting for up to 40% of the plant's extract. CBD was first discovered in 1940 more than 20 years before Δ9-THC.[104,105] Until recently, Δ9-THC dominated cannabis research. All classes of phytocannabinoid compounds found in marijuana and hemp, including Δ9-THC and CBD, are derived from various changes to base molecular structure of cannabigerol-type compounds [Figure 1].[34,49]
#Kulturkampf #Medizin
.. promise in modulating numerous processes associated with #neurodegenerativediseases, #cancer, #epilepsy, and #traumaticbraininjury Table 1]. In addition, the #ECS is known to influence #neuroplasticity, #apoptosis, #excitotoxicity […]
[Original post on mastodon.social]
Screenshot of the title page of the paper including the abstract and some introduction
Have YOU ever wanted to assess NMDAR-dependent excitotoxicity ex vivo? Perhaps you have a disease model and you want to know if excitotoxic cell death is a key player. Well, check out our new methods paper to learn how! 💫
www.sciencedirect.com/science/arti...
#neuroscience #excitotoxicity #NMDAR
We uncover an unexpected synergy between RNA editing & alternative splicing in the CaV1.3 calcium channel. This mechanism fine-tunes neuronal Ca²⁺ entry & may protect against excitotoxicity.
#IonChannels #CalciumChannel #CACNA1D #ExcitoToxicity
Tweet 3 (Discovery)
🌪️No KAT2=↑ #OxidativeStress +⚡ #Excitotoxicity +🛡️↓ protective KYNA! Mice sink into #Despair—but #Anxiety & #Memory stay intact! A razor-sharp #Depression model 🔍💭 #PTSD #Neuroscience #MentalHealth #Kynurenine #TranslationalResearch
Dive in & share!
doi.org/10.31083/FBL...
Tweet 3 (Discovery)
🌪️No KAT2=↑ #OxidativeStress +⚡ #Excitotoxicity +🛡️↓ protective KYNA! Mice sink into #Despair—but #Anxiety & #Memory stay intact! A razor-sharp #Depression model 🔍💭 @istry_media @ImrPress @Landmark_IMR @ChuaCyndi2020 #PTSD #Neuroscience
Dive in & share!
doi.org/10.31083/FBL...
#Medsky🧪#Neurosky #pharmasky #drugdelivery #Ischemicstroke affects millions of people annually with limited treatment options targeting #excitotoxicity, a major cause of cognitive impairment. The PSD-95 inhibitor NA-1 has demonstrated neuroprotective potential,
Findings suggest distinct pathways influence prognosis at different time points
Mid-term outcomes are linked to #excitotoxicity aligning with prior GWAS
Long-term outcomes maigth involve #angiogenesis
Recurrence seems associated with #coagulation
Key point: Optogenetic stimulation of dentate gyrus granule cells leads to strong synaptic activation of mossy cells.
doi.org/10.1111/epi....
#epilepsy #ILAE #channelrhodopsin2 #excitotoxicity #patchclamp #retigabine #temporallobeepilepsy
SciTech Chronicles. . . . . . . . .Feb 20th, 2025
bit.ly/stc022025
#Primary #excitotoxicity #neurodegeneration #neuroinflammation #QPU #topoconductor #Majorana #fermion #CO2 #methanol #tetramethoxyphthalocyanine #cobalt #WEST #fusion #Tokamak #ITER #Algae #bloom #chlorine #UV
