March 2026 GO Release now available March 2026 GO Release (2026-03-25) Now Available We’re pleased to announce that the March 2026 Gene Ontology release is now live! Quick Access Links Current Release: https://current.geneontology.org...

🐰 The Easter bunny delivered early! The March 2026 Gene Ontology release is here with 38,560 GO terms, 8.8M annotations across 5,557 species. Your functional genomics just got a spring upgrade!
🔗 current.geneontology.org
📋 community.alliancegenome.org/t/8648
#GeneOntology #Bioinformatics #Genomics

January 2026 GO Release now available Start 2026 off fresh! The January 2026 GO Release (2026-01-23/) is now available. current.geneontology.org release.geneontology.org Gene Ontology Data Archive 10.5281/zenodo.18422732 38,739 GO te...

🚀January #GeneOntology release is here! Now covering 1.7M bioentities with 9.4M annotations across 5,500+ taxa✨

🔗 Get the data:
📊 current.geneontology.org
📁 doi.org/10.5281/zeno...

Details: community.alliancegenome.org/t/8613 via @alliancegenome.bsky.social

#Bioinformatics #OpenScience

Comprehensive annotation of the enzymes of Drosophila melanogaster Abstract. We have completed a systematic survey of Drosophila melanogaster enzymes, improving the coverage and accuracy of their functional Gene Ontology a

Proud of latest publication on #Drosophila #enzymes at doi.org/10.1093/g3jo..., representing several years of diligent work enhancing fly enzyme annotations and display at @flybase.bsky.social and significant improvements of the #GeneOntology.

Lots of #GeneOntology in this work as well! GO analysis showed enrichment of upregulated genes in pheromone signaling, cell wall biogenesis, cell shape regulation; downregulated genes associated with cell cycle progression, chromatin remodeling, histone gene expression, nucleosome organization

The Gene Ontology knowledgebase in 2026 Abstract. The Gene Ontology (GO) knowledgebase (https://geneontology.org) is a comprehensive resource describing the functions of genes. The GO knowledgeba

As a final nod to 2025, #GeneOntology announces our latest paper in @narjournal.bsky.social! Updates include expanded #Ontology & annotations in #Metabolism, multi-org interactions, #chromatin remodeling, & more.

Also ft. #Functionome v2 and 1500+ GO-CAM pathway models! 🧬🧪

doi.org/10.1093/nar/...

👏 Congratulations 🎉 to PhD student Daiqing Chen for her #PosterAward at @amsocmatbio.bsky.social for "The MatriGO Project: Systematic Curation and Refinement of ECM-related Terms in #GeneOntology" #UIC #MatrixBiology #Science

A review on Gene Ontology evaluations Abstract. The analysis of the large and heterogeneous datasets that characterize modern biology demands systems capable of representing biological knowledg

From @borja-pitarch.bsky.social and colleagues in #OUP 's #DATABASE journal | A review on #GeneOntology evaluations | #Bioinformatics #Genomics #Review #OpenScience #GO 🧬 🖥️ 🧪 🔓🇪🇸
⬇️
academic.oup.com/database/art...

US genomics pioneer Paul Thomas joins SIB as Swiss-Prot co-director Paul Thomas joins Alan Bridge in leading SIB’s largest group, based in Geneva. As a pioneer in computational biology for genomics, principal investigator of a globally important resource on gene...

🧬 US genomics expert Paul Thomas joins SIB as Swiss-Prot co-director, with @alanbridge.bsky.social
🔍 Leader in gene function research; among the world’s most-cited scientists
📊 His arrival strengthens SIB’s role in generating trustworthy, AI-ready biological knowledge #UniProt #GeneOntology
More 👇

Excellent talk by Rund Tawfiq on a systems view of GO annotations, considering not each GO term and each protein separately, but the coverage of consistent functions over a genome. #ismbeccb2025 #GeneOntology
www.biorxiv.org/content/10.1101/2025.07....

@svalver.bsky.social et al. analyzed 15 years of Gene Ontology evolution, finding that GO changes not just incrementally, but also via major, curator-driven restructurings.

🔗 doi.org/10.1093/molbev/msaf148

#evobio #geneontology

Intriguingly,🤔 a number of functional #GeneOntology categories showed divergent regulation 🧬 with #aging at the transcriptomic and epigenomic levels as a function of 🐁 animal #sex, including #phagocytosis, #metabolism and #inflammatory pathways. 5/13

In small study #GeneOntology analysis revealed that both acute & long-term effects of fatigue were associated with abnormal social behavior. The findings reveal 🧠 network reconfiguration trajectories during post-viral fatigue progression that serve as functional biomarkers for tracking NC sequelae.

