Yes, that’s a scientific discussion happening on snowshoes. ❄️🔬
At our Hematopoiesis / Myeloid Cells meeting in Keystone, CO, researchers took networking outside - part of the retreat-style atmosphere of Keystone Symposia.
#KSHemato26 #KSMyeloid26
Missed the meeting? Catch it on demand.
The joint Keystone Symposia on Hematopoiesis & Myeloid Cells: Functional Heterogeneity with Therapeutic Promise is now available to watch anytime.
🎥 keysym.us/KSHemato26OD
🎥 keysym.us/KSMyeloid26OD
#KSHemato26 #KSMyeloid26 #hematopoiesis #myeloidcells
Wrapping up #KSMyeloid26, enjoyed @tfabre.bsky.social
rigorous + rational approach to classifying and targeting myeloid cells in fibrotic diseases. Look forward eagerly to testing their M.A.C.S approach built on scLAVI @mmschaefer.bsky.social
Final day of #KSMyeloid26 ! Really enjoyed @bainlab.bsky.social talk on RTM repopulation dynamics post-infection. Notable, their work underscores that monocyte replenishment of AM niche (clodr) is sufficient (not Ag from prior infection) for protection. "Monocyte legacy, not training !"
Next, Isabelle Arnold (ETHZ) with a very intriguing talk on neonatal eosinophil biology, showing elegantly how important this population is to microbial homeostasis and immunity later in life. Alongside @arielmunitz.bsky.social , nice representation for these PHILs. #KSMyeloid26
Afternoon session full of great talk at #KSMyeloid26. First, Zimmerman lab (Oklahoma) walks us through the complex and surprisingly non-canonical behavior of renal macs, specifically how Trem2hi macs dictate PKD phenotypes. @keystonesymposia.bsky.social
Molecular and phenotypic blueprint of human #hematopoiesis links proliferation stress to #StemCell #aging. From Emanuele Lettera et al. @dimiccolab.bsky.social: rupress.org/jem/article/...
📘 In Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...
#KSMyeloid26 #KSHemato26
Masterclass from Dan Puleston on metabolic control of aging ! @sinaiimmuno.bsky.social @miriammerad.bsky.social Fundamental shift in how we think of tissular aging– bioavailability of amino acids will dictate niche repopulation and mac fitness, in turn maintaining function. 🤯 #KSMyeloid26
Tet2 deficiency–induced expansion of monocyte-derived #macrophages promotes liver #fibrosis. From Jiuxing Feng, Baitong Wu, Yujiang Geno Shi and colleagues: rupress.org/jem/article/...
📘 In #Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...
#KSMyeloid26 #KSHemato26
Great to finally hear Lai Guan Ng in-person, such a clarifying talk on neutr heterogeneity (see www.cell.com/immunity/abs... and also showed cool data on their feature-proj based framework for classifying TANs. Hope I can someday convince him that BM changes impact TAN fate :D #KSMyeloid26
Day 2 at @KeystoneSymp kicked off by @charlottelscott.bsky.social on liver Mac biology in the context of MASLD and HCC progression. Excellent work showing how little we still understand about Kupffer cells, and how fibrosis is uncoupled from KC activation in the liver. #KSHemato26 #KSMyeloid26
Excellent talk from Jennifer Guerriero @dfcicancerbio.bsky.social
on their clinic-facing work showing importance of TREM2hi lipid-assoc LAMs in breast cancer, the role of these macs in driving PARPi resistance, and their approach to CAR-Macs to target TREM2 in TME and ablate LAMs. #KSMyeloid26
Following up is Stefani Spranger @mitkochinstitute.bsky.social
with a very exciting story on CD103+CD11b+ (dp) DCs playing an important role in CPAC-SIY model of high-grade ovarian cancer. Would be great to see how they localize for local restim (TLS or aggregates?). #KSMyeloid26
Great short talks followed by session on 'Myeloid cells in Tumors'. Started off by @arielmunitz.bsky.social
with very cool provocative data of STAT3 signaling driving tumor eosinophil-CD8 T cell interaction in lung mets. #KSMyeloid26
Standout ST from Silvia Pires from RandyLongman lab @weillcornell.bsky.social showing education of neutrophilic lineages in IBD by GM-CSF from TL1A-activated ILC3, driving pro-tumoral specification (+ link to arthritis via training). So cool to see the EM grammar holding true ! #KSMyeloid26
pDCs amplify tissue-resident memory CD8⁺ T cell responses during viral reinfection. From Elena Hernández-García, Salvador Iborra and colleagues: rupress.org/jem/article/...
