This review highlights #lipophagy as a key regulator of lipid balance and #oxidativestress, with dysregulation tied to #obesity, cardiovascular and #NeurodegenerativeDiseases, emphasizing its therapeutic potential in lipid‑related disorders.

#OpenAccess: doi.org/10.1016/j.ge...

This latest review explores the role of #Perilipin 2 (PLIN2) in #LipidDroplet biogenesis, contact sites, dynamics, and #Lipophagy, spotlighting new #therapeutic opportunities targeting #PLIN2 for #LiverDisease intervention. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

This review highlights the role of #Perilipin2 (PLIN2) in the pathogenesis of #liverdisease through #LipidDroplets (LDs) biogenesis, LD contact sites, LD dynamics, and #lipophagy and discusses the opportunities for PLIN2-targeted therapy for liver disease. #medsky
#OpenAccess:
buff.ly/x4u9XE3

Rab GTPases as "eat me" signals for selective #autophagy. Yan Zhao discusses new work from Qiming Sun and colleagues (rupress.org/jcb/article/...), which shows how Rab GTPases serve as cues for cargo receptor recruitment, mediating #mitophagy, #lipophagy, and #xenophagy. rupress.org/jcb/article/...

Rab #GTPases are evolutionarily conserved signals mediating selective #autophagy, say Pengwei Zhao, Rui Tian, Dandan Song, Qi Zhu, Xianming Ding, Wei Zou, Qiming Sun and colleagues @ZJU_China: rupress.org/jcb/article/...

#Trafficking #Biochemistry #Mitophagy #Lipophagy #Xenophagy

Spotlight: Yan Zhao previews work from Qiming Sun and colleagues (rupress.org/jcb/article/...), which shows how Rab #GTPases serve as cues for cargo receptor recruitment, mediating #mitophagy, #lipophagy, and #xenophagy. rupress.org/jcb/article/...

#autophagy

This study from the labs of Wei Zou and Qiming Sun @ZJU_China uncovers Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation. rupress.org/jcb/article/...

#mitophagy #lipophagy #xenophagy

RAB18 confers protection to lipid droplets from lysolipophagy and counters cellular steatosis Lipid droplet (LD) enlargement is the most conspicuous cellular phenotype of steatotic liver diseases such as NAFLD and NASH. The small GTPase RAB18 localizes to lipid droplets yet its effects on LD d...

Something is up with #lysosomes and #lipiddroplets and #lipophagy. This preprint took a year to revise but it’s almost done. I would love to hear what the #autophagy field thinks!

www.biorxiv.org/content/10.1...