Next in the Edu-Vid series is #GeneOntology'.
A catalog of genes, their functions and where they are expressed.
youtu.be/cP-GjeOzfvU

With @sciencebagels.bsky.social #SciBagels

There are 220 #BiochemicalPathways in #Yeast, involving 557 different #genes - all this info has now been incorporated into #GeneOntology annotations - check it out!

www.yeastgenome.org/blog/yeast-b...

🧬New article: "getENRICH: a tool for the gene and pathway enrichment analysis of non-model organisms"

Full access here: https://doi.org/10.1093/bioadv/vbaf023 

#GeneOntology #PathwayAnalysis

Go Enrichment Analysis of how melatonin alleviates TNF-α-induced damage in human coronary artery endothelial cells (HCAECs) using RNA-seq

🌟 Project Update🧬
The most overrepresented Gene Ontology terms included

🦠 Defense response to virus (GO:0051607)
🤝 Defense response to symbiont (GO:0140546)
🛡️ Immune response (GO:0006955)
⚡ Response to biotic stimulus (GO:0009607)
💡 Innate immune response (GO:0045087)

#Bioinformatics #GeneOntology

Screenshot of the pathway ORA analysis livestream on https://youtube.com/c/DannyArends

I thought this live-stream would perform a lot better, are people not interested in how pathway ORA works?

youtube.com/live/MJ4A5fmgW…

#Bioinformatics #RStats #Pathways #ORA #GeneOntology #fromScratch

captain america says i understood that reference ALT: captain america says i understood that reference

Ever see a #GeneOntology annotation that doesn't use a PMID as a reference, but instead has GO_REF: and a bunch of numbers?

Find out what a GO_REF is & where to find full descriptions of them in this week's Alliance Forums post: community.alliancegenome.org/t/whats-a-go...

Transitivity in GO: Most annotations go up, but *NOT* all do! Our Gene Ontology overview page goes over how the GO is a loosely hierarchical graph, with GO terms as nodes and the relationships between terms are the edges between nodes. In the GO, ‘child’ terms a...

Most #GeneOntology annotations propagate up the #ontology- but do you know how to identify ones that do NOT?

Read more on the @alliancegenome.bsky.social Forum:
community.alliancegenome.org/t/transitivi...

Happy #DNADay2024! 🧬

Today's @alliancegenome.bsky.social forum post highlights some of the close ties between the Human Genome Project and the #GeneOntology: both Dr. David Botstein and Dr. Paul Thomas.
community.alliancegenome.org/t/happy-dna-...
🧪

Today's paper highlight: new Scientific Reports publication that uses #GeneOntology and could help advance research on liver cancer #CancerResearch
🧪

community.alliancegenome.org/t/go-and-hep...

GO and murine forelimb development In the latest iScience issue, Jacobson et al. examine extracellular matrix (ECM) protein dynamics in the mouse embryo. They found distinct differences when compared to other developing organs, and al...

Paper alert! In the latest issue of iScience, Jacobson et al. investigate extracellular matrix protein dynamics in developing murine forelimbs, with the help of #geneontology!
🧪🌾🔬🦠

community.alliancegenome.org/t/go-and-mur...

Gene Ontology (GO) Terms for NCBI RefSeq Eukaryotic Genomes - NCBI Insights Are you interested in more functional information about protein-coding genes? We’ve expanded NCBI RefSeq’s Eukaryote Genome Annotation Pipeline (EGAP) to include Gene Ontology (GO) terms compute...

Gene Ontology is being added for all NCBI RefSeq Eukaryote genomes (1.7K and growing), called by interProScan + Panther/TreeGrafter 😊 #NCBI #GeneOntology 🧬 🖥️

Great question on #GeneOntology list today from @bmeldal: can @biorxivpreprint or other #preprints be used as evidence in GO annotations (or other #biocuration)? What do you all think? #bioPeerReview #ASAPbio @biocurator

Amos Bairoch @calipho2 introduces Paul Thomas #Noctua collaborative models of biological processes #GeneOntology curation @news4go #bc2basel

Wanna code for the #GeneOntology project? We have a position open, can be based in Berkeley or LA. usc.wd5.myworkdayjobs.com/ExternalUSCCareers/job/L...

Noctua (Beta) Noctua Landing Page Noctua Annotation Review

#Noctua: new #geneontology curation tool goes beyond simple annotation into biological modeling http://goo.gl/Jeinbp

Gene Ontology Resource The Gene Ontology (GO) project is a major bioinformatics ...

Help us improve the GO! How can we do better? Take the #geneontology survey http://tinyurl.com/outyy5f ...and win a prize!

Is DAVID, http://david.abcc.ncifcrf.gov/ down? #geneontology #gsea