📘 In #Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...
#KSMyeloid26 #KSHemato26
Super cool work from @shalinhnaik.bsky.social
on scaling up DC1 immunotherapy (modular differentiation using BATF3) as well as CAR-approach based activation in situ to avoid classical issues with DC manufacturing (GM-DCs and tolerogenic). Gargantuan effort at @petermaccc.bsky.social ! #KSMyeloid26
Thymic myeloid cells are heterogenous and include a novel population of transitional #DendriticCells. From Matouš Vobořil, Kristin Hogquist and colleagues: rupress.org/jem/article/...
📘 In #Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...
#KSMyeloid26 #KSHemato26
Great kick-off to the conference by @florentginhoux.bsky.social
covering diet-dependent regulation of resident tissue macs as well as developmental + functional heterogeneity of tumoral macs ! #KSHemato26 #KSMyeloid26
#Radiotherapy induces YTHDF2 in #DendriticCells impairing cross-presentation and T cell function, from Dapeng Chen, Chuan He, Hua Laura Liang, Ralph Weichselbaum et al: rupress.org/jem/article/...
📘 In #Hematopoiesis & #Myeloid Cells collection: rupress.org/jem/collecti...
#KSMyeloid26 #KSHemato26
Mechanometabolism instructs hematopoietic stem cell specification, from Paulina Horton, Pamela Wenzel and colleagues: rupress.org/jem/article/...
📘 In #Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...
#KSMyeloid26 #KSHemato26
Enroute to Keystone for @keystonesymposia.bsky.social (become a ritual now) on Myeloid cell immunology and Hematopoiesis🩸Excited to meet peers and discuss our latest work on tumor-associated myelopoiesis ! If you’re also attending, come say hi ! 🏔️👨🏾🔬 #KSMyeloid26 #KSHemato26 #Immunology #Newlab
A #circadian checkpoint relocates #neutrophils to minimize injury, from Aroca-Crevillén, Hidalgo @drusqui.bsky.social and colleagues: rupress.org/jem/article/...
📘 In #Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...
#KSMyeloid26 #KSHemato26
Heart of the matter: #Neutrophils, #cancer, and #CardiovascularDisease. Review from Ambreen, McCarthy, Hidalgo, and @adrover.bsky.social: rupress.org/jem/article/...
📘 In #Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...
#KSMyeloid26 #KSHemato26
A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated #macrophages in #lupus #nephritis. From Hoover, Hacohen, Davidson & colleagues: rupress.org/jem/article/...
📘 In #Hematopoiesis & #Myeloid Cells collection: rupress.org/jem/collecti...
#KSMyeloid26 #KSHemato26
XPR1 regulates fetal liver #macrophage development, identity and pyrenocyte clearance. From Sebastian Stifter, Melanie Greter and colleagues: rupress.org/jem/article/...
📘 In #Hematopoiesis and #Myeloid Cells collection: rupress.org/jem/collecti...
#KSMyeloid26 #KSHemato26
Attending @keystonesymposia.bsky.social meeting on Hematopoiesis + Myeloid Cells and interested in discussing your work with a JEM editor? Be sure to get in touch with Gaia Trincucci (@gaiajexpmed.bsky.social) who will be there!
📩 Email Gaia: rupress.org/jem/pages/ed...
#KSMyeloid26 #KSHemato26
🌐 Explore emerging research with field leaders @keystoneSymposia.bsky.social #MyeloidCells : Heterogeneity & Therapeutic Promise, February 23-26 in Keystone🌲 JEM's Deputy Editor Gaia Trincucci @gaiajexpmed.bsky.social is attending! Register 👉 www.keystonesymposia.org/conferences/...
#KSMyeloid26
