👋Our March issue is out!
Cover: #Adipose – #tumor in #immune escape

👉Reviews on: #metabolism #hematopoiesis ; #amnion ; #brain #lipids
🔬 #mitochondria #LipidDroplets #aging #autophagy #mechanobiology #neurodegeneration #ferroptosis #chromatin #metastasis & more!
www.nature.com/ncb/volumes/...

Wei Zou & Qiming Sun labs uncover Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation. rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#GRC

Happy to share our new paper in @febsj.bsky.social! With
@ondrej-kuda.bsky.social & @fedorovalab.bsky.social we show how #LipidDroplets reshape the lipidome of PUFA-exposed cells, but can also shift function within the same cell, revealing a context-dependent role in #ferroptosis. shorturl.at/TyRl1

In @jcb.org, Zhifang Li et al. reveal that the NRZ tethering complex is a critical regulator of virus-induced ER–LD interactions by enhancing ER–LD contacts, thereby facilitating efficient viral infection. rupress.org/jcb/article/...
#Organelles #Virology #lipid #ER_literature #LipidDroplets

Wei Zou & Qiming Sun labs uncover Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation. rupress.org/jcb/article/...

📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti...
#KSAutophagy26

Zhifang Li et al. reveal that the NRZ tethering complex is a critical regulator of virus-induced ER–LD interactions by enhancing ER–LD contacts, thereby facilitating efficient viral infection. rupress.org/jcb/article/...
#Organelles #Virology #Membrane #lipid #ER_literature #LipidDroplets

Missed our early December webinar with James Olzmann? Catch it here: www.lipidmaps.org/resources/ed...
The webinar offered key insights into lipid metabolism and ferroptosis. Attendees learned about the impact of lipid droplets on cellular lipid balance and ferroptosis.
#LipidDroplets #Lipidomics

Lipid droplets (LDs) are key organelles of cellular lipid homeostasis. They exhibit a remarkable dynamic plasticity in molecular composition, number, localization, and appearance. This LD heterogeneity occurs at multiple levels, resulting in the formation of specific subpopulations that differ across intracellular space, between neighboring cells of the same or different types, and between healthy and diseased conditions. The surface of LDs consists of a phospholipid monolayer with associated enzymes as well as structural and regulatory proteins. The LD surface not only represents the critical interface between the neutral lipid core and the surrounding aqueous cellular environment, but is also a fundamental determinant of LD heterogeneity. This is clearly evident by the selective association of specific proteins to different LD subpopulations. Additional factors determining LD heterogeneity include the formation of contact sites with other organelles, the presence of different neutral lipid classes, LD-LD clustering or dispersion, differences in LD size and number, and the interaction of pathogenic agents with specific LD subpopulations.

#LipidDroplets (LDs) are key organelles of cellular lipid homeostasis. They exhibit a remarkable dynamic plasticity in molecular composition, number, localization, and appearance.

DDHD2 possesses both lipase and transacylase capacities that remodel triglyceride acyl chains | PNAS Hereditary spastic paraplegia subtype SPG54 is a genetic neurological disorder caused by mutations in the DDHD2 gene. Excessive lipid droplet accum...

DDHD2, tied to hereditary spastic paraplegia, acts as both a triglyceride lipase and transacylase. While #lipiddroplets don't accumulate in neurons, this raises key questions about fatty acid composition and LD dynamics in these cells. Congrats to Canals & Airola teams!

www.pnas.org/doi/10.1073/...

3) Our collaborator @biancaschrul.bsky.social demonstrated this by selectively activating a UBXD8-population that localizes on the surface of #LipidDroplets. We think this approach has lots of potential to investigate organellar contact sites.

Navigating lipid droplet proteins – part II: molecular mechanisms underlying ER-to-lipid droplet protein partitioning Lipid droplets (LDs) originate from the endoplasmic reticulum (ER) and are unique among cellular organelles, as they consist of a hydrophobic core of neutral lipids that is surrounded by a phospholipi...

Curious how proteins find their way to #LipidDroplets?

Our bipartite review traces their journey from ER insertion to LD partitioning:

👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning

#Organelles
#EndoplasmicReticulum
#ER_Literature

Navigating lipid droplet proteins – part I: ER targeting routes of lipid droplet-destined membrane proteins Lipid droplets (LDs) are cytosolic lipid storage organelles that derive from the endoplasmic reticulum (ER). Their biogenesis and function are essential for maintaining cellular lipid homeostasis and ...

Curious how proteins find their way to #LipidDroplets?

Our bipartite review traces their journey from ER insertion to LD partitioning:

👉 Navigating lipid droplet proteins - part I: ER targeting routes of LD-destined membrane proteins

#EndoplasmicReticulum
#ER_Literature
#Organelles
#Biochemistry

🎉🎖️We congratulate 🌟Francesca Cervellini 🌟 @tigem.bsky.social on winning the FEBS Letters #PosterPrize at the #EMBO Workshop on #LipidDroplets, held in Sant Feliu de Guíxols, Spain! 🎉👏👏👏

#EMBOlipidDroplets

Another great EMBO #LipidDroplets workshop in Sant Feliu de Guixols! Many thanks to Maria Bohnert, Robin Klemm, and Bianca Schrul for the wonderful organization!

