A noninvasive device used to monitor early fluid accumulation in the lungs of patients with #HFpEF substantially reduced HF hospitalizations and mortality.
Check out the results from the IMPEDANCE-HFPEF trial presented during #ACC26 ➡️ https://bit.ly/47refXm #CardioSky
#ACC26 CADENCE: Sotatercept, an activin signaling inhibitor, was associated with significant improvements in BP and vascular health in patients with #HFpEF and severe combined post and precapillary pulmonary hypertension (CpcPH).
Find out more: bit.ly/4lVI0FL #CardioSky
🫀 SPIRIT-HF at #ACC26: Spironolactone, an aldosterone blocker, compared with placebo, did not show any significant improvement in terms of HF hospitalizations and cardiovascular death at 24 months in patients with #HFpEF or #HFmrEF.
See the results ➡️ https://bit.ly/4cbiPeW #HeartFailure #CardioSky
JAMA Cardiology article, published March 28, 2026, titled "EMPEROR-Preserved Risk Model and Outcomes in the FINEARTS-HF Trial." Figure 1 shows line graphs of incidence rates of clinical outcomes for heart failure patients, based on EMPEROR-Preserved risk scores.
Biomarker-driven #HFpEF risk stratification using the EMPEROR-Preserved model identified higher absolute benefit from finerenone for patients at greatest baseline risk, while relative treatment effect remained uniform.
#ACC26 @accintouch.bsky.social
ja.ma/4tjaGuN
JAMA Cardiology: Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure. Figure 1 and 2 show cubic splines depicting trajectories in the period preceding sudden death. NYHA class and KCCQ-TSS graphs are displayed.
In #HFmrEF/#HFpEF, sudden death was usually preceded by modest worsening of symptoms, declining quality of life, and rising NT-proBNP, similar to other causes of death, limiting prediction specificity.
#ACC26 @accintouch.bsky.social
ja.ma/41tWm6G
#GSK #35Pharma #pulmonaryarterialhypertension #PAH #heartfailure #FrontierBio #pharmalicensing #LukeMiels #siRNAtherapeutics #FrontierBiotech #HS235 #phase1 #clinicaltrials #heartfailurewithpreservedejectionfraction #HFpEF #bestinclasstherapy #activindirectedtherapy #INDstudies
zurl.co/9nkDQ
Elevated S100A9 in #HFpEF hearts drives oxidative stress and mitochondrial dysfunction; its deficiency restores #SIRT3 signaling, improves diastolic function, and reduces #hypertrophy and #fibrosis, supporting S100A9 as a therapeutic target.
#OpenAccess: doi.org/10.1016/j.ge...
What if HFpEF isn’t just a cardiac disease?
We mined 38M+ PubMed abstracts with ML.
5,124 proteins identified.
Strong overlap with metabolic comorbidities.
Top signals? Liver & adipose tissue — not the heart.
HFpEF may be a multi-organ systemic disorder.
#HFpEF #Cardiology #AI
CVrg will be on the ground in New Orleans covering key sessions at ACC 2026.
Conference Coverage details: cv-rg.com/conferences/
#ACC26 #Cardiology #HeartFailure #ClinicalTrials #HFPEF #oHCM #pulmonaryhypertension #CVrg
🆕 clinician infographic highlights the key challenges in diagnosing and managing #HFpEF. 👇
Stay at the forefront of #HeartFailure management with Transform HF Care initiative. Learn more: https://bit.ly/4rJmiqb
#HFWeek2026 #HeartMonth #CardioSky #MedSky
新たな心不全治療戦略：HFpEF病態進行の解明とリンパ管新生の可能性 #名古屋大学 #HFpEF #リンパ管新生
HFpEFの病態進行とその治療戦略としてのリンパ管新生に関する研究成果を紹介。心機能改善への期待が高まります。
心不全の新たな治療法、リンパ管新生の可能性を発見 #愛知県 #名古屋市 #HFpEF #リンパ管 #治療戦略
心不全の一種HFpEFに対する新しい治療戦略が明らかになりました。リンパ管新生を用いることで病態の改善が期待されます。
A recent publication from the lab. #noncoding #hfpef #aging #thyroid #heart
Heart Failure with Preserved Ejection Fraction (HFpEF): Diagnosis, Treatment & Targets
#HFpEF #HeartFailure #HeartHealth #Cardiology #HeartDisease
Sankalpa Chakraborty, Viswanathan Rajagopalan & co used the ZSF1 #RatModel to investigate early and severe age-related heart failure with preserved ejection fraction and showed novel noncoding and coding markers in early- and/or late-ageing-related hypothyroid #HFpEF.
Read doi.org/10.1242/dmm....
