Yay! 🎉 Another new lab coming online in 2026! HIGHLY RECOMMEND training with @jfhorner.bsky.social as he advances #proteoform level understanding of #mechanosensitive #adhesion proteins. Be sure to follow him and his upcoming work!

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#LARGE #CONDUCTANCE #MECHANOSENSITIVE #CHANNEL
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#OKLAHOMA #CITY #STADIUM
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#BATTLE OF #THE #JABARA #VALLEY
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An overview of the structural features, activation modes, and signaling mechanism of adhesion G protein-coupled receptors (#aGPCRs), with a discussion into the physiological & pathological role of #Mechanosensitive aGPCRs.

#OpenAccess: doi.org/10.1016/j.ge...

The #mechanosensitive channel #Piezo1 in #BMMSCs suppresses #BoneMarrow #adipogenesis and promotes #BoneFormation by blocking the Ccl2–Lcn2 inflammatory loop, linking #mechanotransduction to #inflammation control and bone strength.

#OpenAccess in #STTT: doi.org/10.1038/s413...

This review summarizes the structural features, activation mechanisms, and signaling of #aGPCRs and discusses the physiological and pathological roles of #Mechanosensitive aGPCRs. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Job alert 3: #postdoc #RF position in #mechanobiology at Griffith University, Australia. 🧪

Are you a future leader in #mechanosensitive pathways in #erythrocytes? Join us! Closes 17th Oct

jobs.smartrecruiters.com//GriffithUni...

#microfluidics #biophysics #physiology #glycomics #academicsky

Job alert: #PhD position in #mechanobiology at Griffith University, Gold Coast, Australia.

Are you passionate about exploring #mechanosensitive pathways in #erythrocytes? See below, closes 22nd Oct.

jobs.smartrecruiters.com//GriffithUni...

#microfluidics #biophysics #physiology #academicsky

An overview of #DistractionHistogenesis (DH), its applications, cellular responses and mechanisms, functions of key #mechanosensitive channels, and the mechanisms translating mechanical signals into histogenic signals during DH. #medsky
#OpenAccess:

About the topical collection 1/3

#Smooth #muscle performs vital functions in a range of organs including lungs & blood vessels. The current research focus on the #mechanosensitive nature of SMcells & advances in technologies, including scRNAseq, has resulted in a renewed interest in SMcell biology.

An overview of #DistractionHistogenesis (DH), its applications, cellular responses and mechanisms, functions of key #mechanosensitive channels, and the mechanisms translating mechanical signals into histogenic signals during DH. #medsky

#OpenAccess:
www.sciencedirect.com/science/arti...

The seeds of this work started back in my postdoc- I spent a lot of time watching cancer cells migrate through tight spaces, and wondered how these spaces would affect adult stem cells, given their functional (and #mechanosensitive) output of differentiation (2/n)

Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis

A review of the #mechanosensitive genes affecting #VascularEndothelialCells, including classical pathways and newly screened genes, and a summary of the latest research on their roles in the pathogenesis of #atherosclerosis. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...

Interesting new paper out showing #chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a #mechanosensitive #checkpoint at the nuclear envelope triggered by altered heterochromatin content and increased nuclear membrane tension.
www.nature.com/articles/s41...

Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin

PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we ...

So many roles for #mechanoreceptors! Here is another one in the gut... feeling #mechanosensitive :)
www.science.org/doi/10.1126/...

#PaulKornerSeminar speaker @Yoshitaka_Nak from @Martinac_Lab - "Our #mechanosensitive channel studies with the #cryoEM facility provided by the Victor Chang #InnovationCentre will elucidate structural aspects of the #glutamate release valve MscCG.

#PaulKornerSeminar speaker @Yoshitaka_Nak from @Martinac_Lab - "Our #mechanosensitive channel studies with the #cryoEM facility provided by the Victor Chang #InnovationCentre will elucidate structural aspects of the #glutamate release valve MscCG.