2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction - Nature Metabolism CLPP-deficiency-driven mitochondrial dysfunction in brown adipose tissue leads to the accumulation of d-2-hydroxyglutarate, in turn promoting lipid-droplet enlargement by altering gene expression and epigenetically regulating nuclear stiffness.

I hope this cover art captures the paper’s essence and pays tribute to the true molecular painter here: 𝘊𝘭𝘱𝘱 🧑‍🎨
You can read the paper here 🔗 www.nature.com/articles/s42...

#mitochondria #lipiddroplets #lipids #RNAseq #metabolomics #proteomics #multiomics @cecad.bsky.social @unicologne.bsky.social

Lipid droplets: Open questions and conceptual advances around a unique organelle. New review from Mike Henne (@hennelab.bsky.social), Emma Reynolds, and William: rupress.org/jcb/article/...

#Biochemistry #CellMetabolism #LipidDroplets

New review: Henne (@hennelab.bsky.social), Reynolds, and Prinz discuss recent discoveries and enduring mysteries in the lipid droplet field. rupress.org/jcb/article/...

#Biochemistry #CellMetabolism #LipidDroplets

New review @jcb.org: Henne (@hennelab.bsky.social), Reynolds, and Prinz discuss recent discoveries and enduring mysteries in the lipid droplet field. rupress.org/jcb/article/...

#Biochemistry #CellMetabolism #LipidDroplets

🔬 From our August issue (rupress.org/jcb/issue/22...): An immunofluorescence image of a primary mouse hepatocyte treated with VCP/p97 siRNA showing endogenous HSD17β13 (yellow) coating #LipidDroplets labeled with Oil Red O (magenta) and nucleus (cyan). From Sen et al. rupress.org/jcb/article/...

An ethanol-induced loss of the lipid droplet–associated segregase VCP/p97 leads to hepatic #steatosis, say Sandhya Sen, Shaun Weller, Mark McNiven and colleagues @mayoclinic.org: rupress.org/jcb/article/...

#LipidDroplets

New insights into the lipid droplet breakdown in alcohol-associated hepatic #steatosis. Chen Zhang and Wen-Xing Ding @kumedcenter.bsky.social highlight new work from Sen et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...

#CellMetabolism #Disease #LipidDroplets

This review highlights the role of #Perilipin2 (PLIN2) in the pathogenesis of #liverdisease through #LipidDroplets (LDs) biogenesis, LD contact sites, LD dynamics, and #lipophagy and discusses the opportunities for PLIN2-targeted therapy for liver disease. #medsky
#OpenAccess:
buff.ly/x4u9XE3

Phosphatidic acid drives spatiotemporal distribution of Pex30 at ER-LD contact sites, say Morgan House, Amit S. Joshi @joshilaboratory.bsky.social‬ and colleagues @utknoxville.bsky.social‬: rupress.org/jcb/article/...

#Organelles #Biochemistry #ER_literature #LipidDroplets #lipids

Lipid Droplets are active translation depots that respond to infection Lipid droplets (LDs) are increasingly recognized as dynamic organelles with roles extending beyond lipid storage. While the core LD proteome across cells reveals minimal overlap, several proteins with...

www.biorxiv.org/content/10.1...

New manuscript alert from our lab. We show that #lipiddroplets serve as depots for active translation, and that these are regulated as a host response to infection! PhD work of Rakesh Jha from our lab.

This study from the labs of Wei Zou and Qiming Sun @ZJU_China uncovers Rab #GTPases as evolutionarily conserved signals mediating selective #autophagy, targeting damaged #mitochondria, #LipidDroplets, and #pathogens for degradation. rupress.org/jcb/article/...

#mitophagy #lipophagy #xenophagy

Gao, Ungermann et al. identify Any1 as a #lipid scramblase that cycles btwn #Golgi and #endosomes and promotes MVB biogenesis. To do so, Any1 cooperates with the lipid transfer protein Vps13, possibly at a contact site with the ER and #LipidDroplets rupress.org/jcb/article/...

👋Our February issue's out!
Cover: #glioblastoma

👉🏼Review on #mitochondria #ProteinImport
👉🏻Viewpoint on #LipidMetabolism
🔬 #HumanEmbryos #NuclearSpeckles #PhaseSeparation #autophagy #mitosis #pluripotency #hematopoiesis #LipidDroplets & more!
www.nature.com/ncb/volumes/...

Super-exciting research topic for a #PhD: #LipidDroplets

Prof. Dr. Bianca Schrul

New grant approved! Hooray! Looking for a #PhDstudent with strong interest in membrane protein reconstitution, physicochemical membrane properties and FRET-based assays. 👉 Which membrane properties drive protein partitioning to #LipidDroplets?

Please share!

#organelles #PhDposition #ScienceJobs

The December issue is online:

www.embopress.org/toc/14693178...

The cover features work by Stacey Gilk @sdgilk.bsky.social @unmc.bsky.social identifying a novel #bacterial effector protein that mediates ER-LD #membrane contacts to regulate host #lipiddroplets.

-> www.embopress.org/doi/full/10....