Long‑term #EGCG administration prevents #aging‑related cardiac #DiastolicDysfunction and #exercise decline by alleviating #apoptosis, mitochondrial damage, and restoring #CardiacTroponinI, highlighting EGCG as a preventive strategy for #HFpEF.
#OpenAccess: doi.org/10.1016/j.ge...
Explore the 🔝 Clinical Content of 2025: https://bit.ly/3YdIUCm
✅ Expert Analyses:
⭐ The Extravascular #epICD: A Promising Novel Device
⭐ ULTIMATE-DAPT
➕ More!
✅ Patient Case Quizzes:
⭐ Tachycardia in Pregnancy
⭐ Management of #HFpEF
➕ More!
#CardioSky #MedSky
From SCAD in women to #HFpEF updates and lifestyle tips, read the Top 🔟 #CardiologyMag Articles of 2025. 🔗 https://bit.ly/3YdIUCm
#CardioSky #MedSky
Is Targeting Obesity a Future of CV Medicine? A session from the 2024 #FusterCVS answers the question by exploring the promising effects of GLP1-RA semaglutide in reducing MACE & ↗️ symptoms in obesity-related #HFpEF, & more.
🎥 Watch now on #ACCAnywhere! https://bit.ly/3L2yTVv
ICYMI: @jama.com editors choose research of the year, including GLP-1s for heart failure, genomic screening for newborns, shingles vaccine reducing dementia risk, avoiding surgery in low-risk breast cancer, Hep B vaccine in HIV
#HFpEF #diabetes #GUARDIAN #POINTER #Medsky #research
🔎 Can provocative testing during RHC unmask HFpEF?
PAWP with🦵passive leg raise & 🚴♀️low-workload exercise help narrow the diagnostic gray zone.
🧠 Great for ruling in HFpEF — less reliable for ruling it out!
#Hemodynamics #HFpEF
🔗 https://bit.ly/4oxDZro
What's driving #cmHFpEF?
Understand the critical role of immunometabolic dysregulation, chronic inflammation, oxidative stress, and epigenetic regulation in cardiometabolic heart failure with preserved ejection fraction.
👉 buff.ly/xNXmHno
#HFpEF
So, diagnosis is officially Heart Failure with preserved Ejection Fraction #HFpEF . Heart muscles stiff so #diastolic phase not bringing in enough blood to pump out. Explains my fatigue etc. Starting on drug therapy. Whoopee! 🫀🫀🫀
#JAMAROTY25: Semaglutide and Tirzepatide in Patients with HFpEF
#Semaglutide and #Tirzepatide were both associated with a more than 40% lower risk of heart failure hospitalization or all-cause death in patients with cardiometabolic #HFpEF compared with a placebo proxy.
🔗 ja.ma/48BSc1a
How is your team addressing chronic disease education? Share your strategies! 👇
8/7
#MoreThanAJournal #howwehospitalist #HeartFailure #PatientEducation #HospitalMedicine #GDMT #HFpEF #HFrEF #MedTwitter
New in European Heart Journal – Supplements:
PLR-echo markedly enhances HFpEF diagnosis.
A simple, non-invasive approach with potential to reduce reliance on RHC.
DOI: 10.1093/eurheartj/ehaf784.028
#HFpEF #Echocardiography #Cardiology #HeartFailure #EchoResearch #PLR #EHJS #ESC2025
Visceral fat is the hidden driver linking CKD and HFpEF. This Special Communication reframes adiposity as a pathogenic organ fueling renal and cardiac decline. #HFpEF #CKD
More in the newest issue of #JACC: https://bit.ly/43ioRpq
#CardioSky
🫀 New ACC scientific statement in #JACC: Obesity drives risk for HF, CAD & #stroke, but targeted weight loss can change the game. Semaglutide & tirzepatide show promise in #HFpEF, but challenges remain.
🔗 Read the whole statement here: https://bit.ly/43qdfRg
@accintouch.bsky.social #CardioSky
Current NT-proBNP thresholds miss high-BMI patients at risk. In pooled #HFpEF trials, those w/ severe obesity faced over twice the event rate despite “normal” values. It’s time to personalize BNP cutoffs. ⚖️
Explore more in the new issue of #JACC: https://bit.ly/3Lp3JaX
#CardioSky
ICYMI: Featured in JCF-Intersections inaugural issue:
Post-hoc AFFIRM analysis on association between AAD-based rhythm control and mortality risk in AF + HFpEF, despite improved sinus rhythm.
➡️ Calls for modern trials w/ catheter ablation + GDMT.
🔗: bit.ly/4hqDvAw
#HeartFailure #AFib #HFpEF
